Publications of H. Wekerle

Journal Article (103)

2010
Journal Article
Wekerle, H.; Hohlfeld, R.: Zero Tolerance (to Acetylcholine Receptor) and Ways to Overcome It. Annals of Neurology 67 (4), pp. 422 - 424 (2010)
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Wekerle, H.; Sun, D. M.: Fragile privileges: Autoimmunity in brain and eye. Acta Pharmacologica Sinica 31 (9), pp. 1141 - 1148 (2010)
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2009
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Bartholomäus, I.; Kawakami, N.; Odoardi, F.; Schläger, C.; Miljkovic, D.; Ellwart, J. W.; Klinkert, W. E. F.; Flügel-Koch, C.; Issekutz, T. B.; Wekerle, H. et al.; Flügel, A.: Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions. Nature 462 (7269), pp. 94 - 98 (2009)
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Bauer, M.; Brakebusch, C.; Coisne, C.; Sixt, M.; Wekerle, H.; Engelhardt, B.; Fässler, R.: β1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity. Proceedings of the National Academy of Sciences of the United States of America 106 (6), pp. 1920 - 1925 (2009)
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Derfuss, T.; Parikh, K.; Velhin, S.; Braun, M.; Mathey, E.; Krumbholz, M.; Kümpfel, T.; Moldenhauer, A.; Rader, C.; Sonderegger, P. et al.; Pöllmann, W.; Tiefenthaller, C.; Bauer, J.; Lassmann, H.; Wekerle, H.; Karagogeos, D.; Hohlfeld, R.; Linington, C.; Meinl, E.: Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals. Proceedings of the National Academy of Sciences of the United States of America 106 (20), pp. 8302 - 8307 (2009)
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Junker, A.; Krumbholz, M.; Eisele, S.; Mohan, H.; Augstein, F.; Bittner, R.; Lassmann, H.; Wekerle, H.; Hohlfeld, R.; Meinl, E.: MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47. Brain 132, pp. 3342 - 3352 (2009)
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Krishnamoorthy, G.; Saxena, A.; Mars, L. T.; Domingues, H. S.; Ben-Nun, A.; Lassmann, H.; Dornmair, K.; Mentele, R.; Kurschus, F. C.; Liblau, R. S. et al.; Wekerle, H.: Myelin-specific T cells also recognize neuronal autoantigen in a transgenic mouse model of multiple sclerosis. Nature Medicine 15 (6), pp. 626 - 632 (2009)
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Krishnamoorthy, G.; Wekerle, H.: EAE: An immunologist's magic eye. European Journal of Immunology 39 (8), pp. 2031 - 2035 (2009)
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Pöllinger, B.; Krishnamoorthy, G.; Berer, K.; Lassmann, H.; Bösl, M. R.; Dunn, R.; Domingues, H. S.; Holz, A.; Kurschus, F. C.; Wekerle, H.: Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells. Journal of Experimental Medicine 206 (6), pp. 1303 - 1316 (2009)
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2008
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Hohlfeld, R.; Wekerle, H.: Reflections on the "intrathymic pathogenesis" of myasthenia gravis. Journal of Neuroimmunology 201-202, pp. 21 - 27 (2008)
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Obermeier, B.; Malotka, J.; Kellermann, J.; Kümpfel, T.; Wekerle, H.; Lottspeich, F.; Mentele, R.; Hohlfeld, R.; Dornmair, K.: Matching of oligoclonal immunoglobulin transcriptomes and proteomes of cerebrospinal fluid in multiple sclerosis. Nature Medicine 14 (6), pp. 688 - 693 (2008)
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2007
Journal Article
Grundtner, R.; Dornmair, K.; Dahm, R.; Flügel, A.; Kawakami, N.; Zeitelhofer, M.; Schoderboeck, L.; Nosov, M.; Selzer, E.; Willheim, M. et al.; Kiebler, M.; Wekerle, H.; Lassmann, H.; Bradl, M.: Transition from enhanced T cell infiltration to inflammation in the myelin-degenerative central nervous system. Neurobiology of Disease 28 (3), pp. 261 - 275 (2007)
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Junker, A.; Ivanidze, J.; Malotka, J.; Eiglmeier, I.; Lassmann, H.; Wekerle, H.; Meinl, E.; Hohlfeld, R.; Dornmair, K.: Multiple sclerosis: T-cell receptor expression in distinct brain regions. Brain 130, pp. 2789 - 2799 (2007)
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Krishnamoorthy, G.; Holz, A.; Wekerle, H.: Experimental models of spontaneous in the central nervous system. Journal of Molecular Medicine-JMM 85 (11), pp. 1161 - 1173 (2007)
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Odoardi, F.; Kawakami, N.; Klinkert, W. E. F.; Wekerle, H.; Flügel, A.: Blood-borne soluble protein antigen intensifies T cell activation in autoimmune CNS lesions and exacerbates clinical disease. Proceedings of the National Academy of Sciences of the United States of America 104 (47), pp. 18625 - 18630 (2007)
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Odoardi, F.; Kawakami, N.; Li, Z. X.; Cordiglieri, C.; Streyl, K.; Nosov, M.; Klinkert, W. E. F.; Ellwart, J. W.; Bauer, J.; Lassmann, H. et al.; Wekerle, H.; Flügel, A.: Instant effect of soluble antigen on effector T cells in peripheral immune organs during immunotherapy of autoimmune encephalomyelitis. Proceedings of the National Academy of Sciences of the United States of America 104 (3), pp. 920 - 925 (2007)
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Wekerle, H.: L'énigme de l'entrée des lymphocytes T auto-immuns dans les tissus nerveux centraux et de leur attaque contre les structures de myéline. Comptes Rendus Biologies 330 (1), pp. 1 - 12 (2007)
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2006
Journal Article
Hohlfeld, R.; Kerschensteiner, M.; Stadelmann, C.; Lassmann, H.; Wekerle, H.: The neuroprotective effect of inflammation: Implications for the therapy of multiple sclerosis. Neurological Sciences 27, pp. S1 - S7 (2006)
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Krishnamoorthy, G.; Lassmann, H.; Wekerle, H.; Holz, A.: Spontaneous opticospinal encephalomyelitis in a double-transgenic mouse model of autoimmune T cell B cell cooperation. The Journal of Clinical Investigation 116 (9), pp. 2385 - 2392 (2006)
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Journal Article
Seitz, S.; Schneider, C. K.; Malotka, J.; Nong, X.; Engel, A. G.; Wekerle, H.; Hohlfeld, R.; Dornmair, K.: Reconstitution of paired T cell receptor α- and β-chains from microdissected single cells of human inflammatory tissues. Proceedings of the National Academy of Sciences of the United States of America 103 (32), pp. 12057 - 12062 (2006)
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Wekerle, H.; Kurschus, F. C.: Animal models of multiple sclerosis. Drug Discovery Today: Disease Models 3 (4), pp. 359 - 367 (2006)
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Wekerle, H.; Linington, C.: Organ specific autoantigens and the autoreactive T cell repertoire: The case of myelin oligodendrocyte glycoprotein. European Journal of Immunology 36 (3), pp. 512 - 515 (2006)
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2005
Journal Article
Bradl, M.; Bauer, J.; Flügel, A.; Wekerle, H.; Lassmann, H.: Complementary contribution of CD4 and CD8 T lymphocytes to T-cell infiltration of the intact and the degenerative spinal cord. American Journal of Pathology 166 (5), pp. 1441 - 1450 (2005)
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Farina, C.; Weber, M. S.; Meinl, E.; Wekerle, H.; Hohlfeld, R.: Glatiramer acetate in multiple sclerosis: Update on potential mechanisms of action. Lancet Neurology 4 (9), pp. 567 - 575 (2005)
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Hohlfeld, R.; Wekerle, H.: Drug insight: Using monoclonal antibodies to treat multiple sclerosis. Nature Clinical Practice Neurology 1, pp. 34 - 44 (2005)
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Kawakami, N.; Nägerl, U. V.; Odoardi, F.; Bonhoeffer, T.; Wekerle, H.; Flügel, A.: Live imaging of effector cell trafficking and autoantigen recognition within the unfolding autoimmune encephalomyelitis lesion. Journal of Experimental Medicine 201 (11), pp. 1805 - 1814 (2005)
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Kawakami, N.; Odoardi, F.; Ziemssen, T.; Bradl, M.; Ritter, T.; Neuhaus, O.; Lassmann, H.; Wekerle, H.; Flügel, A.: Autoimmune CD4(+) T cell memory: Lifelong persistence of encephalitogenic T cell clones in healthy immune repertoires. Journal of Immunology 175 (1), pp. 69 - 81 (2005)
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Krumbholz, M.; Theil, D.; Derfuss, T.; Rosenwald, A.; Schrader, F.; Monoranu, C. M.; Kalled, S. L.; Hess, D. M.; Serafini, B.; Aloisi, F. et al.; Wekerle, H.; Hohlfeld, R.; Meinl, E.: BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma. Journal of Experimental Medicine 201 (2), pp. 195 - 200 (2005)
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Wekerle, H.: Immune pathogenesis of multiple sclerosis. Neurological Sciences 26 (1), pp. S1 - S2 (2005)
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Wekerle, H.: Planting and pruning in the brain: MHC antigens involved in synaptic plasticity? Proceedings of the National Academy of Sciences of the United States of America 102 (1), pp. 3 - 4 (2005)
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2004
Journal Article
Aboul-Enein, F.; Bauer, J.; Klein, M.; Schubart, A.; Flügel, A.; Ritter, T.; Kawakami, N.; Siedler, F.; Linington, C.; Wekerle, H. et al.; Lassmann, H.; Bradl, M.: Selective and antigen-dependent effects of myelin degeneration on central nervous system inflammation. Journal of Neuropathology and Experimental Neurology 63 (12), pp. 1284 - 1296 (2004)
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Hohlfeld, R.; Wekerle, H.: Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: From pipe dreams to (therapeutic) pipelines. Proceedings of the National Academy of Sciences of the United States of America 101 (Suppl. Suppl. 2), pp. 14599 - 14606 (2004)
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Kawakami, N.; Lassmann, S.; Li, Z. X.; Odoardi, F.; Ritter, T.; Ziemssen, T.; Klinkert, W. E. F.; Ellwart, J. W.; Bradl, M.; Krivacic, K. et al.; Lassmann, H.; Ransohoff, R. M.; Volk, H. D.; Wekerle, H.; Linington, C.; Flügel, A.: The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of autoimmune encephalomyelitis. Journal of Experimental Medicine 199 (2), pp. 185 - 197 (2004)
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Kawakami, N.; Nägerl, U. V.; Wekerle, H.; Flügel, A.: Live-imaging of encephalitogenic T lymphocytes in the living target tissue. Journal of Neuroimmunology 154 (1-2 Sp. Iss. Sp. Iss. SI), p. 224 - 224 (2004)
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Skulina, C.; Schmidt, S.; Dornmair, K.; Babbe, H.; Roers, A.; Rajewsky, K.; Wekerle, H.; Hohlfeld, R.; Goebels, N.: Multiple sclerosis: Brain-infiltrating CD8(+) T cells persist as clonal expansions in the cerebrospinal fluid and blood. Proceedings of the National Academy of Sciences of the United States of America 101 (8), pp. 2428 - 2433 (2004)
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2003
Journal Article
Dornmair, K.; Goebels, N.; Weltzien, H. U.; Wekerle, H.; Hohlfeld, R.: T-cell-mediated autoimmunity - Novel techniques to characterize autoreactive T-cell receptors. American Journal of Pathology 163 (4), pp. 1215 - 1226 (2003)
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Hofbauer, M.; Wiesener, S.; Babbe, H.; Roers, A.; Wekerle, H.; Dornmair, K.; Goebels, N.: Clonal tracking of autoaggressive T cells in polymyositis by combining laser microdissection, single-cell PCR, and CDR3-spectratype analysis. Proceedings of the National Academy of Sciences of the United States of America 100 (7), pp. 4090 - 4095 (2003)
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Kerschensteiner, M.; Stadelmann, C.; Dechant, G.; Wekerle, H.; Hohlfeld, R.: Neurotrophic cross-talk between the nervous and immune systems: Implications for neurological diseases. Annals of Neurology 53 (3), pp. 292 - 304 (2003)
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Wekerle, H.; Hohlfeld, R.: Molecular mimicry in multiple sclerosis. New England Journal of Medicine 349 (2), pp. 185 - 186 (2003)
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2002
Journal Article
Bauer, J.; Bradl, M.; Klein, M.; Leisser, M.; Deckwerth, T. L.; Wekerle, H.; Lassmann, H.: Endoplasmic reticulum stress in PLP-overexpressing transgenic rats: Gray matter oligodendrocytes are more vulnerable than white matter oligodendrocytes. Journal of Neuropathology and Experimental Neurology 61 (1), pp. 12 - 22 (2002)
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Neumann, H.; Schweigreiter, R.; Yamashita, T.; Rosenkranz, K.; Wekerle, H.; Barde, Y. A.: Tumor necrosis factor inhibits neurite outgrowth and branching of hippocampal neurons by a Rho-dependent mechanism. The Journal of Neuroscience 22 (3), pp. 854 - 862 (2002)
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Wekerle, H.: Immune protection of the brain - Efficient and delicate. The Journal of Infectious Diseases 186 (Suppl. 2), pp. S140 - S144 (2002)
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Wekerle, H.: Tackling multiple sclerosis. Nature 420 (6911), pp. 39 - 40 (2002)
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Wiendl, H.; Malotka, J.; Holzwarth, B.; Weltzien, H. U.; Wekerle, H.; Hohlfeld, R.; Dornmair, K.: An autoreactive gamma delta TCR derived from a polymyositis lesion. Journal of Immunology 169 (1), pp. 515 - 521 (2002)
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2001
Journal Article
Flugel, A.; Matsumuro, K.; Neumann, H.; Klinkert, W. E. F.; Birnbacher, R.; Lassmann, H.; Otten, U.; Wekerle, H.: Anti-inflammatory activity of nerve growth factor in experimental autoimmune encephalomyelitis: Inhibition of monocyte transendothelial migration. European Journal of Immunology 31 (1), pp. 11 - 22 (2001)
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Medana, I.; Martinic, M. A.; Wekerle, H.; Neumann, H.: Transection of major histocompatibility complex class I-induced neurites by cytotoxic T lymphocytes. American Journal of Pathology 159 (3), pp. 809 - 815 (2001)
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2000
Journal Article
Hohlfeld, R.; Kerschensteiner, M.; Stadelmann, C.; Lassmann, H.; Wekerle, H.: The neuroprotective effect of inflammation: Implications for the therapy of multiple sclerosis. Journal of Neuroimmunology 107 (2), pp. 161 - 166 (2000)
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1999
Journal Article
Bradl, M.; Bauer, J.; Inomata, T.; Zielasek, J.; Nave, K. A.; Toyka, K.; Lassmann, H.; Wekerle, H.: Transgenic Lewis rats overexpressing the proteolipid protein gene: Myelin degeneration and its effect on T cell-mediated experimental autoimmune encephalomyelitis. Acta Neuropathologica 97 (6), pp. 595 - 606 (1999)
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Kerschensteiner, M.; Gallmeier, E.; Behrens, L.; Vargas-Leal, V.; Misgeld, T.; Klinkert, W. E. F.; Kolbeck, R.; Hoppe, E.; Oropeza-Wekerle, R. L.; Bartke, I. et al.; Stadelmann, C.; Lassmann, H.; Wekerle, H.; Hohlfeld, R.: Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: A neuroprotective role of inflammation? Journal of Experimental Medicine 189 (5), pp. 865 - 870 (1999)
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1998
Journal Article
Bauer, J.; Bradl, M.; Hickey, W. F.; Forss-Petter, S.; Breitschopf, H.; Linington, C.; Wekerle, H.; Lassmann, H.: T-cell apoptosis in inflammatory brain lesions - Destruction of T cells does not depend on antigen recognition. American Journal of Pathology 153 (3), pp. 715 - 724 (1998)
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