Publications of Dieter E. Jenne

Journal Article (77)

2022
Journal Article
Kessler, N.; Viehmann, S. F.; Krollmann, C.; Mai, K.; Kirschner, K. M.; Luksch, H.; Kotagiri, P.; Bohner, A. M. C.; Huugen, D.; de Oliveira Mann, C. C. et al.; Otten, S.; Weiss, S. A. I.; Zillinger, T.; Dobrikova, K.; Jenne, D. E.; Behrendt, R.; Ablasser, A.; Bartok, E.; Hartmann, G.; Hopfner, K.-P.; Lyons, P. A.; Boor, P.; Rosen-Wolff, A.; Teichmann, L. L.; Heeringa, P.; Kurts, C.; Garbi, N.: Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing. The Journal of experimental medicine 219 (10), e20220759 (2022)
2021
Journal Article
Granel, J.; Korkmaz, B.; Nouar, D.; Weiss, S. A. I.; Jenne, D. E.; Lemoine, R.; Hoarau, C.: Pathogenicity of proteinase 3-anti-neutrophil cytoplasmic antibody in granulomatosis with polyangiitis: Implications as biomarker and future therapies. Frontiers in immunology 12, 571933 (2021)
Journal Article
Korkmaz, B.; Lamort, A.-S.; Domain, R.; Beauvillain, C.; Gieldon, A.; Yildirim, A. O.; Stathopoulos, G. T.; Rhimi, M.; Jenne, D. E.; Kettritz, R.: Cathepsin C inhibition as a potential treatment strategy in cancer. Biochemical Pharmacology 194, p. 114803 - 114803 (2021)
Journal Article
Morrone, C.; Smirnova, N. F.; Jeridi, A.; Kneidinger, N.; Hollauer, C.; Schupp, J. C.; Kaminski, N.; Jenne, D.; Eickelberg, O.; Yildirim, A. O.: Cathepsin B promotes collagen biosynthesis, which drives bronchiolitis obliterans syndrome. European Respiratory Journal 57 (5), 2001416 (2021)
Journal Article
Schoeps, B.; Eckfeld, C.; Prokopchuk, O.; Boettcher, J.; Haeussler, D.; Steiger, K.; Demir, I. E.; Knolle, P.; Soehnlein, O.; Jenne, D. E. et al.; Hermann, C. D.; Krueger, A.: TIMP1 triggers neutrophil extracellular trap formation in pancreatic cancer. Cancer Research 81 (13), pp. 3568 - 3579 (2021)
Journal Article
Seren, S.; Derian, L.; Keles, I.; Guillon, A.; Lesner, A.; Gonzalez, L.; Baranek, T.; Si-Tahar, M.; Marchand-Adam, S.; Jenne, D. E. et al.; Paget, C.; Jouan, Y.; Korkmaz, B.: Proteinase release from activated neutrophils in mechanically ventilated patients with non-COVID-19 and COVID-19 pneumonia. European Respiratory Journal 57 (4), 2003755 (2021)
Journal Article
Weiss, S. A. I.; Rehm, S. R. T.; Perera, N. C.; Biniossek, M. L.; Schilling, O.; Jenne, D. E.: Origin and expansion of the serine protease repertoire in the myelomonocyte lineage. International Journal of Molecular Sciences 22 (4), 1658 (2021)
2020
Journal Article
Korkmaz, B.; Lesner, A.; Marchand-Adam, S.; Moss, C.; Jenne, D. E.: Lung protection by cathepsin C inhibition: A new hope for COVID-19 and ARDS? Journal of Medicinal Chemistry 63 (22), pp. 13258 - 13265 (2020)
2019
Journal Article
Fernandez, I. M.; Macrini, C.; Krumbholz, M.; Hensbergen, P. J.; Ederveen, A. L. H.; Winklmeier, S.; Vural, A.; Kurne, A.; Jenne, D. E.; Kamp, F. et al.; Gerdes, L. A.; Hohlfeld, R.; Wuhrer, M.; Kümpfel, T.; Meinl, E.: The glycosylation site of myelin oligodendrocyte glycoprotein affects autoantibody recognition in a large proportion of patients. Frontiers in immunology 10, 1189 (2019)
Journal Article
Korkmaz, B.; Lesner, A.; Wysocka, M.; Gieldon, A.; Hakansson, M.; Gauthier, F.; Logan, D. T.; Jenne, D. E.; Lauritzen, C.; Pedersen, J.: Structure-based design and in vivo anti-arthritic activity evaluation of a potent dipeptidyl cyclopropyl nitrile inhibitor of cathepsin C. Biochemical Pharmacology 164, pp. 349 - 367 (2019)
Journal Article
Lamort, A.-S.; Hamon, Y.; Czaplewski, C.; Gieldon, A.; Seren, S.; Coquet, L.; Lecaille, F.; Lesner, A.; Lalmanach, G.; Gauthier, F. et al.; Jenne, D. E.; Korkmaz, B.: Processing and maturation of cathepsin C zymogen: A biochemical and molecular modeling analysis. International Journal of Molecular Sciences 20 (19), 4747 (2019)
Journal Article
Rehm, S. R. T.; Smirnova, N. F.; Morrone, C.; Goetzfried, J.; Feuchtinger, A.; Pedersen, J.; Korkmaz, B.; Yildirim, A. O.; Jenne, D. E.: Premedication with a cathepsin C inhibitor alleviates early primary graft dysfunction in mouse recipients after lung transplantation. Scientific Reports 9, 9925 (2019)
2018
Journal Article
Goetzfried, J.; Smirnova, N. F.; Morrone, C.; Korkmaz, B.; Yildirim, A. O.; Eickelberg, O.; Jenne, D. E.: Preservation with alpha(1)-antitrypsin improves primary graft function of murine lung transplants. The Journal of Heart and Lung Transplantation 37 (8), pp. 1021 - 1028 (2018)
Journal Article
Guarino, C.; Gruba, N.; Grzywa, R.; Dyguda-Kazimierowicz, E.; Hamon, Y.; Legowska, M.; Skorenski, M.; Dallet-Choisy, S.; Marchand-Adam, S.; Kellenberger, C. et al.; Jenne, D. E.; Sienczyk, M.; Lesner, A.; Gauthier, F.; Korkmaz, B.: Exploiting the S4-S5 specificity of human neutrophil proteinase 3 to improve the potency of deptidyl Di(chlorophenyl)-phosphonate ester inhibitors: A kinetic and molecular modeling analysis. Journal of Medicinal Chemistry 61 (5), pp. 1858 - 1870 (2018)
Journal Article
Seren, S.; Abouzaid, M. R.; Eulenberg-Gustavus, C.; Hirschfeld, J.; Soliman, H. N.; Jerke, U.; N'Guessan, K.; Dallet-Choisy, S.; Lesner, A.; Lauritzen, C. et al.; Schacher, B.; Eickholz, P.; Nagy, N.; Szell, M.; Croix, C.; Viaud-Massuard, M.-C.; Aldosari, A. A. F.; Ragunatha, S.; Mostafa, M. I.; Giampieri, F.; Battino, M.; Cornillier, H.; Lorette, G.; Stephan, J.-L.; Goizet, C.; Pedersen, J.; Gauthier, F.; Jenne, D. E.; Marchand-Adam, S.; Chapple, I. L.; Kettritz, R.; Korkmaz, B.: Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis. The Journal of Biological Chemistry 293 (32), pp. 12415 - 12428 (2018)
Journal Article
Spadaro, M.; Winklmeier, S.; Beltran, E.; Macrini, C.; Hoeftberger, R.; Schuh, E.; Thaler, F. S.; Gerdes, L. A.; Laurent, S.; Gerhards, R. et al.; Braendle, S.; Dornmair, K.; Breithaupt, C.; Krumbholz, M.; Moser, M.; Krishnamoorthy, G.; Kamp, F.; Jenne, D. E.; Hohlfeld, R.; Kuempfel, T.; Lassmann, H.; Kawakami, N.; Meinl, E.: Pathogenicity of human antibodies against myelin oligodendrocyte glycoprotein. Annals of Neurology 84 (2), pp. 315 - 328 (2018)
2017
Journal Article
Guarino, C.; Hamon, Y.; Croix, C.; Lamort, A.-S.; Dallet-Choisy, S.; Marchand-Adam, S.; Lesner, A.; Baranek, T.; Viaud-Massuard, M.-C.; Lauritzen, C. et al.; Pedersen, J.; Heuze-Vourc'h, N.; Si-Tahar, M.; Firatli, E.; Jenne, D. E.; Gauthier, F.; Horwitz, M. S.; Borregaard, N.; Korkmaz, B.: Prolonged pharmacological inhibition of cathepsin C results in elimination of neutrophil serine proteases. Biochemical Pharmacology 131, pp. 52 - 67 (2017)
2016
Journal Article
Dau, T.; Edeleva, E. V.; Seidel, S. A. I.; Stockley, R. A.; Braun, D.; Jenne, D. E.: Quantitative analysis of protease recognition by inhibitors in plasma using microscale thermophoresis. Scientific Reports 6, 35413 (2016)
Journal Article
Hamon, Y.; Legowska, M.; Fergelot, P.; Dallet-Choisy, S.; Newell, L.; Vanderlynden, L.; Valeshabad, A. K.; Acrich, K.; Kord, H.; Charalampos, T. et al.; Morice-Picard, F.; Surplice, I.; Zoidakis, J.; David, K.; Vlahou, A.; Ragunatha, S.; Nagy, N.; Farkas, K.; Szell, M.; Goizet, C.; Schacher, B.; Battino, M.; Aldosari, A. A. F.; Wang, X.; Liu, Y.; Marchand-Adam, S.; Lesner, A.; Kara, E.; Korkmaz-Icoez, S.; Moss, C.; Eickholz, P.; Taieb, A.; Kavukcu, S.; Jenne, D. E.; Gauthier, F.; Korkmaz, B.: Analysis of urinary cathepsin C for diagnosing Papillon-Lefevre syndrome. The FEBS Journal 283 (3), pp. 498 - 509 (2016)
Journal Article
Hamon, Y.; Legowska, M.; Herve, V.; Dallet-Choisy, S.; Marchand-Adam, S.; Vanderlynden, L.; Demonte, M.; Williams, R.; Scott, C. J.; Si-Tahar, M. et al.; Heuze-Vourc'h, N.; Lalmanach, G.; Jenne, D. E.; Lesner, A.; Gauthier, F.; Korkmaz, B.: Neutrophilic cathepsin C is maturated by a multistep proteolytic process and secreted by activated cells during inflammatory lung diseases. The Journal of Biological Chemistry 291 (16), pp. 8486 - 8499 (2016)
Journal Article
Korkmaz, B.; Lesner, A.; Guarino, C.; Wysocka, M.; Kellenberger, C.; Watier, H.; Specks, U.; Gauthier, F.; Jenne, D. E.: Inhibitors and antibody fragments as potential anti-inflammatory therapeutics targeting neutrophil proteinase 3 in human disease. Pharmacological Reviews 68 (3), pp. 603 - 630 (2016)
2015
Journal Article
Dau, T.; Sarker, R. S. J.; Yildirim, A. O.; Eickelberg, O.; Jenne, D. E.: Autoprocessing of neutrophil elastase near its active site reduces the efficiency of natural and synthetic elastase inhibitors. Nature Communications 6, 6722 (2015)
Journal Article
Hinkofer, L. C.; Hummel, A. M.; Stone, J. H.; Hoffman, G. S.; Merkel, P. A.; Spiera, E. R. F.; Clair, W. S.; McCune, J. W.; Davis, J. C.; Specks, U. et al.; Jenne, D. E.: Allosteric modulation of proteinase 3 activity by anti-neutrophil cytoplasmic antibodies in granulomatosis with polyangiitis. Journal of Autoimmunity 59, pp. 43 - 52 (2015)
2014
Journal Article
Guarino, C.; Legowska, M.; Epinette, C.; Kellenberger, C.; Dallet-Choisy, S.; Sienczyk, M.; Gabant, G.; Cadene, M.; Zoidakis, J.; Vlahou, A. et al.; Wysocka, M.; Marchand-Adam, S.; Jenne, D. E.; Lesner, A.; Gauthier, F.; Korkmaz, B.: New selective peptidyl Di(chlorophenyl) phosphonate esters for visualizing and blocking neutrophil proteinase 3 in human diseases. The Journal of Biological Chemistry 289 (46), pp. 31777 - 31791 (2014)
Journal Article
Guyot, N.; Wartelle, J.; Malleret, L.; Todorov, A. A.; Devouassoux, G.; Pacheco, Y.; Jenne, D. E.; Belaaouaj, A.: Unopposed cathepsin G, neutrophil elastase, and proteinase 3 cause severe lung damage and emphysema. American Journal of Pathology 184 (8), pp. 2197 - 2210 (2014)
Journal Article
Jenne, D. E.: Off-Target Rewards of Augmentation Therapy with alpha 1-Antitrypsin. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 190 (11), pp. 1203 - 1204 (2014)
2013
Journal Article
Hedberg, C.; Melberg, A.; Kuhl, A.; Jenne, D. E.; Oldfors, A.: Functional characterization of desmin mutant p.P419S Reply [Letter]. European journal of human genetics 21 (6), p. 590 - 590 (2013)
Journal Article
Hinkofer, L. C.; Seidel, S. A. I.; Korkmaz, B.; Silva, F.; Hummel, A. M.; Braun, D.; Jenne, D. E.; Specks, U.: A monoclonal antibody (MCPR3-7) interfering with the activity of proteinase 3 by an allosteric mechanism. The Journal of Biological Chemistry 288 (37), pp. 26635 - 26648 (2013)
Journal Article
O'Donoghue, A. J.; Jin, Y.; Knudsen, G. M.; Perera, N. C.; Jenne, D. E.; Murphy, J. E.; Craik, C. S.; Hermiston, T. W.: Global substrate profiling of proteases in human neutrophil extracellular traps reveals consensus motif predominantly contributed by elastase. PLoS One 8 (9), e75141 (2013)
Journal Article
Perera, N. C.; Wiesmueller, K.-H.; Larsen, M. T.; Schacher, B.; Eickholz, P.; Borregaard, N.; Jenne, D. E.: NSP4 is stored in azurophil granules and released by activated neutrophils as active endoprotease with restricted specificity. Journal of Immunology 191 (5), pp. 2700 - 2707 (2013)
2012
Journal Article
Hedberg, C.; Melberg, A.; Kuhl, A.; Jenne, D. E.; Oldfors, A.: Autosomal dominant myofibrillar myopathy with arrhythmogenic right ventricular cardiomyopathy 7 is caused by a DES mutation. European journal of human genetics 20 (9), pp. 984 - 985 (2012)
Journal Article
Lippok, S.; Seidel, S. A. I.; Duhr, S.; Uhland, K.; Holthoff, H.-P.; Jenne, D. E.; Braun, D.: Direct detection of antibody concentration and affinity in human serum using microscale thermophoresis. Analytical Chemistry 84 (8), pp. 3523 - 3530 (2012)
Journal Article
Mankan, A. K.; Dau, T.; Jenne, D. E.; Hornung, V.: The NLRP3/ASC/Caspase-1 axis regulates IL-1 ss processing in neutrophils. European Journal of Immunology 42 (3), pp. 710 - 715 (2012)
Journal Article
Perera, N. C.; Jenne, D. E.: Perspectives and potential roles for the newly discovered NSP4 in the immune system. EXPERT REVIEW OF CLINICAL IMMUNOLOGY 8 (6), pp. 501 - 503 (2012)
Journal Article
Perera, N. C.; Schilling, O.; Kittel, H.; Back, W.; Kremmer, E.; Jenne, D. E.: NSP4, an elastase-related protease in human neutrophils with arginine specificity. Proceedings of the National Academy of Sciences of the United States of America 109 (16), pp. 6229 - 6234 (2012)
2011
Journal Article
Croker, B. A.; Lewis, R. S.; Babon, J. J.; Mintern, J. D.; Jenne, D. E.; Metcalf, D.; Zhang, J. G.; Cengia, L. H.; O'Donnell, J. A.; Roberts, A. W.: Neutrophils Require SHP1 To Regulate IL-1 beta Production and Prevent Inflammatory Skin Disease. Journal of Immunology 186 (2), pp. 1131 - 1139 (2011)
Journal Article
Kessenbrock, K.; Dau, T.; Jenne, D. E.: Tailor-made inflammation: How neutrophil serine proteases modulate the inflammatory response. Journal of Molecular Medicine 89 (1), pp. 23 - 28 (2011)
Journal Article
Motta, J. P.; Magne, L.; Descamps, D.; Rolland, C.; Squarzoni-Dale, C.; Rousset, P.; Martin, L.; Cenac, N.; Balloy, V.; Huerre, M. et al.; Frohlich, L. F.; Jenne, D.; Wartelle, J.; Belaaouaj, A.; Mas, E.; Vinel, J. P.; Alric, L.; Chignard, M.; Vergnolle, N.; Sallenave, J. M.: Modifying the Protease, Antiprotease Pattern by Elafin Overexpression Protects Mice From Colitis. Gastroenterology 140 (4), pp. 1272 - 1282 (2011)
Journal Article
Pröbstel, A.-K.; Dornmair, K.; Bittner, R.; Sperl, P.; Jenne, D. E.; Magalhaes, S.; Villalobos, A.; Breithaupt, C.; Weissert, R.; Jacob, U. et al.; Krumbholz, M.; Kuempfel, T.; Blaschek, A.; Stark, W.; Gaertner, J.; Pohl, D.; Rostasy, K.; Weber, F.; Forne, I.; Khademi, M.; Olsson, T.; Brilot, F.; Tantsis, E.; Dale, R. C.; Wekerle, H.; Hohlfeld, R.; Banwell, B.; Bar-Or, A.; Meinl, E.; Derfuss, T.: Antibodies to MOG are transient in childhood acute disseminated encephalomyelitis. Neurology 77 (6), pp. 580 - 588 (2011)
2010
Journal Article
Korkmaz, B.; Horwitz, M. S.; Jenne, D. E.; Gauthier, F.: Neutrophil Elastase, Proteinase 3, and Cathepsin G as Therapeutic Targets in Human Diseases. Pharmacological Reviews 62 (4), pp. 726 - 759 (2010)
Journal Article
Kuhl, A.; Korkmaz, B.; Utecht, B.; Kniepert, A.; Schonermarck, U.; Specks, U.; Jenne, D. E.: Mapping of Conformational Epitopes on Human Proteinase 3, the Autoantigen of Wegener's Granulomatosis. Journal of Immunology 185 (1), pp. 387 - 399 (2010)
Journal Article
Kurschus, F. C.; Jenne, D. E.: Delivery and therapeutic potential of human granzyme B. Immunological Reviews 235, pp. 159 - 171 (2010)
Journal Article
Silva, F.; Hummel, A. M.; Jenne, D. E.; Specks, U.: Discrimination and variable impact of ANCA binding to different surface epitopes on proteinase 3, the Wegener's autoantigen. Journal of Autoimmunity 35 (4), pp. 299 - 308 (2010)
2009
Journal Article
Kessenbrock, K.; Krumbholz, M.; Schönermarck, U.; Back, W.; Gross, W. L.; Werb, Z.; Gröne, H. J.; Brinkmann, V.; Jenne, D. E.: Netting neutrophils in autoimmune small-vessel vasculitis. Nature Medicine 15 (6), pp. 623 - 625 (2009)
Journal Article
Kurschus, F. C.; Pal, P. P.; Bäumler, P.; Jenne, D. E.; Wiltschi, B.; Budisa, N.: Gold Fluorescent Annexin A5 as a Novel Apoptosis Detection Tool. Cytometry Part A 75A (7), pp. 626 - 633 (2009)
Journal Article
Romero, V.; Fellows, E.; Jenne, D. E.; Andrade, F.: Cleavage of La protein by granzyme H induces cytoplasmic translocation and interferes with La-mediated HCV-IRES translational activity. Cell Death and Differentiation 16 (2), pp. 340 - 348 (2009)
2008
Journal Article
Kessenbrock, K.; Fröhlich, L.; Sixt, M.; Lämmermann, T.; Pfister, H.; Bateman, A.; Belaaouaj, A.; Ring, J.; Ollert, M.; Fässler, R. et al.; Jenne, D. E.: Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin. Journal of Clinical Investigation 118 (7), pp. 2438 - 2447 (2008)
Journal Article
Korkmaz, B.; Kuhl, A.; Bayat, B.; Santoso, S.; Jenne, D. E.: A Hydrophobic Patch on Proteinase 3, the Target of Autoantibodies in Wegener Granulomatosis, Mediates Membrane Binding via NB1 Receptors. Journal of Biological Chemistry 283 (51), pp. 35976 - 35982 (2008)
Journal Article
Kuhl, A.; Melberg, A.; Meinl, E.; Nürnberg, G.; Nürnberg, P.; Kehrer-Sawatzki, H.; Jenne, D. E.: Myofibrillar myopathy with arrhythmogenic right ventricular cardiomyopathy 7: corroboration and narrowing of the critical region on 10q22.3. European Journal of Human Genetics 16, pp. 367 - 373 (2008)
Journal Article
Kurschus, F. C.; Fellows, E.; Stegmann, E.; Jenne, D. E.: Granzyme B delivery via perforin is restricted by size, but not by heparan sullfate-dependent endocytosis. Proceedings of the National Academy of Sciences of the United States of America 105 (37), pp. 13799 - 13804 (2008)
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