Publications of the emeritus-department "Neuroimmunology"

Berzi, A.; Ayata, C. K.; Cavalcante, P.; Falcone, C.; Candiago, E.; Motta, T.; Bernasconi, P.; Hohlfeld, R.; Mantegazza, R.; Meinl, E. et al.; Farina, C.: BDNF and its receptors in human myasthenic thymus: Implications for cell fate in thymic pathology. Journal of Neuroimmunology 197 (2), pp. 128 - 139 (2008)

Bourquin, C.; van der Haar, M. E.; Anz, D.; Sandholzer, N.; Neumaier, I.; Endres, S.; Skerra, A.; Schwab, M. E.; Linington, C.: DNA vaccination efficiently induces antibodies to Nogo-A and does not exacerbate experimental autoimmune encephalomyelitis. European Journal of Pharmacology 588 (1), pp. 99 - 105 (2008)

Breithaupt, C.; Schäfer, B.; Pellkofer, H.; Huber, R.; Linington, C.; Jacob, U.: Demyelinating myelin oligodendrocyte glycoprotein-specific autoantibody response is focused on one dominant conformational epitope region in rodents. Journal of Immunology 181 (2), pp. 1255 - 1263 (2008)

Deininger, K.; Eder, M.; Kramer, E. R.; Zieglgänsberger, W.; Dodt, H. U.; Dornmair, K.; Colicelli, J.; Klein, R.: The Rab5 guanylate exchange factor Rin1 regulates endocytosis of the EphA4 receptor in mature excitatory neurons. Proceedings of the National Academy of Sciences of the United States of America 105 (34), pp. 12539 - 12544 (2008)

Derfuss, T.; Direskeneli, G. S.; Hohlfeld, R.; Meinl, E.: Autoantigen- und erregerspezifische T- und B-Zellreaktionen bei multipler Sklerose: „Eine unendliche Geschichte”? Aktuelle Neurologie 35 (7), pp. 345 - 355 (2008)

Haghikia, A.; Fischer, M.; Hellwig, K.; Linker, R.; Chan, A.; Hohlfeld, R.; Gold, R.: Open use of natalizumab. Neutralising antibodies and clinical data. Nervenarzt 79 (6), pp. 716 - 719 (2008)

Hoffmann, L. A.; Lohse, P.; König, F. B.; Feneberg, W.; Hohlfeld, R.; Kümpfel, T.: TNFRSF1A R92Q mutation in association with a multiple sclerosis-like demyelinating syndrome. Neurology 70 (13 Pt 2), pp. 1155 - 1156 (2008)

Hohlfeld, R.: Neurotrophic cross-talk between the nervous and immune systems: Relevance for repair strategies in multiple sclerosis? Journal of the Neurological Sciences 265 (1-2), pp. 93 - 96 (2008)

Hohlfeld, R.; Meinl, E.; Dornmair, K.: B- and T-cell responses in multiple sclerosis: Novel approaches offer new insights. Journal of Neurological Sciences 274 (1-2), pp. 5 - 8 (2008)

Hohlfeld, R.; Wekerle, H.: Reflections on the "intrathymic pathogenesis" of myasthenia gravis. Journal of Neuroimmunology 201-202, pp. 21 - 27 (2008)

Jarius, S.; Paul, F.; Franciotta, D.; Waters, P.; Zipp, F.; Hohlfeld, R.; Vincent, A.; Wildemann, B.: Mechanisms of disease: Aquaporin-4 antibodies in neuromyelitis optica. Nature Clinical Practice Neurology 4 (4), pp. 202 - 214 (2008)

Jarius, S.; Stich, O.; Rasiah, C.; Voltz, R.; Rauer, S.: Qualitative evidence of Ri specific IgG-synthesis in the cerebrospinal fluid from patients with paraneoplastic neurological syndromes. Journal of the Neurological Sciences 268 (1-2), pp. 65 - 68 (2008)

Kessenbrock, K.; Fröhlich, L.; Sixt, M.; Lämmermann, T.; Pfister, H.; Bateman, A.; Belaaouaj, A.; Ring, J.; Ollert, M.; Fässler, R. et al.; Jenne, D. E.: Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin. Journal of Clinical Investigation 118 (7), pp. 2438 - 2447 (2008)

Korkmaz, B.; Kuhl, A.; Bayat, B.; Santoso, S.; Jenne, D. E.: A Hydrophobic Patch on Proteinase 3, the Target of Autoantibodies in Wegener Granulomatosis, Mediates Membrane Binding via NB1 Receptors. Journal of Biological Chemistry 283 (51), pp. 35976 - 35982 (2008)

Krumbholz, M.; Faber, H.; Steinmeyer, F.; Hoffmann, L. A.; Kümpfel, T.; Pellkofer, H.; Derfuss, T.; Ionescu, C.; Starck, M.; Hafner, C. et al.; Hohlfeld, R.; Meinl, E.: Interferon-β increases BAFF levels in multiple sclerosis: Implications for B cell autoimmunity. Brain 131, pp. 1455 - 1463 (2008)

Krumbholz, M.; Meinl, I.; Kümpfel, T.; Hohlfeld, R.; Meinl, E.: Natalizumab disproportionately increases circulating pre-B and B cells in multiple sclerosis. Neurology 71 (17), pp. 1350 - 1354 (2008)

Kuhl, A.; Melberg, A.; Meinl, E.; Nürnberg, G.; Nürnberg, P.; Kehrer-Sawatzki, H.; Jenne, D. E.: Myofibrillar myopathy with arrhythmogenic right ventricular cardiomyopathy 7: Corroboration and narrowing of the critical region on 10q22.3. European Journal of Human Genetics 16, pp. 367 - 373 (2008)

Kümpfel, T.; Hoffmann, L. A.; Pellkofer, H.; Pöllmann, W.; Feneberg, W.; Hohlfeld, R.; Lohse, P.: Multiple sclerosis and the TNFRSF1A R92Q mutation: Clinical characteristics of 21 cases. Neurology 71, pp. 1812 - 1820 (2008)

Kurschus, F. C.; Fellows, E.; Stegmann, E.; Jenne, D. E.: Granzyme B delivery via perforin is restricted by size, but not by heparan sullfate-dependent endocytosis. Proceedings of the National Academy of Sciences of the United States of America 105 (37), pp. 13799 - 13804 (2008)

Matheu, M. P.; Beeton, C.; Garcia, A.; Chi, V.; Rangaraju, S.; Safrina, O.; Monaghan, K.; Uemura, M. I.; Li, D.; Pal, S. et al.; de la Maza, L. M.; Monuki, E.; Flügel, A.; Pennington, M. W.; Parker, I.; Chandy, K. G.; Cahalan, M. D.: Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block. Immunity 29 (4), pp. 602 - 614 (2008)

Meinl, E.; Krumbholz, M.; Derfuss, T.; Junker, A.; Hohlfeld, R.: Compartmentalization of inflammation in the CNS: A major mechanism driving progressive multiple sclerosis. Journal of Neurological Sciences 274 (1-2), pp. 42 - 44 (2008)

Müller, N.; van den Brandt, J.; Odoardi, F.; Tischner, D.; Herath, J.; Flügel, A.; Reichardt, H. M.: A CD28 superagonistic antibody elicits 2 functionally distinct waves of T cell activation in rats. Journal of Clinical Investigation 118 (4), pp. 1405 - 1416 (2008)

Obermeier, B.; Malotka, J.; Dornmair, K.; Mentele, R.: Analysis of patient-specific immunoglobulin proteomes and transcriptomes by PCR cloning and mass spectometry. (2008)

Obermeier, B.; Malotka, J.; Kellermann, J.; Kümpfel, T.; Wekerle, H.; Lottspeich, F.; Mentele, R.; Hohlfeld, R.; Dornmair, K.: Matching of oligoclonal immunoglobulin transcriptomes and proteomes of cerebrospinal fluid in multiple sclerosis. Nature Medicine 14 (6), pp. 688 - 693 (2008)

Odoardi, F.; Cordiglieri, C.; Dammermann, W.; Zhang, B.; Hohenegger, M.; Potter, B. V.; Guse, A.; Flügel, A.: NAADP/Ca2+ signaling: A new therapeutic target for T cell mediated autoimmune disease. Wiener Klinische Wochenschrift 120 (Suppl. Suppl. 1), p. 54 - 54 (2008)

Riedl, J.; Crevenna, A. H.; Kessenbrock, K.; Yu, J. H.; Neukirchen, D.; Bista, M.; Bradke, F.; Jenne, D. E.; Holak, T. A.; Werb, Z. et al.; Sixt, M.; Wedlich-Söldner, R.: Lifeact: A versatile marker to visualize F-actin. Nature Methods 5 (7), pp. 605 - 607 (2008)

Rooney, G. E.; Moran, C.; McMahon, S. S.; Ritter, T.; Maenz, M.; Flügel, A.; Dockery, P.; O'Brien, T.; Howard, L.; Windebank, A. J. et al.; Barry, F. P.: Gene-modified mesenchymal stem cells express functionally active nerve growth factor on an engineered poly lactic glycolic acid (PLGA) substrate. Tissue Engineering Part A 14 (5), pp. 681 - 690 (2008)

Sommer, N.; Tackenberg, B.; Hohlfeld, R.: The immunopathogenesis of myasthenia gravis. Handb Clin Neurol 91 (Chapter 5), pp. 169 - 212 (2008)

Theil, D. J.; Libbey, J. E.; Rodriguez, F.; Whitton, J. L.; Tsunoda, I.; Derfuss, T.; Fujinami, R. S.: Targeting myelin proteolipid protein to the MHC class I pathway by ubiquitination modulates the course of experimental autoimmune encephalomyelitis. Journal of Neuroimmunology 204 (1-2), pp. 92 - 100 (2008)

Wiendl, H.; Toyka, K. V.; Rieckmann, P.; Gold, R.; Hartung, H. P.; Hohlfeld, R.: Basic and escalating immunomodulatory treatments in multiple sclerosis: Current therapeutic recommendations. Journal of Neurology 255 (10), pp. 1449 - 1463 (2008)

Bradl, M.; Dornmair, K.; Hohlfeld, R.: New tools for investigating the immunopathogenesis of MS: Principles and applications. In: Multiple Sclerosis: A Comprehensive Text, pp. 284 - 299 (Eds. Raine, C. S.; McFarland, H. F.; Hohlfeld, R.). Saunders, Elsevier, Edinburgh (2008)

Cordiglieri, C.: Role of NAADP-mediated calcium signalling in encephalitogenic T cells in EAE, an animal model for Multiple Sclerosis. Dissertation, Università degli Studi di Bologna, Bologna (2008)