Max Planck Institute for Biological Intelligence

Publications of Rüdiger Klein

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Journal Article (190)

1.

Journal Article

Blumenstock, S.; Arakelyan, D.; del Grosso, N.; Schneider, S.; Shao, Y.; Gjoni, E.; Klein, R.; Dudanova, I.; Komiyama, T.: Optogenetic restoration of neuron subtype-specific cortical activity ameliorates motor deficits in Huntington’s Disease mice. bioRxiv: the preprint server for biology (2025)

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2.

Journal Article

Chun, S. H.; Diaz Almeida, D. S.; Todorov, M. I.; Straub, T.; Ruff, T.; Shao, W.; Yang, J.; Seyit-Bremer, G.; Shen, Y.-J.; Ertürk, A. et al.; del Toro, D.; Shi, S.; Klein, R.: Cortex folding by combined progenitor expansion and adhesion-controlled neuronal migration. bioRxiv: the preprint server for biology (2025)

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3.

Journal Article

Fermani, F.; Chang, S.; Mastrodicasa, Y.; Peters, C.; Gaitanos, L.; Alcala Morales, P. L.; Ramakrishnan, C.; Deisseroth, K.; Klein, R.: Food and water intake are regulated by distinct central amygdala circuits revealed using intersectional genetics. Nature Communications 16, 3072 (2025)

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4.

Journal Article

Murcia-Belmonte, V.; Chauvin, G.; Coca, Y.; Escalante, A.; Klein, R.; Herrera, E.: EphA4 mediates ephrinB1-dependent adhesion in retinal ganglion cells. The Journal of Neuroscience 45 (4), e0043242024 (2025)

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5.

Journal Article

Ding, W.; Weltzien, H.; Peters, C.; Klein, R.: Nausea-induced suppression of feeding is mediated by central amygdala Dlk1-expressing neurons. Cell Reports 43 (4), 113990 (2024)

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6.

Journal Article

Lim, H.; Zhang, Y.; Peters, C.; Straub, T.; Mayer, J. L.; Klein, R.: Genetically- and spatially-defined basolateral amygdala neurons control food consumption and social interaction. Nature Communications 15, 6868 (2024)

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7.

Journal Article

Shen, Y.-J.; Zaballa, S.; Bech, X.; Sancho-Balsells, A.; Rodriguez-Navarro, I.; Cifuentes-Diaz, C.; Seyit-Bremer, G.; Chun, S. H.; Straub, T.; Abante, J. et al.; Merino-Valverde, I.; Richart, L.; Gupta, V.; Li, H.-Y.; Ballasch, I.; Alcazar, N.; Alberch, J.; Canals, J. M.; Abad, M.; Serrano, M.; Klein, R.; Giralt, A.; del Toro, D.: Expansion of the neocortex and protection from neurodegeneration by in vivo transient reprogramming. Cell Stem Cell 31 (12), pp. 1741 - 1759.e8 (2024)

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8.

Journal Article

Peters, C.; He, S.; Fermani, F.; Lim, H.; Mayer, C.; Klein, R.: Transcriptomics reveals amygdala neuron regulation by fasting and ghrelin thereby promoting feeding. Science Advances 9 (21), eadf6521 (2023)

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publisher-version

9.

Journal Article

Voelkl, K.; Gutiérrez-Ángel, S.; Keeling, S.; Koyuncu, S.; da Silva Padilha, M.; Feigenbutz, D.; Arzberger, T.; Vilchez, D.; Klein, R.; Dudanova, I.: Neuroprotective effects of hepatoma-derived growth factor in models of Huntington's disease. Life science alliance 6 (11), e202302018 (2023)

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10.

Journal Article

Chang, S.; Fermani, F.; Lao, C.-L.; Huang, L.; Jakovcevski, M.; Di Giaimo, R.; Gagliardi, M.; Menegaz, D.; Hennrich, A. A.; Ziller, M. et al.; Eder, M.; Klein, R.; Cai, N.; Deussing, J. M.: Tripartite extended amygdala-basal ganglia CRH circuit drives locomotor activation and avoidance behavior. Science Advances 8 (46), eabo1023 (2022)

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11.

Journal Article

Ponserre, M.; Fermani, F.; Gaitanos, L.; Klein, R.: Encoding of environmental cues in central amygdala neurons during foraging. The Journal of Neuroscience 42 (18), pp. 3783 - 3796 (2022)

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12.

Journal Article

Riera Tur, I.; Schäfer, T.; Hornburg, D.; Mishra, A.; da Silva Padilha, M.; Fernández-Mosquera, L.; Feigenbutz, D.; Auer, P.; Mann, M.; Baumeister, W. et al.; Klein, R.; Meissner, F.; Raimundo, N.; Fernandez-Busnadiego, R.; Dudanova, I.: Amyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicity. Life science alliance 5 (3), e202101185 (2022)

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13.

Journal Article

Voelkl, K.; Schulz-Trieglaff, K.; Klein, R.; Dudanova, I.: Distinct histological alterations of cortical interneuron types in mouse models of Huntington’s disease. Frontiers in Neuroscience 16, 1022251 (2022)

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14.

Journal Article

Blumenstock, S.; Schulz-Trieglaff, E. K.; Voelkl, K.; Bolender, A.-L.; Lapios, P.; Lindner, J.; Hipp, M. S.; Hartl, F. U.; Klein, R.; Dudanova, I.: Fluc-EGFP reporter mice reveal differential alterations of neuronal proteostasis in aging and disease. The EMBO Journal 40 (19), e107260 (2021)

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15.

Journal Article

Fleitas, C.; Marfull-Oromi, P.; Chauhan, D.; del Toro, D.; Peguera, B.; Zammou, B.; Rocandio, D.; Klein, R.; Espinet, C.; Egea, J.: FLRT2 and FLRT3 cooperate in maintaining the tangential migratory streams of cortical interneurons during development. The Journal of Neuroscience 41 (35), pp. 7350 - 7362 (2021)

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16.

Journal Article

Haimson, B.; Meir, O.; Sudakevitz-Merzbach, R.; Elberg, G.; Friedrich, S.; Lovell V, P.; Paixao, S.; Klein, R.; Mello V, C.; Klar, A.: Natural loss of function of ephrin-B3 shapes spinal flight circuitry in birds. Science Advances 7 (24), eabg5968 (2021)

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17.

Journal Article

Ruff, T.; Peters, C.; Matsumoto, A.; Ihle, S. J.; Alcala Morales, P. L.; Gaitanos, L.; Yonehara, K.; del Toro, D.; Klein, R.: FLRT3 marks direction-selective retinal ganglion cells that project to the medial terminal nucleus. Frontiers in Molecular Neuroscience 14, 790466 (2021)

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18.

Journal Article

del Toro, D.; Carrasquero-Ordaz, M. A.; Chu, A.; Ruff, T.; Shahin, M.; Jackson, V. A.; Chavent, M.; Berbeira-Santana, M.; Seyit-Bremer, G.; Brignani, S. et al.; Kaufmann, R.; Lowe, E.; Klein, R.; Seiradake, E.: Structural basis of Teneurin-Latrophilin interaction in repulsive guidance of migrating neurons. Cell 180 (2), pp. 323 - 339.e19 (2020)

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supplementary-material

19.

Journal Article

Escalante, A.; Klein, R.: Spinal inhibitory Ptf1a-derived neurons prevent self-generated itch. Cell Reports 33 (8), 108422 (2020)

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20.

Journal Article

Ponserre, M.; Peters, C.; Fermani, F.; Conzelmann, K.-K.; Klein, R.: The insula cortex contacts distinct output streams of the central amygdala. The Journal of Neuroscience 40 (46), pp. 8870 - 8882 (2020)

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21.

Journal Article

Burgold, J.; Schulz-Trieglaff, E. K.; Voelkl, K.; Gutierrez-Angel, S.; Bader, J. M.; Hosp, F.; Mann, M.; Arzberger, T.; Klein, R.; Liebscher, S. et al.; Dudanova, I.: Cortical circuit alterations precede motor impairments in Huntington's disease mice. Scientific Reports 9, 6634 (2019)

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supplementary-material

22.

Journal Article

Gong, J.; Gaitanos, T. N.; Luu, O.; Huang, Y.; Gaitanos, L.; Lindner, J.; Winklbauer, R.; Klein, R.: Gulp1 controls Eph/ephrin trogocytosis and is important for cell rearrangements during development. The Journal of Cell Biology 218 (10), pp. 3455 - 3471 (2019)

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supplementary-material

23.

Journal Article

Paixao, S.; Loschek, L. F.; Gaitanos, L.; Alcala Morales, P. L.; Goulding, M.; Klein, R.: Identification of spinal neurons contributing to the dorsal column projection mediating fine touch and corrective motor movements. Neuron 104 (4), pp. 749 - 764.e6 (2019)

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24.

Journal Article

Klein, R.: Building a better brain: Making new connections. Cell 175 (3), pp. 633 - 634 (2018)

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25.

Journal Article

Bäuerlein, F. J. B.; Saha, I.; Mishra, A.; Kalemanov, M.; Martinez-Sanchez, A.; Klein, R.; Dudanova, I.; Hipp, M. S.; Hartl, F. U.; Baumeister, W. et al.; Fernandez-Busnadiego, R.: In situ architecture and cellular interactions of PolyQ inclusions. Cell 171 (1), pp. 179 - 187 (2017)

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26.

Journal Article

del Toro, D.; Ruff, T.; Cederfjäll, E.; Villalb, A.; Seyit-Bremer, G.; Borrell, V.; Klein, R.: Regulation of cerebral cortex folding by controlling neuronal migration via FLRT adhesion molecules. Cell 169 (4), pp. 621 - 635 (2017)

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27.

Journal Article

Douglass, A. M.; Kucukdereli, H.; Ponserre, M.; Markovic, M.; Gruendemann, J.; Strobel, C.; Alcala Morales, P. L.; Conzelmann, K.-K.; Luethi, A.; Klein, R.: Central amygdala circuits modulate food consumption through a positive-valence mechanism. Nature Neuroscience 20 (10), pp. 1384 - 1394 (2017)

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28.

Journal Article

Hosp, F.; Gutiérrez-Ángel, S.; Schaefer, M. H.; Cox, J.; Meissner, F.; Hipp, M. S.; Hartl, F. U.; Klein, R.; Dudanova, I.; Mann, M.: Spatiotemporal proteomic profiling of Huntington’s disease inclusions reveals widespread loss of protein function. Cell Reports 21 (8), pp. 2291 - 2303 (2017)

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29.

Journal Article

Hunt, S.; Sun, Y.; Kucukdereli, H.; Klein, R.; Sah, P.: Intrinsic circuits in the lateral central amygdala. eNeuro 4 (1), 0367-16.2017 (2017)

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30.

Journal Article

Tai-Nagara, I.; Yoshikawa, Y.; Numata, N.; Ando, T.; Okabe, K.; Sugiura, Y.; Ieda, M.; Takakura, N.; Nakagawa, O.; Zhou, B. et al.; Okabayashi, K.; Suematsu, M.; Kitagawa, Y.; Bastmeyer, M.; Sato, K.; Klein, R.; Navankasattusas, S.; Li, D. Y.; Yamagishi, S.; Kubota, Y.: Placental labyrinth formation in mice requires endothelial FLRT2/UNC5B signaling. Development 144 (13), pp. 2392 - 2401 (2017)

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31.

Journal Article

Gaitanos, T. N.; Körner, J.; Klein, R.: Tiam-Rac signaling mediates trans-endocytosis of ephrin receptor EphB2 and is important for cell repulsion. The Journal of Cell Biology 214 (6), pp. 735 - 752 (2016)

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32.

Journal Article

Gong, J.; Körner, R.; Gaitanos, L.; Klein, R.: Exosomes mediate cell contact-independent ephrin-Eph signaling during axon guidance. The Journal of Cell Biology 214 (1), pp. 35 - 44 (2016)

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33.

Journal Article

Jackson, V. A.; Mehmood, S.; Chavent, M.; Roversi, P.; Carrasquero, M.; del Toro, D.; Seyit-Bremer, G.; Ranaivoson, F. M.; Comoletti, D.; Sansom, M. S. P. et al.; Robinson, C. V.; Klein, R.; Seiradake, E.: Super-complexes of adhesion GPCRs and neural guidance receptors. Nature Communications 7, 11184 (2016)

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34.

Journal Article

Kania, A.; Klein, R.: Mechanisms of ephrin-Eph signalling in development, physiology and disease. Nature Reviews Molecular Cell Biology 17 (4), pp. 240 - 256 (2016)

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35.

Journal Article

Peuckert, C.; Aresh, B.; Holenya, P.; Adams, D.; Sreedharan, S.; Porthin, A.; Andersson, L.; Pettersson, H.; Wolfl, S.; Klein, R. et al.; Oxburgh, L.; Kullander, K.: Multimodal Eph/Ephrin signaling controls several phases of urogenital development. Kidney International 90 (2), pp. 373 - 388 (2016)

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36.

Journal Article

Seiradake, E.; Jones, E. Y.; Klein, R.: Structural perspectives on axon guidance. Annual Review of Cell and Developmental Biology 32, pp. 577 - 608 (2016)

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37.

Journal Article

Fleming, M. S.; Vysochan, A.; Paixao, S.; Niu, J.; Klein, R.; Savitt, J. M.; Luo, W.: Cis and trans RET signaling control the survival and central projection growth of rapidly adapting mechanoreceptors. eLife 4, e06828 (2015)

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38.

Journal Article

Jackson, V. A.; del Toro, D.; Carrasquero, M.; Roversi, P.; Harlos, K.; Klein, R.; Seiradake, E.: Structural basis of latrophilin-FLRT interaction. Structure 23 (4), pp. 774 - 781 (2015)

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39.

Journal Article

Gatto, G.; Morales, D.; Kania, A.; Klein, R.: EphA4 receptor shedding regulates spinal motor axon guidance. Current Biology 24 (20), pp. 2355 - 2365 (2014)

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40.

Journal Article

Klein, P.; Müller-Rischart, A. K.; Motori, E.; Schönbauer, C.; Schnorrer, F.; Winklhofer, K. F.; Klein, R.: Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants. The EMBO Journal 33 (4), pp. 341 - 355 (2014)

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41.

Journal Article

Klein, R.; Kania, A.: Ephrin signalling in the developing nervous system. Current Opinion in Neurobiology 27, pp. 16 - 24 (2014)

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42.

Journal Article

Leyva-Diaz, E.; del Toro, D.; Jose Menal, M.; Cambray, S.; Susin, R.; Tessier-Lavigne, M.; Klein, R.; Egea, J.; Lopez-Bendito, G.: FLRT3 is a Robo1-interacting protein that determines Netrin-1 attraction in developing axons. Current Biology 24 (5), pp. 494 - 508 (2014)

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43.

Journal Article

Mishra, A.; Traut, M. H.; Becker, L.; Klopstock, T.; Stein, V.; Klein, R.: Genetic evidence for the adhesion protein IgSF9/Dasm1 to regulate inhibitory synapse development independent of its intracellular domain. The Journal of Neuroscience 34 (12), pp. 4187 - 4199 (2014)

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44.

Journal Article

Schaupp, A.; Sabet, O.; Dudanova, I.; Ponserre, M.; Bastiaens, P.; Klein, R.: The composition of EphB2 clusters determines the strength in the cellular repulsion response. The Journal of Cell Biology 204 (3), pp. 409 - 422 (2014)

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45.

Journal Article

Seiradake, E.; del Toro, D.; Nagel, D.; Cop, F.; Härtl, R.; Ruff, T.; Seyit-Bremer, G.; Harlos, K.; Border, E. C.; Acker-Palmer, A. et al.; Jones, E. Y.; Klein, R.: FLRT structure: Balancing repulsion and cell adhesion in cortical and vascular development. Neuron 84 (2), pp. 370 - 385 (2014)

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46.

Journal Article

Serradj, N.; Paixao, S.; Sobocki, T.; Feinberg, M.; Klein, R.; Kullander, K.; Martin, J. H.: EphA4-mediated ipsilateral corticospinal tract misprojections are necessary for bilateral voluntary movements but not bilateral stereotypic locomotion. The Journal of Neuroscience 34 (15), pp. 5211 - 5221 (2014)

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47.

Journal Article

Dimidschstein, J.; Passante, L.; Dufour, A.; van den Ameele, J.; Tiberi, L.; Hrechdakian, T.; Adams, R.; Klein, R.; Lie, D. C.; Jossin, Y. et al.; Vanderhaeghen, P.: Ephrin-B1 controls the columnar distribution of cortical pyramidal neurons by restricting their tangential migration. Neuron 79 (6), pp. 1123 - 1135 (2013)

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48.

Journal Article

Dudanova, I.; Klein, R.: Integration of guidance cues: Parallel signaling and crosstalk. Trends in Neurosciences 36 (5), pp. 295 - 304 (2013)

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49.

Journal Article

Gatto, G.; Dudanova, I.; Suetterlin, P.; Davies, A. M.; Drescher, U.; Bixby, J. L.; Klein, R.: Protein tyrosine phosphatase receptor type O inhibits trigeminal axon growth and rranching by repressing TrkB and ret signaling. The Journal of Neuroscience 33 (12), pp. 5399 - 5410 (2013)

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50.

Journal Article

Paixao, S.; Balijepalli, A.; Serradj, N.; Niu, J.; Luo, W.; Martin, J. H.; Klein, R.: EphrinB3/EphA4-mediated guidance of ascending and descending spinal tracts. Neuron 80 (6), pp. 1407 - 1420 (2013)

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