Max Planck Institute for Biological Intelligence

Publications of Dieter E. Jenne

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Journal Article (82)

1.

Journal Article

Casal Moura, M.; Thompson, G. E.; Nelson, D. R.; Fussner, L. A.; Hummel, A. M.; Jenne, D. E.; Emerling, D.; Fervenza, F. C.; Kallenberg, C. G. M.; Langford, C. A. et al.; McCune, W. J.; Merkel, P. A.; Monach, P. A.; Seo, P.; Spiera, R. F.; St. Clair, E. W.; Ytterberg, S. R.; Stone, J. H.; Robinson, W. H.; Specks, U.: Activation of a latent epitope causing differential binding of anti-neutrophil cytoplasmic antibodies to proteinase 3. Arthritis and Rheumatology 75 (5), pp. 748 - 759 (2023)

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2.

Journal Article

Guarino, C.; Seren, S.; Lemoine, R.; Hummel, A. M.; Margotin, J.-E.; El-Benna, J.; Hoarau, C.; Specks, U.; Jenne, D. E.; Korkmaz, B.: Constitutive and induced forms of membrane-bound proteinase 3 interact with antineutrophil cytoplasmic antibodies and promote immune activation of neutrophils. The Journal of Biological Chemistry 299 (4), 103072 (2023)

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3.

Journal Article

Janakiraman, M.; Leliavski, A.; Varadarajulu, J.; Jenne, D. E.; Krishnamoorthy, G.: An engineered Fc fusion protein that targets antigen-specific T cells and autoantibodies mitigates autoimmune disease. Journal of Neuroinflammation 20, 291 (2023)

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4.

Journal Article

Spella, M.; Ntaliarda, G.; Skiadas, G.; Lamort, A.-S.; Vreka, M.; Marazioti, A.; Lilis, I.; Bouloukou, E.; Giotopoulou, G. A.; Pepe, M. A. A. et al.; Weiss, S. A. I.; Petrera, A.; Hauck, S. M.; Koch, I.; Lindner, M.; Hatz, R. A.; Behr, J.; Arendt, K. A. M.; Giopanou, I.; Brunn, D.; Savai, R.; Jenne, D. E.; de Chateau, M.; Yull, F. E.; Blackwell, T. S.; Stathopoulos, G. T.: Non-oncogene addiction of KRAS-mutant cancers to IL-1beta via versican and mononuclear IKKbeta. Cancers / Molecular Diversity Preservation International (MDPI) 15 (6), 1866 (2023)

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5.

Journal Article

Ebert, M.; Jerke, U.; Eulenberg-Gustavus, C.; Kling, L.; Jenne, D. E.; Kirchner, M.; Mertins, P.; Bieringer, M.; Elitok, S.; Eckardt, K.-U. et al.; Schreiber, A.; Salama, A. D.; Kettritz, R.: Protective alpha1-antitrypsin effects in autoimmune vasculitis are compromised by methionine oxidation. The Journal of Clinical Investigation 132 (23), e160089 (2022)

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6.

Journal Article

Kessler, N.; Viehmann, S. F.; Krollmann, C.; Mai, K.; Kirschner, K. M.; Luksch, H.; Kotagiri, P.; Böhner, A. M. C.; Huugen, D.; de Oliveira Mann, C. C. et al.; Otten, S.; Weiss, S. A. I.; Zillinger, T.; Dobrikova, K.; Jenne, D. E.; Behrendt, R.; Ablasser, A.; Bartok, E.; Hartmann, G.; Hopfner, K.-P.; Lyons, P. A.; Boor, P.; Rösen-Wolff, A.; Teichmann, L. L.; Heeringa, P.; Kurts, C.; Garbi, N.: Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing. The Journal of experimental medicine 219 (10), e20220759 (2022)

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7.

Journal Article

Morrone, C.; Smirnova, N. F.; Jeridi, A.; Kneidinger, N.; Hollauer, C.; Schupp, J. C.; Kaminski, N.; Jenne, D. E.; Eickelberg, O.; Yildirim, A. O.: Cathepsin B promotes collagen biosynthesis, which drives bronchiolitis obliterans syndrome. European Respiratory Journal 57 (5), 2001416 (2021)

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8.

Journal Article

Schoeps, B.; Eckfeld, C.; Prokopchuk, O.; Boettcher, J.; Haeussler, D.; Steiger, K.; Demir, I. E.; Knolle, P.; Soehnlein, O.; Jenne, D. E. et al.; Hermann, C. D.; Krueger, A.: TIMP1 triggers neutrophil extracellular trap formation in pancreatic cancer. Cancer Research 81 (13), pp. 3568 - 3579 (2021)

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9.

Journal Article

Seren, S.; Derian, L.; Keles, I.; Guillon, A.; Lesner, A.; Gonzalez, L.; Baranek, T.; Si-Tahar, M.; Marchand-Adam, S.; Jenne, D. E. et al.; Paget, C.; Jouan, Y.; Korkmaz, B.: Proteinase release from activated neutrophils in mechanically ventilated patients with non-COVID-19 and COVID-19 pneumonia. European Respiratory Journal 57 (4), 2003755 (2021)

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10.

Journal Article

Korkmaz, B.; Lesner, A.; Marchand-Adam, S.; Moss, C.; Jenne, D. E.: Lung protection by cathepsin C inhibition: A new hope for COVID-19 and ARDS? Journal of Medicinal Chemistry 63 (22), pp. 13258 - 13265 (2020)

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11.

Journal Article

Fernandez, I. M.; Macrini, C.; Krumbholz, M.; Hensbergen, P. J.; Ederveen, A. L. H.; Winklmeier, S.; Vural, A.; Kurne, A.; Jenne, D. E.; Kamp, F. et al.; Gerdes, L. A.; Hohlfeld, R.; Wuhrer, M.; Kümpfel, T.; Meinl, E.: The glycosylation site of myelin oligodendrocyte glycoprotein affects autoantibody recognition in a large proportion of patients. Frontiers in immunology 10, 1189 (2019)

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12.

Journal Article

Korkmaz, B.; Lesner, A.; Wysocka, M.; Gieldon, A.; Hakansson, M.; Gauthier, F.; Logan, D. T.; Jenne, D. E.; Lauritzen, C.; Pedersen, J.: Structure-based design and in vivo anti-arthritic activity evaluation of a potent dipeptidyl cyclopropyl nitrile inhibitor of cathepsin C. Biochemical Pharmacology 164, pp. 349 - 367 (2019)

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13.

Journal Article

Lamort, A.-S.; Hamon, Y.; Czaplewski, C.; Gieldon, A.; Seren, S.; Coquet, L.; Lecaille, F.; Lesner, A.; Lalmanach, G.; Gauthier, F. et al.; Jenne, D. E.; Korkmaz, B.: Processing and maturation of cathepsin C zymogen: A biochemical and molecular modeling analysis. International Journal of Molecular Sciences 20 (19), 4747 (2019)

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14.

Journal Article

Rehm, S. R. T.; Smirnova, N. F.; Morrone, C.; Goetzfried, J.; Feuchtinger, A.; Pedersen, J.; Korkmaz, B.; Yildirim, A. O.; Jenne, D. E.: Premedication with a cathepsin C inhibitor alleviates early primary graft dysfunction in mouse recipients after lung transplantation. Scientific Reports 9, 9925 (2019)

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15.

Journal Article

Goetzfried, J.; Smirnova, N. F.; Morrone, C.; Korkmaz, B.; Yildirim, A. O.; Eickelberg, O.; Jenne, D. E.: Preservation with α1-antitrypsin improves primary graft function of murine lung transplants. The Journal of Heart and Lung Transplantation 37 (8), pp. 1021 - 1028 (2018)

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publisher-version

16.

Journal Article

Guarino, C.; Gruba, N.; Grzywa, R.; Dyguda-Kazimierowicz, E.; Hamon, Y.; Legowska, M.; Skorenski, M.; Dallet-Choisy, S.; Marchand-Adam, S.; Kellenberger, C. et al.; Jenne, D. E.; Sienczyk, M.; Lesner, A.; Gauthier, F.; Korkmaz, B.: Exploiting the S4-S5 specificity of human neutrophil proteinase 3 to improve the potency of deptidyl Di(chlorophenyl)-phosphonate ester inhibitors: A kinetic and molecular modeling analysis. Journal of Medicinal Chemistry 61 (5), pp. 1858 - 1870 (2018)

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17.

Journal Article

Seren, S.; Abouzaid, M. R.; Eulenberg-Gustavus, C.; Hirschfeld, J.; Soliman, H. N.; Jerke, U.; N'Guessan, K.; Dallet-Choisy, S.; Lesner, A.; Lauritzen, C. et al.; Schacher, B.; Eickholz, P.; Nagy, N.; Szell, M.; Croix, C.; Viaud-Massuard, M.-C.; Aldosari, A. A. F.; Ragunatha, S.; Mostafa, M. I.; Giampieri, F.; Battino, M.; Cornillier, H.; Lorette, G.; Stephan, J.-L.; Goizet, C.; Pedersen, J.; Gauthier, F.; Jenne, D. E.; Marchand-Adam, S.; Chapple, I. L.; Kettritz, R.; Korkmaz, B.: Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis. The Journal of Biological Chemistry 293 (32), pp. 12415 - 12428 (2018)

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publisher-version

18.

Journal Article

Spadaro, M.; Winklmeier, S.; Beltran, E.; Macrini, C.; Hoeftberger, R.; Schuh, E.; Thaler, F. S.; Gerdes, L. A.; Laurent, S.; Gerhards, R. et al.; Braendle, S.; Dornmair, K.; Breithaupt, C.; Krumbholz, M.; Moser, M.; Krishnamoorthy, G.; Kamp, F.; Jenne, D. E.; Hohlfeld, R.; Kuempfel, T.; Lassmann, H.; Kawakami, N.; Meinl, E.: Pathogenicity of human antibodies against myelin oligodendrocyte glycoprotein. Annals of Neurology 84 (2), pp. 315 - 328 (2018)

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19.

Journal Article

Guarino, C.; Hamon, Y.; Croix, C.; Lamort, A.-S.; Dallet-Choisy, S.; Marchand-Adam, S.; Lesner, A.; Baranek, T.; Viaud-Massuard, M.-C.; Lauritzen, C. et al.; Pedersen, J.; Heuze-Vourc'h, N.; Si-Tahar, M.; Firatli, E.; Jenne, D. E.; Gauthier, F.; Horwitz, M. S.; Borregaard, N.; Korkmaz, B.: Prolonged pharmacological inhibition of cathepsin C results in elimination of neutrophil serine proteases. Biochemical Pharmacology 131, pp. 52 - 67 (2017)

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20.

Journal Article

Dau, T.; Edeleva, E. V.; Seidel, S. A. I.; Stockley, R. A.; Braun, D.; Jenne, D. E.: Quantitative analysis of protease recognition by inhibitors in plasma using microscale thermophoresis. Scientific Reports 6, 35413 (2016)

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publisher-version

supplementary-material

21.

Journal Article

Hamon, Y.; Legowska, M.; Fergelot, P.; Dallet-Choisy, S.; Newell, L.; Vanderlynden, L.; Valeshabad, A. K.; Acrich, K.; Kord, H.; Charalampos, T. et al.; Morice-Picard, F.; Surplice, I.; Zoidakis, J.; David, K.; Vlahou, A.; Ragunatha, S.; Nagy, N.; Farkas, K.; Szell, M.; Goizet, C.; Schacher, B.; Battino, M.; Aldosari, A. A. F.; Wang, X.; Liu, Y.; Marchand-Adam, S.; Lesner, A.; Kara, E.; Korkmaz-Icoez, S.; Moss, C.; Eickholz, P.; Taieb, A.; Kavukcu, S.; Jenne, D. E.; Gauthier, F.; Korkmaz, B.: Analysis of urinary cathepsin C for diagnosing Papillon-Lefevre syndrome. The FEBS Journal 283 (3), pp. 498 - 509 (2016)

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22.

Journal Article

Hamon, Y.; Legowska, M.; Herve, V.; Dallet-Choisy, S.; Marchand-Adam, S.; Vanderlynden, L.; Demonte, M.; Williams, R.; Scott, C. J.; Si-Tahar, M. et al.; Heuze-Vourc'h, N.; Lalmanach, G.; Jenne, D. E.; Lesner, A.; Gauthier, F.; Korkmaz, B.: Neutrophilic cathepsin C is maturated by a multistep proteolytic process and secreted by activated cells during inflammatory lung diseases. The Journal of Biological Chemistry 291 (16), pp. 8486 - 8499 (2016)

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23.

Journal Article

Korkmaz, B.; Lesner, A.; Guarino, C.; Wysocka, M.; Kellenberger, C.; Watier, H.; Specks, U.; Gauthier, F.; Jenne, D. E.: Inhibitors and antibody fragments as potential anti-inflammatory therapeutics targeting neutrophil proteinase 3 in human disease. Pharmacological Reviews 68 (3), pp. 603 - 630 (2016)

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24.

Journal Article

Dau, T.; Sarker, R. S. J.; Yildirim, A. O.; Eickelberg, O.; Jenne, D. E.: Autoprocessing of neutrophil elastase near its active site reduces the efficiency of natural and synthetic elastase inhibitors. Nature Communications 6, 6722 (2015)

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25.

Journal Article

Hinkofer, L. C.; Hummel, A. M.; Stone, J. H.; Hoffman, G. S.; Merkel, P. A.; Spiera, E. R. F.; Clair, W. S.; McCune, J. W.; Davis, J. C.; Specks, U. et al.; Jenne, D. E.: Allosteric modulation of proteinase 3 activity by anti-neutrophil cytoplasmic antibodies in granulomatosis with polyangiitis. Journal of Autoimmunity 59, pp. 43 - 52 (2015)

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26.

Journal Article

Laurent, S. A.; Hoffmann, F. S.; Kuhn, P.-H.; Cheng, Q.; Chu, Y.; Schmidt-Supprian, M.; Hauck, S. M.; Schuh, E.; Krumbholz, M.; Rübsamen, H. et al.; Wanngren, J.; Khademi, M.; Olsson, T.; Alexander, T.; Hiepe, F.; Pfister, H.-W.; Weber, F.; Jenne, D. E.; Wekerle, H.; Hohlfeld, R.; Lichtenthaler, S. F.; Meinl, E.: γ-secretase directly sheds the survival receptor BCMA from plasma cells. Nature Communications 6, 7333 (2015)

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27.

Journal Article

Guarino, C.; Legowska, M.; Epinette, C.; Kellenberger, C.; Dallet-Choisy, S.; Sienczyk, M.; Gabant, G.; Cadene, M.; Zoidakis, J.; Vlahou, A. et al.; Wysocka, M.; Marchand-Adam, S.; Jenne, D. E.; Lesner, A.; Gauthier, F.; Korkmaz, B.: New selective peptidyl Di(chlorophenyl) phosphonate esters for visualizing and blocking neutrophil proteinase 3 in human diseases. The Journal of Biological Chemistry 289 (46), pp. 31777 - 31791 (2014)

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28.

Journal Article

Guyot, N.; Wartelle, J.; Malleret, L.; Todorov, A. A.; Devouassoux, G.; Pacheco, Y.; Jenne, D. E.; Belaaouaj, A.: Unopposed cathepsin G, neutrophil elastase, and proteinase 3 cause severe lung damage and emphysema. American Journal of Pathology 184 (8), pp. 2197 - 2210 (2014)

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29.

Journal Article

Jenne, D. E.: Off-target rewards of augmentation therapy with α1-antitrypsin. American Journal of Respiratory and Critical Care Medicine 190 (11), pp. 1203 - 1204 (2014)

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30.

Journal Article

Hedberg, C.; Melberg, A.; Kuhl, A.; Jenne, D. E.; Oldfors, A.: Functional characterization of desmin mutant p.P419S Reply [Letter]. European journal of human genetics 21 (6), p. 590 - 590 (2013)

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31.

Journal Article

Hinkofer, L. C.; Seidel, S. A. I.; Korkmaz, B.; Silva, F.; Hummel, A. M.; Braun, D.; Jenne, D. E.; Specks, U.: A monoclonal antibody (MCPR3-7) interfering with the activity of proteinase 3 by an allosteric mechanism. The Journal of Biological Chemistry 288 (37), pp. 26635 - 26648 (2013)

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32.

Journal Article

Mayer, M. C.; Breithaupt, C.; Reindl, M.; Schanda, K.; Rostasy, K.; Berger, T.; Dale, R. C.; Brilot, F.; Olsson, T.; Jenne, D. E. et al.; Proebstel, A.-K.; Dornmair, K.; Wekerle, H.; Hohlfeld, R.; Banwell, B.; Bar-Or, A.; Meinl, E.: Distinction and temporal stability of conformational epitopes on myelin oligodendrocyte glycoprotein recognized by patients with different inflammatory central nervous system diseases. Journal of Immunology 191 (7), pp. 3594 - 3604 (2013)

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33.

Journal Article

Molnarfi, N.; Schulze-Topphoff, U.; Weber, M. S.; Patarroyo, J. C.; Prod'homme, T.; Varrin-Doyer, M.; Shetty, A.; Linington, C.; Slavin, A. J.; Hidalgo, J. et al.; Jenne, D. E.; Wekerle, H.; Sobel, R. A.; Bernard, C. C. A.; Shlomchik, M. J.; Zamvil, S. S.: MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies. Journal of Experimental Medicine 210 (13), pp. 2921 - 2937 (2013)

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34.

Journal Article

O'Donoghue, A. J.; Jin, Y.; Knudsen, G. M.; Perera, N. C.; Jenne, D. E.; Murphy, J. E.; Craik, C. S.; Hermiston, T. W.: Global substrate profiling of proteases in human neutrophil extracellular traps reveals consensus motif predominantly contributed by elastase. PLoS One 8 (9), e75141 (2013)

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35.

Journal Article

Perera, N. C.; Wiesmueller, K.-H.; Larsen, M. T.; Schacher, B.; Eickholz, P.; Borregaard, N.; Jenne, D. E.: NSP4 is stored in azurophil granules and released by activated neutrophils as active endoprotease with restricted specificity. Journal of Immunology 191 (5), pp. 2700 - 2707 (2013)

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36.

Journal Article

Hedberg, C.; Melberg, A.; Kuhl, A.; Jenne, D. E.; Oldfors, A.: Autosomal dominant myofibrillar myopathy with arrhythmogenic right ventricular cardiomyopathy 7 is caused by a DES mutation. European journal of human genetics 20 (9), pp. 984 - 985 (2012)

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37.

Journal Article

Lippok, S.; Seidel, S. A. I.; Duhr, S.; Uhland, K.; Holthoff, H.-P.; Jenne, D. E.; Braun, D.: Direct detection of antibody concentration and affinity in human serum using microscale thermophoresis. Analytical Chemistry 84 (8), pp. 3523 - 3530 (2012)

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38.

Journal Article

Mankan, A. K.; Dau, T.; Jenne, D. E.; Hornung, V.: The NLRP3/ASC/Caspase-1 axis regulates IL-1 ss processing in neutrophils. European Journal of Immunology 42 (3), pp. 710 - 715 (2012)

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39.

Journal Article

Perera, N. C.; Jenne, D. E.: Perspectives and potential roles for the newly discovered NSP4 in the immune system. Expert Review of Clinical Immunology 8 (6), pp. 501 - 503 (2012)

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40.

Journal Article

Perera, N. C.; Schilling, O.; Kittel, H.; Back, W.; Kremmer, E.; Jenne, D. E.: NSP4, an elastase-related protease in human neutrophils with arginine specificity. Proceedings of the National Academy of Sciences of the United States of America 109 (16), pp. 6229 - 6234 (2012)

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41.

Journal Article

Croker, B. A.; Lewis, R. S.; Babon, J. J.; Mintern, J. D.; Jenne, D. E.; Metcalf, D.; Zhang, J. G.; Cengia, L. H.; O'Donnell, J. A.; Roberts, A. W.: Neutrophils require SHP1 to regulate IL-1β production and prevent inflammatory skin disease. Journal of Immunology 186 (2), pp. 1131 - 1139 (2011)

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42.

Journal Article

Kessenbrock, K.; Dau, T.; Jenne, D. E.: Tailor-made inflammation: How neutrophil serine proteases modulate the inflammatory response. Journal of Molecular Medicine 89 (1), pp. 23 - 28 (2011)

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43.

Journal Article

Motta, J. P.; Magne, L.; Descamps, D.; Rolland, C.; Squarzoni-Dale, C.; Rousset, P.; Martin, L.; Cenac, N.; Balloy, V.; Huerre, M. et al.; Frohlich, L. F.; Jenne, D. E.; Wartelle, J.; Belaaouaj, A.; Mas, E.; Vinel, J. P.; Alric, L.; Chignard, M.; Vergnolle, N.; Sallenave, J. M.: Modifying the protease, antiprotease pattern by elafin overexpression protects mice from colitis. Gastroenterology 140 (4), pp. 1272 - 1282 (2011)

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44.

Journal Article

Pröbstel, A.-K.; Dornmair, K.; Bittner, R.; Sperl, P.; Jenne, D. E.; Magalhaes, S.; Villalobos, A.; Breithaupt, C.; Weissert, R.; Jacob, U. et al.; Krumbholz, M.; Kuempfel, T.; Blaschek, A.; Stark, W.; Gaertner, J.; Pohl, D.; Rostasy, K.; Weber, F.; Forne, I.; Khademi, M.; Olsson, T.; Brilot, F.; Tantsis, E.; Dale, R. C.; Wekerle, H.; Hohlfeld, R.; Banwell, B.; Bar-Or, A.; Meinl, E.; Derfuss, T.: Antibodies to MOG are transient in childhood acute disseminated encephalomyelitis. Neurology 77 (6), pp. 580 - 588 (2011)

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45.

Journal Article

Korkmaz, B.; Horwitz, M. S.; Jenne, D. E.; Gauthier, F.: Neutrophil Elastase, Proteinase 3, and Cathepsin G as Therapeutic Targets in Human Diseases. Pharmacological Reviews 62 (4), pp. 726 - 759 (2010)

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46.

Journal Article

Kuhl, A.; Korkmaz, B.; Utecht, B.; Kniepert, A.; Schonermarck, U.; Specks, U.; Jenne, D. E.: Mapping of Conformational Epitopes on Human Proteinase 3, the Autoantigen of Wegener's Granulomatosis. Journal of Immunology 185 (1), pp. 387 - 399 (2010)

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47.

Journal Article

Kurschus, F. C.; Jenne, D. E.: Delivery and therapeutic potential of human granzyme B. Immunological Reviews 235, pp. 159 - 171 (2010)

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48.

Journal Article

Silva, F.; Hummel, A. M.; Jenne, D. E.; Specks, U.: Discrimination and variable impact of ANCA binding to different surface epitopes on proteinase 3, the Wegener's autoantigen. Journal of Autoimmunity 35 (4), pp. 299 - 308 (2010)

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49.

Journal Article

Kessenbrock, K.; Krumbholz, M.; Schönermarck, U.; Back, W.; Gross, W. L.; Werb, Z.; Gröne, H. J.; Brinkmann, V.; Jenne, D. E.: Netting neutrophils in autoimmune small-vessel vasculitis. Nature Medicine 15 (6), pp. 623 - 625 (2009)

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50.

Journal Article

Kurschus, F. C.; Pal, P. P.; Bäumler, P.; Jenne, D. E.; Wiltschi, B.; Budisa, N.: Gold Fluorescent Annexin A5 as a Novel Apoptosis Detection Tool. Cytometry Part A 75A (7), pp. 626 - 633 (2009)

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