Max Planck Institute for Biological Intelligence

Publications of the emeritus-department "Neuroimmunology"

Journal Article (381)

2023

Journal Article

Bauer, I. J.; Fang, P.; Lämmle, K. F.; Tyystjärvi, S.; Alterauge, D.; Baumjohann, D.; Yoon, H.; Korn, T.; Wekerle, H.; Kawakami, N.: Visualizing the activation of encephalitogenic T cells in the ileal lamina propria by in vivo two-photon imaging. Proceedings of the National Academy of Sciences of the United States of America 120 (30), e2302697120 (2023)

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Bianchimano, P.; Iwanowski, K.; Smith, E. M.; Cantor, A.; Leone, P.; Bongers, G.; Gonzalez, C. G.; Yoon, H.; Elias, J.; Weiner, H. L. et al.; Clemente, J. C.; Tankou, S. K.: Oral vancomycin treatment suppresses gut trypsin activity and preserves intestinal barrier function during EAE. iScience 26 (11), 108143 (2023)

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Casal Moura, M.; Thompson, G. E.; Nelson, D. R.; Fussner, L. A.; Hummel, A. M.; Jenne, D. E.; Emerling, D.; Fervenza, F. C.; Kallenberg, C. G. M.; Langford, C. A. et al.; McCune, W. J.; Merkel, P. A.; Monach, P. A.; Seo, P.; Spiera, R. F.; St. Clair, E. W.; Ytterberg, S. R.; Stone, J. H.; Robinson, W. H.; Specks, U.: Activation of a latent epitope causing differential binding of anti-neutrophil cytoplasmic antibodies to proteinase 3. Arthritis and Rheumatology 75 (5), pp. 748 - 759 (2023)

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Guarino, C.; Seren, S.; Lemoine, R.; Hummel, A. M.; Margotin, J.-E.; El-Benna, J.; Hoarau, C.; Specks, U.; Jenne, D. E.; Korkmaz, B.: Constitutive and induced forms of membrane-bound proteinase 3 interact with antineutrophil cytoplasmic antibodies and promote immune activation of neutrophils. The Journal of Biological Chemistry 299 (4), 103072 (2023)

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Janakiraman, M.; Leliavski, A.; Varadarajulu, J.; Jenne, D. E.; Krishnamoorthy, G.: An engineered Fc fusion protein that targets antigen-specific T cells and autoantibodies mitigates autoimmune disease. Journal of Neuroinflammation 20, 291 (2023)

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Spella, M.; Ntaliarda, G.; Skiadas, G.; Lamort, A.-S.; Vreka, M.; Marazioti, A.; Lilis, I.; Bouloukou, E.; Giotopoulou, G. A.; Pepe, M. A. A. et al.; Weiss, S. A. I.; Petrera, A.; Hauck, S. M.; Koch, I.; Lindner, M.; Hatz, R. A.; Behr, J.; Arendt, K. A. M.; Giopanou, I.; Brunn, D.; Savai, R.; Jenne, D. E.; de Chateau, M.; Yull, F. E.; Blackwell, T. S.; Stathopoulos, G. T.: Non-oncogene addiction of KRAS-mutant cancers to IL-1beta via versican and mononuclear IKKbeta. Cancers / Molecular Diversity Preservation International (MDPI) 15 (6), 1866 (2023)

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Thomann, A. S.; McQuade, C. A.; Pinjusic, K.; Kolz, A.; Schmitz, R.; Kitamura, D.; Wekerle, H.; Peters, A.: A B cell–driven EAE mouse model reveals the impact of B cell-derived cytokines on CNS autoimmunity. Proceedings of the National Academy of Sciences of the United States of America 120 (47), e2300733120 (2023)

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Yoon, H.; Lee, Y.; Park, H.; Kang, H.-J.; Ji, Y.; Holzapfel, W. H.: Lactobacillus johnsonii BFE6154 ameliorates diet-induced hypercholesterolemia. Probiotics and Antimicrobial Proteins 15 (3), pp. 451 - 459 (2023)

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2022

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Ebert, M.; Jerke, U.; Eulenberg-Gustavus, C.; Kling, L.; Jenne, D. E.; Kirchner, M.; Mertins, P.; Bieringer, M.; Elitok, S.; Eckardt, K.-U. et al.; Schreiber, A.; Salama, A. D.; Kettritz, R.: Protective alpha1-antitrypsin effects in autoimmune vasculitis are compromised by methionine oxidation. The Journal of Clinical Investigation 132 (23), e160089 (2022)

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Kessler, N.; Viehmann, S. F.; Krollmann, C.; Mai, K.; Kirschner, K. M.; Luksch, H.; Kotagiri, P.; Bohner, A. M. C.; Huugen, D.; de Oliveira Mann, C. C. et al.; Otten, S.; Weiss, S. A. I.; Zillinger, T.; Dobrikova, K.; Jenne, D. E.; Behrendt, R.; Ablasser, A.; Bartok, E.; Hartmann, G.; Hopfner, K.-P.; Lyons, P. A.; Boor, P.; Rosen-Wolff, A.; Teichmann, L. L.; Heeringa, P.; Kurts, C.; Garbi, N.: Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing. The Journal of experimental medicine 219 (10), e20220759 (2022)

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Yoon, H.; Lee, Y.; Kang, H. J.; Ju, J.; Ji, Y.; Park, H.; Park, H.; Lee, H.; Holzapfel, W. H.: Two putative probiotic strains improve diet-induced hypercholesterolemia through modulating intestinal cholesterol uptake and hepatic cholesterol efflux. Journal of Applied Microbiology 132 (1), pp. 562 - 570 (2022)

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2021

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Morrone, C.; Smirnova, N. F.; Jeridi, A.; Kneidinger, N.; Hollauer, C.; Schupp, J. C.; Kaminski, N.; Jenne, D. E.; Eickelberg, O.; Yildirim, A. O.: Cathepsin B promotes collagen biosynthesis, which drives bronchiolitis obliterans syndrome. European Respiratory Journal 57 (5), 2001416 (2021)

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Schoeps, B.; Eckfeld, C.; Prokopchuk, O.; Boettcher, J.; Haeussler, D.; Steiger, K.; Demir, I. E.; Knolle, P.; Soehnlein, O.; Jenne, D. E. et al.; Hermann, C. D.; Krueger, A.: TIMP1 triggers neutrophil extracellular trap formation in pancreatic cancer. Cancer Research 81 (13), pp. 3568 - 3579 (2021)

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Seren, S.; Derian, L.; Keles, I.; Guillon, A.; Lesner, A.; Gonzalez, L.; Baranek, T.; Si-Tahar, M.; Marchand-Adam, S.; Jenne, D. E. et al.; Paget, C.; Jouan, Y.; Korkmaz, B.: Proteinase release from activated neutrophils in mechanically ventilated patients with non-COVID-19 and COVID-19 pneumonia. European Respiratory Journal 57 (4), 2003755 (2021)

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2020

Journal Article

Goedel, C.; Kunkel, B.; Kashani, A.; Lassmann, H.; Arumugam, M.; Krishnamoorthy, G.: Perturbation of gut microbiota decreases susceptibility but does not modulate ongoing autoimmune neurological disease. Journal of Neuroinflammation 17 (1), 79 (2020)

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publisher-version

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Korkmaz, B.; Lesner, A.; Marchand-Adam, S.; Moss, C.; Jenne, D. E.: Lung protection by cathepsin C inhibition: A new hope for COVID-19 and ARDS? Journal of Medicinal Chemistry 63 (22), pp. 13258 - 13265 (2020)

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2019

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Cohen, I. R.; Wekerle, H.: Avraham Ben-Nun - Pioneer, fighter, friend. European Journal of Immunology 49 (4), pp. 521 - 522 (2019)

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Enzmann, G.; Adelfio, R.; Godel, A.; Jahromi, N. H.; Tietz, S.; Burgener, S. S.; Deutsch, U.; Wekerle, H.; Benarafa, C.; Engelhardt, B.: The genetic background of mice influences the effects of cigarette smoke on onset and severity of experimental autoimmune encephalomyelitis. International Journal of Molecular Sciences 20 (6), 1433 (2019)

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Mues, M.; Krishnamoorthy, G.: BReDi mouse: A novel transgenic mouse strain to track and deplete Bcells. European Journal of Immunology 49 (3), pp. 500 - 503 (2019)

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Peters, A.; Wekerle, H.: Autoimmune diabetes mellitus and the leaky gut. Proceedings of the National Academy of Sciences of the United States of America 116 (30), pp. 14788 - 14790 (2019)

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Schmidt, F.; Dahlke, K.; Batra, A.; Keye, J.; Wu, H.; Friedrich, M.; Glauben, R.; Ring, C.; Loh, G.; Schaubeck, M. et al.; Hackl, H.; Trajanoski, Z.; Schumann, M.; Kuehl, A. A.; Blaut, M.; Siegmund, B.: Microbial colonization in adulthood shapes the intestinal macrophage compartment. Journal of Crohn's and Colitis 13 (9), pp. 1173 - 1185 (2019)

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Wekerle, H.: Secondary progressive multiple sclerosis and the gut-brain axis. Brain 142, pp. 838 - 840 (2019)

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2018

Journal Article

Berer, K.; Martinez, I.; Walker, A.; Kunkel, B.; Schmitt-Kopplin, P.; Walter, J.; Krishnamoorthy, G.: Dietary non-fermentable fiber prevents autoimmune neurological disease by changing gut metabolic and immune status. Scientific Reports 8, 10431 (2018)

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publisher-version

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Guarino, C.; Gruba, N.; Grzywa, R.; Dyguda-Kazimierowicz, E.; Hamon, Y.; Legowska, M.; Skorenski, M.; Dallet-Choisy, S.; Marchand-Adam, S.; Kellenberger, C. et al.; Jenne, D. E.; Sienczyk, M.; Lesner, A.; Gauthier, F.; Korkmaz, B.: Exploiting the S4-S5 specificity of human neutrophil proteinase 3 to improve the potency of deptidyl Di(chlorophenyl)-phosphonate ester inhibitors: A kinetic and molecular modeling analysis. Journal of Medicinal Chemistry 61 (5), pp. 1858 - 1870 (2018)

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Seren, S.; Abouzaid, M. R.; Eulenberg-Gustavus, C.; Hirschfeld, J.; Soliman, H. N.; Jerke, U.; N'Guessan, K.; Dallet-Choisy, S.; Lesner, A.; Lauritzen, C. et al.; Schacher, B.; Eickholz, P.; Nagy, N.; Szell, M.; Croix, C.; Viaud-Massuard, M.-C.; Aldosari, A. A. F.; Ragunatha, S.; Mostafa, M. I.; Giampieri, F.; Battino, M.; Cornillier, H.; Lorette, G.; Stephan, J.-L.; Goizet, C.; Pedersen, J.; Gauthier, F.; Jenne, D. E.; Marchand-Adam, S.; Chapple, I. L.; Kettritz, R.; Korkmaz, B.: Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis. The Journal of Biological Chemistry 293 (32), pp. 12415 - 12428 (2018)

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Spadaro, M.; Winklmeier, S.; Beltran, E.; Macrini, C.; Hoeftberger, R.; Schuh, E.; Thaler, F. S.; Gerdes, L. A.; Laurent, S.; Gerhards, R. et al.; Braendle, S.; Dornmair, K.; Breithaupt, C.; Krumbholz, M.; Moser, M.; Krishnamoorthy, G.; Kamp, F.; Jenne, D. E.; Hohlfeld, R.; Kuempfel, T.; Lassmann, H.; Kawakami, N.; Meinl, E.: Pathogenicity of human antibodies against myelin oligodendrocyte glycoprotein. Annals of Neurology 84 (2), pp. 315 - 328 (2018)

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Wekerle, H.: Gut molecules control brain inflammation. Nature 557 (7707), pp. 642 - 643 (2018)

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Yoon, H.; Schaubeck, M.; Lagkouvardos, I.; Blesl, A.; Heinzlmeir, S.; Hahne, H.; Clavel, T.; Panda, S.; Ludwig, C.; Kuster, B. et al.; Manichanh, C.; Kump, P.; Haller, D.; Hoermannsperger, G.: Increased pancreatic protease activity in response to antibiotics impairs gut barrier and triggers colitis. Cellular and Molecular Gastroenterology and Hepatology 6 (3), pp. 370 - 388.e3 (2018)

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Zhang, B.; Watt, J. M.; Cordiglieri, C.; Dammermann, W.; Mahon, M. F.; Flügel, A.; Guse, A. H.; Potter, B. V. L.: Small molecule antagonists of NAADP-induced Ca2+ release in T-lymphocytes suggest potential therapeutic agents for autoimmune disease. Scientific Reports 8, 16775 (2018)

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2017

Journal Article

Berer, K.; Gerdes, L. A.; Cekanaviciute, E.; Jia, X.; Xiao, L.; Xia, Z.; Liu, C.; Klotz, L.; Stauffer, U.; Baranzini, S. E. et al.; Kuempfel, T.; Hohlfeld, R.; Krishnamoorthy, G.; Wekerle, H.: Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice. Proceedings of the National Academy of Sciences of the United States of America 114 (40), pp. 10719 - 10724 (2017)

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supplementary-material

Journal Article

Jahromi, N. H.; Tardent, H.; Enzmann, G.; Deutsch, U.; Kawakami, N.; Bittner, S.; Vestweber, D.; Zipp, F.; Stein, J. V.; Engelhardt, B.: A novel cervical spinal cord window preparation allows for two-photon imaging of t-cell interactions with the cervical spinal cord microvasculature during experimental autoimmune encephalomyelitis. Frontiers in immunology 8, 406 (2017)

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Kyratsous, N. I.; Bauer, I. J.; Zhang, G.; Pesic, M.; Bartholomäus, I.; Mues, M.; Fang, P.; Woerner, M.; Everts, S.; Ellwart, J. W. et al.; Watt, J. M.; Potter, B. V. L.; Hohlfeld, R.; Wekerle, H.; Kawakami, N.: Visualizing context-dependent calcium signaling in encephalitogenic T cells in vivo by two-photon microscopy. Proceedings of the National Academy of Sciences of the United States of America 114 (31), pp. E6381 - E6389 (2017)

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Smets, M.; Link, S.; Wolf, P.; Schneider, K.; Solis, V.; Ryan, J.; Meilinger, D.; Qin, W.; Leonhardt, H.: DNMT1 mutations found in HSANIE patients affect interaction with UHRF1 and neuronal differentiation. Human Molecular Genetics 26 (8), pp. 1522 - 1534 (2017)

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Wekerle, H.: Brain Autoimmunity and Intestinal Microbiota: 100 Trillion Game Changers. Trends in Immunology 38 (7), pp. 483 - 497 (2017)

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Wekerle, H.: B cells in multiple sclerosis. Autoimmunity 50 (1), pp. 57 - 60 (2017)

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Wekerle, H.: Nature, nurture, and microbes: The development of multiple sclerosis. Acta Neurologica Scandinavica 136 (Suppl. 201), pp. 22 - 25 (2017)

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2016

Journal Article

Braendle, S. M.; Obermeier, B.; Senel, M.; Bruder, J.; Mentele, R.; Khademi, M.; Olsson, T.; Tumani, H.; Kristoferitsch, W.; Lottspeich, F. et al.; Wekerle, H.; Hohlfeld, R.; Dornmair, K.: Distinct oligoclonal band antibodies in multiple sclerosis recognize ubiquitous self-proteins. Proceedings of the National Academy of Sciences of the United States of America 113 (28), pp. 7864 - 7869 (2016)

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Dau, T.; Edeleva, E. V.; Seidel, S. A. I.; Stockley, R. A.; Braun, D.; Jenne, D. E.: Quantitative analysis of protease recognition by inhibitors in plasma using microscale thermophoresis. Scientific Reports 6, 35413 (2016)

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supplementary-material

Journal Article

Hohlfeld, R.; Dornmair, K.; Meinl, E.; Wekerle, H.: The search for the target antigens of multiple sclerosis, part 1: Autoreactive CD4+T lymphocytes as pathogenic effectors and therapeutic targets. Lancet Neurology 15 (2), pp. 198 - 209 (2016)

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Hohlfeld, R.; Dornmair, K.; Meinl, E.; Wekerle, H.: The search for the target antigens of multiple sclerosis, part 2: CD8+T cells, B cells, and antibodies in the focus of reverse-translational research. Lancet Neurology 15 (3), pp. 317 - 331 (2016)

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Kawakami, N.: In vivo imaging in autoimmune diseases in the central nervous system. Allergology International 65 (3), pp. 235 - 242 (2016)

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Korkmaz, B.; Lesner, A.; Guarino, C.; Wysocka, M.; Kellenberger, C.; Watier, H.; Specks, U.; Gauthier, F.; Jenne, D. E.: Inhibitors and antibody fragments as potential anti-inflammatory therapeutics targeting neutrophil proteinase 3 in human disease. Pharmacological Reviews 68 (3), pp. 603 - 630 (2016)

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Mitsdoerffer, M.; Peters, A.: Tertiary lymphoid organs in central nervous system autoimmunity. Frontiers in immunology 7, 451 (2016)

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Wekerle, H.: The gut-brain connection: Triggering of brain autoimmune disease by commensal gut bacteria. Rheumatology 55, pp. 68 - 75 (2016)

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2015

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Azghandi, S.; Prell, C.; van der Laan, S. W.; Schneider, M.; Malik, R.; Berer, K.; Gerdes, N.; Pasterkamp, G.; Weber, C.; Haffner, C. et al.; Dichgans, M.: Deficiency of the stroke relevant HDAC9 gene attenuates atherosclerosis in accord with allele-specific effects at 7p21.1. Stroke 46 (1), pp. 197 - 202 (2015)

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Held, K.; Bhonsle-Deeng, L.; Siewert, K.; Sato, W.; Beltran, E.; Schmidt, S.; Ruhl, G.; Ng, J. K. M.; Engerer, P.; Moser, M. et al.; Klinkert, W. E. F.; Babbe, H.; Misgeld, T.; Wekerle, H.; Laplaud, D.-A.; Hohlfeld, R.; Dornmair, K.: αβ T-cell receptors from multiple sclerosis brain lesions show MAIT cell-related features. Neurology Neuroimmunology & Neuroinflammation 2 (4), e107 (2015)

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Hoffmann, F. S.; Kuhn, P.-H.; Laurent, S. A.; Hauck, S. M.; Berer, K.; Wendlinger, S. A.; Krumbholz, M.; Khademi, M.; Olsson, T.; Dreyling, M. et al.; Pfister, H.-W.; Alexander, T.; Hiepe, F.; Kuempfel, T.; Crawford, H. C.; Wekerle, H.; Hohlfeld, R.; Lichtenthaler, S. F.; Meinl, E.: The immunoregulator soluble TACI is released by ADAM10 and reflects B cell activation in autoimmunity. Journal of Immunology 194 (2), pp. 542 - 552 (2015)

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Hohlfeld, R.; Wekerle, H.: Multiple sclerosis and microbiota. From genome to metagenome? Nervenarzt 86 (8), pp. 925 - 933 (2015)

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Laurent, S. A.; Hoffmann, F. S.; Kuhn, P.-H.; Cheng, Q.; Chu, Y.; Schmidt-Supprian, M.; Hauck, S. M.; Schuh, E.; Krumbholz, M.; Rübsamen, H. et al.; Wanngren, J.; Khademi, M.; Olsson, T.; Alexander, T.; Hiepe, F.; Pfister, H.-W.; Weber, F.; Jenne, D. E.; Wekerle, H.; Hohlfeld, R.; Lichtenthaler, S. F.; Meinl, E.: γ-secretase directly sheds the survival receptor BCMA from plasma cells. Nature Communications 6, 7333 (2015)

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Nicol, B.; Salou, M.; Laplaud, D.-A.; Wekerle, H.: The autoimmune concept of multiple sclerosis. Presse médicale & Quarterly medical review. Special Issue: Multiple sclerosis 44 (4, Part 2), pp. e103 - e112 (2015)

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