Publications of Reinhard Hohlfeld

Journal Article (118)

2012
Journal Article
Bruder, J.; Siewert, K.; Obermeier, B.; Malotka, J.; Scheinert, P.; Kellermann, J.; Ueda, T.; Hohlfeld, R.; Dornmair, K.: Target specificity of an autoreactive pathogenic human gamma delta-T cell receptor in myositis. The Journal of Biological Chemistry 287 (25), pp. 20986 - 20995 (2012)
Journal Article
Colombo, E.; Cordiglieri, C.; Melli, G.; Newcombe, J.; Krumbholz, M.; Parada, L. F.; Medico, E.; Hohlfeld, R.; Meinl, E.; Farina, C.: Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration. Journal of Experimental Medicine 209 (3), pp. 521 - 535 (2012)
Journal Article
Eisele, S.; Krumbholz, M.; Fischer, M.-T.; Mohan, H.; Junker, A.; Arzberger, T.; Hohlfeld, R.; Bradl, M.; Lassmann, H.; Meinl, E.: Prospects of transcript profiling for mRNAs and microRNAs using formalin-fixed and paraffin-embedded dissected autoptic multiple sclerosis lesions. Brain Pathology 22 (5), pp. 607 - 618 (2012)
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Hohlfeld, R.: Ion channels boost axonal injury in multiple sclerosis. Nature Medicine 18 (12), pp. 1743 - 1745 (2012)
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Hohlfeld, R.; Wekerle, H.: beta-Amyloid: Enemy or Remedy? SCIENCE TRANSLATIONAL MEDICINE 4 (145), 145fs24 (2012)
Journal Article
Krumbholz, M.; Derfuss, T.; Hohlfeld, R.; Meinl, E.: B cells and antibodies in multiple sclerosis pathogenesis and therapy. Nature Reviews Neurology 8 (11), pp. 613 - 623 (2012)
Journal Article
Mayer, M. C.; Hohlfeld, R.; Meinl, E.: Viability of autoantibody-targets: How to tackle pathogenetic heterogeneity as an obstacle for treatment of multiple sclerosis. JOURNAL OF THE NEUROLOGICAL SCIENCES 319 (1-2), pp. 2 - 7 (2012)
Journal Article
Ng, J. K. M.; Malotka, J.; Kawakami, N.; Derfuss, T.; Khademi, M.; Olsson, T.; Linington, C.; Odaka, M.; Tackenberg, B.; Pruess, H. et al.; Schwab, J. M.; Harms, L.; Harms, H.; Sommer, C.; Rasband, M. N.; Eshed-Eisenbach, Y.; Peles, E.; Hohlfeld, R.; Yuki, N.; Dornmair, K.; Meinl, E.: Neurofascin as a target for autoantibodies in peripheral neuropathies. Neurology 79 (23), pp. 2241 - 2248 (2012)
Journal Article
Siewert, K.; Malotka, J.; Kawakami, N.; Wekerle, H.; Hohlfeld, R.; Dornmair, K.: Unbiased identification of target antigens of CD8(+) T cells with combinatorial libraries coding for short peptides. Nature Medicine 18 (5), pp. 824 - 828 (2012)
2011
Journal Article
Eisele, S.; Krumbholz, M.; Fischer, M.-T.; Mohan, H.; Junker, A.; Arzberger, T.; Hohlfeld, R.; Bradl, M.; Lassmann, H.; Meinl, E.: Prospects of transcript profiling for mRNAs and microRNAs using formalin fixed and paraffin embedded dissected autoptic multiple sclerosis lesions. Brain Pathology (accepted)
Journal Article
Ivanidze, J.; Hoffmann, R.; Lochmueller, H.; Engel, A. G.; Hohlfeld, R.; Dornmair, K.: Inclusion body myositis laser microdissection reveals differential up-regulation of IFN-gamma signaling cascade in attacked versus nonattacked myofibers. American Journal of Pathology 179 (3), pp. 1347 - 1359 (2011)
Journal Article
Junker, A.; Hohlfeld, R.; Meinl, E.: The emerging role of microRNAs in multiple sclerosis. Nature Reviews Neurology 7 (1), pp. 56 - 59 (2011)
Journal Article
Kümpfel, T.; Gerdes, L.; Flaig, M.; Hohlfeld, R.; Wollenberg, A.: Drug-induced Sweet's syndrome after mitoxantrone therapy in a patient with multiple sclerosis. Multiple Sclerosis Journal 17 (4), pp. 495 - 497 (2011)
Journal Article
Meinl, E.; Derfuss, T.; Krumbholz, M.; Pröbstel, A. K.; Hohlfeld, R.: Humoral autoimmunity in multiple sclerosis. Journal of the Neurological Sciences 306 (1-2), pp. 180 - 182 (2011)
Journal Article
Obermeier, B.; Lovato, L.; Bruck, W.; Forne, I.; Imhof, A.; Mentele, R.; Lottspeich, F.; Turk, K. W.; Willis, S. N.; Wekerle, H. et al.; Hohlfeld, R.; Hafler, D. A.; O'Connor, K. C.; Dornmair, K.: Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin. Journal of Neuroimmunology 233 (1-2), pp. 245 - 248 (2011)
Journal Article
Pellkofer, H. L.; Krumbholz, M.; Berthele, A.; Hemmer, B.; Gerdes, L. A.; Havla, J.; Bittner, R.; Canis, M.; Meinl, E.; Hohlfeld, R. et al.; Kuempfel, T.: Long-term follow-up of patients with neuromyelitis optica after repeated therapy with rituximab. Neurology 76 (15), pp. 1310 - 1315 (2011)
Journal Article
Pröbstel, A.-K.; Dornmair, K.; Bittner, R.; Sperl, P.; Jenne, D. E.; Magalhaes, S.; Villalobos, A.; Breithaupt, C.; Weissert, R.; Jacob, U. et al.; Krumbholz, M.; Kuempfel, T.; Blaschek, A.; Stark, W.; Gaertner, J.; Pohl, D.; Rostasy, K.; Weber, F.; Forne, I.; Khademi, M.; Olsson, T.; Brilot, F.; Tantsis, E.; Dale, R. C.; Wekerle, H.; Hohlfeld, R.; Banwell, B.; Bar-Or, A.; Meinl, E.; Derfuss, T.: Antibodies to MOG are transient in childhood acute disseminated encephalomyelitis. Neurology 77 (6), pp. 580 - 588 (2011)
2010
Journal Article
Blaschek, A.; Lohse, P.; Huss, K.; Borggraefe, I.; Mueller-Felber, W.; Heinen, F.; Hohlfeld, R.; Kümpfel, T.: Concurrent TNFRSF1A R92Q and pyrin E230K mutations in a child with multiple sclerosis. Multiple Sclerosis 16 (12), pp. 1517 - 1520 (2010)
Journal Article
Derfuss, T.; Linington, C.; Hohlfeld, R.; Meinl, E.: Axo-glial antigens as targets in multiple sclerosis: implications for axonal and grey matter injury. Journal of Molecular Medicine 88 (8), pp. 753 - 761 (2010)
Journal Article
Hohlfeld, R.: 'Gimme five': future challenges in multiple sclerosis. ECTRIMS Lecture 2009. Multiple Sclerosis 16 (1), pp. 3 - 14 (2010)
Journal Article
Kappos, L.; Radue, E. W.; O'Connor, P.; Polman, C.; Hohlfeld, R.; Calabresi, P.; Selmaj, K.; Agoropoulou, C.; Leyk, M.; Zhang-Auberson, L. et al.; Burtin, P.: A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis. New England Journal of Medicine 362 (5), pp. 387 - 401 (2010)
Journal Article
Mohan, H.; Krumbholz, M.; Sharma, R.; Eisele, S.; Junker, A.; Sixt, M.; Newcombe, J.; Wekerle, H.; Hohlfeld, R.; Lassmann, H. et al.; Meinl, E.: Extracellular matrix in multiple sclerosis lesions: Fibrillar collagens, biglycan and decorin are upregulated and associated with infiltrating immune cells. Brain Pathology 20 (5), pp. 966 - 975 (2010)
Journal Article
Wekerle, H.; Hohlfeld, R.: Beneficial brain autoimmunity? Brain 133, pp. 2182 - 2184 (2010)
Journal Article
Wekerle, H.; Hohlfeld, R.: Molecular oracles for multiple sclerosis therapy. Nature Medicine 16 (4), pp. 376 - 377 (2010)
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Wekerle, H.; Hohlfeld, R.: Zero Tolerance (to Acetylcholine Receptor) and Ways to Overcome It. Annals of Neurology 67 (4), pp. 422 - 424 (2010)
2009
Journal Article
Derfuss, T.; Parikh, K.; Velhin, S.; Braun, M.; Mathey, E.; Krumbholz, M.; Kümpfel, T.; Moldenhauer, A.; Rader, C.; Sonderegger, P. et al.; Pöllmann, W.; Tiefenthaller, C.; Bauer, J.; Lassmann, H.; Wekerle, H.; Karagogeos, D.; Hohlfeld, R.; Linington, C.; Meinl, E.: Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals. Proceedings of the National Academy of Sciences of the United States of America 106 (20), pp. 8302 - 8307 (2009)
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Dornmair, K.; Meinl, E.; Hohlfeld, R.: Novel approaches for identifying target antigens of autoreactive human B and T cells. Seminars in Immunopathology 31 (4), pp. 467 - 477 (2009)
Journal Article
Hohlfeld, R.: Multiple sclerosis: Human model for EAE? European Journal of Immunology 39 (8), pp. 2036 - 2039 (2009)
Journal Article
Junker, A.; Krumbholz, M.; Eisele, S.; Mohan, H.; Augstein, F.; Bittner, R.; Lassmann, H.; Wekerle, H.; Hohlfeld, R.; Meinl, E.: MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47. Brain 132, pp. 3342 - 3352 (2009)
Journal Article
Kerschensteiner, M.; Meinl, E.; Hohlfeld, R.: Neuro-immune crosstalk in CNS. Neuroscience 158 (3), pp. 1122 - 1132 (2009)
Journal Article
Pellkofer, H. L.; Voltz, R.; Goebels, N.; Hohlfeld, R.; Dornmair, K.: Cross-reactive T-Cell Receptors in Tumor and Paraneoplastic Target Tissue. Archives of Neurology 66 (5), pp. 655 - 658 (2009)
2008
Journal Article
Berzi, A.; Ayata, C. K.; Cavalcante, P.; Falcone, C.; Candiago, E.; Motta, T.; Bernasconi, P.; Hohlfeld, R.; Mantegazza, R.; Meinl, E. et al.; Farina, C.: BDNF and its receptors in human myasthenic thymus: Implications for cell fate in thymic pathology. Journal of Neuroimmunology 197 (2), pp. 128 - 139 (2008)
Journal Article
Derfuss, T.; Direskeneli, G. S.; Hohlfeld, R.; Meinl, E.: Autoantigen- und erregerspezifische T- und B-Zellreaktionen bei multipler Sklerose: „Eine unendliche Geschichte”? Aktuelle Neurologie 35 (7), pp. 345 - 355 (2008)
Journal Article
Haghikia, A.; Fischer, M.; Hellwig, K.; Linker, R.; Chan, A.; Hohlfeld, R.; Gold, R.: Open use of natalizumab. Neutralising antibodies and clinical data. Nervenarzt 79 (6), pp. 716 - 719 (2008)
Journal Article
Hoffmann, L. A.; Lohse, P.; König, F. B.; Feneberg, W.; Hohlfeld, R.; Kümpfel, T.: TNFRSF1A R92Q mutation in association with a multiple sclerosis-like demyelinating syndrome. Neurology 70 (13 Pt 2), pp. 1155 - 1156 (2008)
Journal Article
Hohlfeld, R.: Neurotrophic cross-talk between the nervous and immune systems: Relevance for repair strategies in multiple sclerosis? Journal of the Neurological Sciences 265 (1-2), pp. 93 - 96 (2008)
Journal Article
Hohlfeld, R.; Meinl, E.; Dornmair, K.: B- and T-cell responses in multiple sclerosis: Novel approaches offer new insights. Journal of Neurological Sciences 274 (1-2), pp. 5 - 8 (2008)
Journal Article
Hohlfeld, R.; Wekerle, H.: Reflections on the "intrathymic pathogenesis" of myasthenia gravis. Journal of Neuroimmunology 201-202, pp. 21 - 27 (2008)
Journal Article
Jarius, S.; Paul, F.; Franciotta, D.; Waters, P.; Zipp, F.; Hohlfeld, R.; Vincent, A.; Wildemann, B.: Mechanisms of disease: aquaporin-4 antibodies in neuromyelitis optica. Nat Clin Pract Neurol 4 (4), pp. 202 - 214 (2008)
Journal Article
Krumbholz, M.; Faber, H.; Steinmeyer, F.; Hoffmann, L. A.; Kümpfel, T.; Pellkofer, H.; Derfuss, T.; Ionescu, C.; Starck, M.; Hafner, C. et al.; Hohlfeld, R.; Meinl, E.: Interferon-beta increases BAFF levels in multiple sclerosis: implications for B cell autoimmunity. Brain 131, pp. 1455 - 1463 (2008)
Journal Article
Krumbholz, M.; Meinl, I.; Kümpfel, T.; Hohlfeld, R.; Meinl, E.: Natalizumab disproportionately increases circulating pre-B and B cells in multiple sclerosis. Neurology 71 (17), pp. 1350 - 1354 (2008)
Journal Article
Kümpfel, T.; Hoffmann, L. A.; Pellkofer, H.; Pöllmann, W.; Feneberg, W.; Hohlfeld, R.; Lohse, P.: Multiple sclerosis and the TNFRSF1A R92Q mutation: clinical characteristics of 21 cases. Neurology 71, 1820, pp. 22 - 1812 (2008)
Journal Article
Meinl, E.; Krumbholz, M.; Derfuss, T.; Junker, A.; Hohlfeld, R.: Compartmentalization of inflammation in the CNS: A major mechanism driving progressive multiple sclerosis. Journal of Neurological Sciences 274 (1-2), pp. 42 - 44 (2008)
Journal Article
Obermeier, B.; Malotka, J.; Kellermann, J.; Kümpfel, T.; Wekerle, H.; Lottspeich, F.; Mentele, R.; Hohlfeld, R.; Dornmair, K.: Matching of oligoclonal immunoglobulin transcriptomes and proteomes of cerebrospinal fluid in multiple sclerosis. Nature Medicine 14 (6), pp. 688 - 693 (2008)
Journal Article
Sommer, N.; Tackenberg, B.; Hohlfeld, R.: The immunopathogenesis of myasthenia gravis. Handb Clin Neurol 91 (Chapter 5), pp. 169 - 212 (2008)
Journal Article
Wiendl, H.; Toyka, K. V.; Rieckmann, P.; Gold, R.; Hartung, H. P.; Hohlfeld, R.: Basic and escalating immunomodulatory treatments in multiple sclerosis: current therapeutic recommendations. Journal of Neurology 255 (10), pp. 1449 - 1463 (2008)
2007
Journal Article
Hoffmann, L. A.; Krumbholz, M.; Faber, H.; Kuempfel, T.; Starck, M.; Pöllmann, W.; Meinl, E.; Hohlfeld, R.: Multiple sclerosis: relating MxA transcription to anti-interferon-beta-neutralizing antibodies. Neurology 68 (12), pp. 958 - 959 (2007)
Journal Article
Hohlfeld, R.; Dornmair, K.: Revisiting the immunopathogenesis of the inflammatory myopathies. Neurology 69 (21), pp. 1966 - 1967 (2007)
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Hohlfeld, R.; Kerschensteiner, M.; Meinl, E.: Dual role of inflammation in CNS disease. Neurology 68 (3), pp. 58 - 63 (2007)
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Jarius, S.; Eichhorn, P.; Albert, M. H.; Wagenpfeil, S.; Wick, M.; Belohradsky, B. H.; Hohlfeld, R.; Jenne, D. E.; Voltz, R.: Intravenous immunoglobulins contain naturally occurring antibodies that mimic antineutrophil cytoplasmic antibodies and activate neutrophils in a TNF alpha-dependent and Fc-receptor-independent way. Blood 109 (10), pp. 4376 - 4382 (2007)
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