Publications

2015

Journal Article

Rumble, J. M.; Huber, A. K.; Krishnamoorthy, G.; Srinivasan, A.; Giles, D. A.; Zhang, X.; Wang, L.; Segal, B. M.: Neutrophil-related factors as biomarkers in EAE and MS. Journal of Experimental Medicine 212 (1), pp. 23 - 35 (2015)

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Wekerle, H.: Vaccination and narcolepsy: Immune link found? Science translational medicine: Integrating medicine and science 7 (294), 294fs27 (2015)

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Wekerle, H.: Nature plus Nurture: The triggering of multiple sclerosis. Swiss Medical Weekly 145, w14189 (2015)

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2014

Journal Article

Ben-Nun, A.; Kaushansky, N.; Kawakami, N.; Krishnamoorthy, G.; Berer, K.; Liblau, R.; Hohlfeld, R.; Wekerle, H.: From classic to spontaneous and humanized models of multiple sclerosis: Impact on understanding pathogenesis and drug development. Journal of Autoimmunity 54, pp. 33 - 50 (2014)

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Berer, K.; Boziki, M.; Krishnamoorthy, G.: Selective accumulation of pro-inflammatory T cells in the intestine contributes to the resistance to autoimmune demyelinating disease. PLoS One 9 (2), e87876 (2014)

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Berer, K.; Krishnamoorthy, G.: Microbial view of central nervous system autoimmunity. FEBS LETTERS 588 (22), pp. 4207 - 4213 (2014)

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Eberle, M.; Ebel, P.; Wegner, M.-S.; Maennich, J.; Tafferner, N.; Ferreiros, N.; Birod, K.; Schreiber, Y.; Krishnamoorthy, G.; Willecke, K. et al.; Geisslinger, G.; Groesch, S.; Schiffmann, S.: Regulation of ceramide synthase 6 in a spontaneous experimental autoimmune encephalomyelitis model is sex dependent. Biochemical Pharmacology 92 (2), pp. 326 - 335 (2014)

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Koutrolos, M.; Berer, K.; Kawakami, N.; Wekerle, H.; Krishnamoorthy, G.: Treg cells mediate recovery from EAE by controlling effector T cell proliferation and motility in the CNS. Acta Neuropathologica Communications 2, 163 (2014)

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Mohan, H.; Friese, A.; Albrecht, S.; Krumbholz, M.; Elliott, C. L.; Arthur, A.; Menon, R.; Farina, C.; Junker, A.; Stadelmann, C. et al.; Barnett, S. C.; Huitinga, I.; Wekerle, H.; Hohlfeld, R.; Lassmann, H.; Kuhlmann, T.; Linington, C.; Meinl, E.: Transcript profiling of different types of multiple sclerosis lesions yields FGF1 as a promoter of remyelination. Acta Neuropathologica Communications 2, 168 (2014)

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Nischwitz, S.; Faber, H.; Saemann, P. G.; Domingues, H. S.; Krishnamoorthy, G.; Knop, M.; Mueller-Sarnowski, F.; Yassouridis, A.; Weber, F.: Interferon-1a reduces increased interleukin-16 levels in multiple sclerosis patients. Acta Neurologica Scandinavica 130 (1), pp. 46 - 52 (2014)

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Thestrup, T.; Litzlbauer, J.; Bartholomäus, I.; Mues, M.; Russo, L.; Dana, H.; Kovalchuk, Y.; Liang, Y.; Kalamakis, G.; Laukat, Y. et al.; Becker, S.; Witte, G.; Geiger, A.; Allen, T.; Rome, L. C.; Chen, T.-W.; Kim, D. S.; Garaschuk, O.; Griesinger, C.; Griesbeck, O.: Optimized ratiometric calcium sensors for functional in vivo imaging of neurons and T lymphocytes. Nature Methods 11 (2), pp. 175 - 182 (2014)

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2013

Journal Article

Hedberg, C.; Melberg, A.; Kuhl, A.; Jenne, D. E.; Oldfors, A.: Functional characterization of desmin mutant p.P419S Reply [Letter]. European journal of human genetics 21 (6), p. 590 - 590 (2013)

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Kawakami, N.; Bartholomäus, I.; Pesic, M.; Kyratsous, N. I.: Intravital Imaging of Autoreactive T Cells in Living Animals. Methods in Cell Biology 113, pp. 149 - 168 (2013)

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Mayer, M. C.; Breithaupt, C.; Reindl, M.; Schanda, K.; Rostasy, K.; Berger, T.; Dale, R. C.; Brilot, F.; Olsson, T.; Jenne, D. E. et al.; Proebstel, A.-K.; Dornmair, K.; Wekerle, H.; Hohlfeld, R.; Banwell, B.; Bar-Or, A.; Meinl, E.: Distinction and temporal stability of conformational epitopes on myelin oligodendrocyte glycoprotein recognized by patients with different inflammatory central nervous system diseases. Journal of Immunology 191 (7), pp. 3594 - 3604 (2013)

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Molnarfi, N.; Schulze-Topphoff, U.; Weber, M. S.; Patarroyo, J. C.; Prod'homme, T.; Varrin-Doyer, M.; Shetty, A.; Linington, C.; Slavin, A. J.; Hidalgo, J. et al.; Jenne, D. E.; Wekerle, H.; Sobel, R. A.; Bernard, C. C. A.; Shlomchik, M. J.; Zamvil, S. S.: MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies. Journal of Experimental Medicine 210 (13), pp. 2921 - 2937 (2013)

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Mues, M.; Bartholomäus, I.; Thestrup, T.; Griesbeck, O.; Wekerle, H.; Kawakami, N.; Krishnamoorthy, G.: Real-time in vivo analysis of T cell activation in the central nervous system using a genetically encoded calcium indicator. Nature Medicine 19 (6), pp. 778 - 783 (2013)

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Neumann, H.; Wekerle, H.: Brain microglia: Watchdogs with pedigree. Nature Neuroscience 16 (3), pp. 253 - 255 (2013)

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Pesic, M.; Bartholomäus, I.; Kyratsous, N. I.; Heissmeyer, V.; Wekerle, H.; Kawakami, N.: 2-photon imaging of phagocyte-mediated T cell activation in the CNS. The Journal of Clinical Investigation 123 (3), pp. 1192 - 1201 (2013)

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Pesic, M.; Kawakami, N.; Bartholomäus, I.; Kyratsous, N. I.: Imaging of immune cell behavior and function in multiple sclerosis and experimental autoimmune encephalomyelitis. Clinical and Experimental Neuroimmunology 4 (Suppl. 1), pp. 27 - 35 (2013)

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Pohl, M.; Kawakami, N.; Kitic, M.; Bauer, J.; Martins, R.; Fischer, M.-T.; Machado-Santos, J.; Mader, S.; Ellwart, J. W.; Misu, T. et al.; Fujihara, K.; Wekerle, H.; Reindl, M.; Lassmann, H.; Bradl, M.: T cell-activation in neuromyelitis optica lesions plays a role in their formation. Acta Neuropathologica Communications 1, 85 (2013)

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Wekerle, H.: Tissue Hypoxia in Autoimmune Brain Disease: A Columbian Discovery? ANNALS OF NEUROLOGY 74 (6), pp. 765 - 767 (2013)

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Wekerle, H.; Berer, K.; Krishnamoorthy, G.: Remote control - triggering of brain autoimmune disease in the gut. CURRENT OPINION IN IMMUNOLOGY 25 (6), pp. 683 - 689 (2013)

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Wekerle, H.; Meinl, E.: Multiple sclerosis: An old drug plays a new trick. Nature 502 (7471), pp. 314 - 315 (2013)

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2012

Journal Article

Berer, K.; Krishnamoorthy, G.: Commensal gut flora and brain autoimmunity: A love or hate affair? Acta Neuropathologica (Berl) 123 (5), pp. 639 - 651 (2012)

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Bruder, J.; Siewert, K.; Obermeier, B.; Malotka, J.; Scheinert, P.; Kellermann, J.; Ueda, T.; Hohlfeld, R.; Dornmair, K.: Target specificity of an autoreactive pathogenic human gamma delta-T cell receptor in myositis. The Journal of Biological Chemistry 287 (25), pp. 20986 - 20995 (2012)

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Colombo, E.; Cordiglieri, C.; Melli, G.; Newcombe, J.; Krumbholz, M.; Parada, L. F.; Medico, E.; Hohlfeld, R.; Meinl, E.; Farina, C.: Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration. Journal of Experimental Medicine 209 (3), pp. 521 - 535 (2012)

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Derfuss, T.; Meinl, E.: Identifying autoantigens in demyelinating diseases: Valuable clues to diagnosis and treatment? Current Opinion in Neurology 25 (3), pp. 231 - 238 (2012)

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Direnberger, S.; Mues, M.; Micale, V.; Wotjak, C. T.; Dietzel, S.; Schubert, M.; Scharr, A.; Hassan, S.; Wahl-Schott, C.; Biel, M. et al.; Krishnamoorthy, G.; Griesbeck, O.: Biocompatibility of a genetically encoded calcium indicator in a transgenic mouse model. Nature Communications 3, 1031 (2012)

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Eisele, S.; Krumbholz, M.; Fischer, M.-T.; Mohan, H.; Junker, A.; Arzberger, T.; Hohlfeld, R.; Bradl, M.; Lassmann, H.; Meinl, E.: Prospects of transcript profiling for mRNAs and microRNAs using formalin fixed and paraffin embedded dissected autoptic multiple sclerosis lesions. Brain Pathology 22, pp. 607 - 618 (2012)

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Eisele, S.; Krumbholz, M.; Fischer, M.-T.; Mohan, H.; Junker, A.; Arzberger, T.; Hohlfeld, R.; Bradl, M.; Lassmann, H.; Meinl, E.: Prospects of transcript profiling for mRNAs and microRNAs using formalin-fixed and paraffin-embedded dissected autoptic multiple sclerosis lesions. Brain Pathology 22 (5), pp. 607 - 618 (2012)

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Elliott, C.; Lindner, M.; Arthur, A.; Brennan, K.; Jarius, S.; Hussey, J.; Chan, A.; Stroet, A.; Olsson, T.; Willison, H. et al.; Barnett, S. C.; Meinl, E.; Linington, C.: Functional identification of pathogenic autoantibody responses in patients with multiple sclerosis. Brain 135, pp. 1819 - 1833 (2012)

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Hedberg, C.; Melberg, A.; Kuhl, A.; Jenne, D. E.; Oldfors, A.: Autosomal dominant myofibrillar myopathy with arrhythmogenic right ventricular cardiomyopathy 7 is caused by a DES mutation. European journal of human genetics 20 (9), pp. 984 - 985 (2012)

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Held, K.; Eiglmeier, I.; Himmelein, S.; Sinicina, I.; Brandt, T.; Theil, D.; Dornmair, K.; Derfuss, T.: Clonal expansions of CD8(+) T cells in latently HSV-1-infected human trigeminal ganglia. Journal of NeuroVirology 18 (1), pp. 62 - 68 (2012)

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Hohlfeld, R.: Ion channels boost axonal injury in multiple sclerosis. Nature Medicine 18 (12), pp. 1743 - 1745 (2012)

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Hohlfeld, R.; Wekerle, H.: β-Amyloid: Enemy or Remedy? Science translational medicine: Integrating medicine and science 4 (145), 145fs24 (2012)

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Journal Article

Kawakami, N.; Bartholomäus, I.; Pesic, M.; Mues, M.: An autoimmunity odyssey: How autoreactive T cells infiltrate into the CNS. Immunological Reviews 248 (Sp. Iss.), pp. 140 - 155 (2012)

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Kim, S.-M.; Bhonsle, L.; Besgen, P.; Nickel, J.; Backes, A.; Held, K.; Vollmer, S.; Dornmair, K.; Prinz, J. C.: Analysis of the paired TCR α- and β-chains of single human T cells. PLoS One 7 (5), e37338 (2012)

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Krumbholz, M.; Derfuss, T.; Hohlfeld, R.; Meinl, E.: B cells and antibodies in multiple sclerosis pathogenesis and therapy. Nature Reviews Neurology 8 (11), pp. 613 - 623 (2012)

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Lippok, S.; Seidel, S. A. I.; Duhr, S.; Uhland, K.; Holthoff, H.-P.; Jenne, D. E.; Braun, D.: Direct detection of antibody concentration and affinity in human serum using microscale thermophoresis. Analytical Chemistry 84 (8), pp. 3523 - 3530 (2012)

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Mankan, A. K.; Dau, T.; Jenne, D. E.; Hornung, V.: The NLRP3/ASC/Caspase-1 axis regulates IL-1 ss processing in neutrophils. European Journal of Immunology 42 (3), pp. 710 - 715 (2012)

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Mayer, M. C.; Hohlfeld, R.; Meinl, E.: Viability of autoantibody-targets: How to tackle pathogenetic heterogeneity as an obstacle for treatment of multiple sclerosis. JOURNAL OF THE NEUROLOGICAL SCIENCES 319 (1-2), pp. 2 - 7 (2012)

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Mayer, M. C.; Meinl, E.: Glycoproteins as targets of autoantibodies in CNS inflammation: MOG and more. Therapeutic Advances in Neurological Disorders 5 (3), pp. 147 - 159 (2012)

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Meinl, E.; Meister, G.: MicroRNAs in the CSF Macro-advance in MS? Neurology 79 (22), pp. 2162 - 2163 (2012)

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Ng, J. K. M.; Malotka, J.; Kawakami, N.; Derfuss, T.; Khademi, M.; Olsson, T.; Linington, C.; Odaka, M.; Tackenberg, B.; Pruess, H. et al.; Schwab, J. M.; Harms, L.; Harms, H.; Sommer, C.; Rasband, M. N.; Eshed-Eisenbach, Y.; Peles, E.; Hohlfeld, R.; Yuki, N.; Dornmair, K.; Meinl, E.: Neurofascin as a target for autoantibodies in peripheral neuropathies. Neurology 79 (23), pp. 2241 - 2248 (2012)

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Odoardi, F.; Sie, C.; Streyl, K.; Ulaganathan, V. K.; Schlaeger, C.; Lodygin, D.; Heckelsmiller, K.; Nietfeld, W.; Ellwart, J.; Klinkert, W. E. F. et al.; Lottaz, C.; Nosov, M.; Brinkmann, V.; Spang, R.; Lehrach, H.; Vingron, M.; Wekerle, H.; Fluegel-Koch, C.; Fluegel, A.: T cells become licensed in the lung to enter the central nervous system. Nature 488 (7413), pp. 675 - 679 (2012)

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Perera, N. C.; Jenne, D. E.: Perspectives and potential roles for the newly discovered NSP4 in the immune system. Expert Review of Clinical Immunology 8 (6), pp. 501 - 503 (2012)

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Perera, N. C.; Schilling, O.; Kittel, H.; Back, W.; Kremmer, E.; Jenne, D. E.: NSP4, an elastase-related protease in human neutrophils with arginine specificity. Proceedings of the National Academy of Sciences of the United States of America 109 (16), pp. 6229 - 6234 (2012)

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Schankin, C. J.; Reifferscheid, A. K.; Krumbholz, M.; Linn, J.; Rachinger, W.; Langer, S.; Sostak, P.; Arzberger, T.; Kretzschmar, H.; Straube, A.: Headache in patients with pituitary adenoma: Clinical and paraclinical findings. Cephalalgia 32 (16), pp. 1198 - 1207 (2012)

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Siewert, K.; Malotka, J.; Kawakami, N.; Wekerle, H.; Hohlfeld, R.; Dornmair, K.: Unbiased identification of target antigens of CD8(+) T cells with combinatorial libraries coding for short peptides. Nature Medicine 18 (5), pp. 824 - 828 (2012)

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Wekerle, H.; Fluegel, A.; Fugger, L.; Schett, G.; Serreze, D.: Autoimmunity's next top models. Nature Medicine 18 (1), pp. 66 - 70 (2012)

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Journal Article (381)