Publications of Markus Krumbholz

Colombo, E.; Cordiglieri, C.; Melli, G.; Newcombe, J.; Krumbholz, M.; Parada, L. F.; Medico, E.; Hohlfeld, R.; Meinl, E.; Farina, C.: Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration. Journal of Experimental Medicine 209 (3), pp. 521 - 535 (2012)

Eisele, S.; Krumbholz, M.; Fischer, M.-T.; Mohan, H.; Junker, A.; Arzberger, T.; Hohlfeld, R.; Bradl, M.; Lassmann, H.; Meinl, E.: Prospects of transcript profiling for mRNAs and microRNAs using formalin-fixed and paraffin-embedded dissected autoptic multiple sclerosis lesions. Brain Pathology 22 (5), pp. 607 - 618 (2012)

Eisele, S.; Krumbholz, M.; Fischer, M.-T.; Mohan, H.; Junker, A.; Arzberger, T.; Hohlfeld, R.; Bradl, M.; Lassmann, H.; Meinl, E.: Prospects of transcript profiling for mRNAs and microRNAs using formalin fixed and paraffin embedded dissected autoptic multiple sclerosis lesions. Brain Pathology 22, pp. 607 - 618 (2012)

Krumbholz, M.; Derfuss, T.; Hohlfeld, R.; Meinl, E.: B cells and antibodies in multiple sclerosis pathogenesis and therapy. Nature Reviews Neurology 8 (11), pp. 613 - 623 (2012)

Schankin, C. J.; Reifferscheid, A. K.; Krumbholz, M.; Linn, J.; Rachinger, W.; Langer, S.; Sostak, P.; Arzberger, T.; Kretzschmar, H.; Straube, A.: Headache in patients with pituitary adenoma: Clinical and paraclinical findings. Cephalalgia 32 (16), pp. 1198 - 1207 (2012)

Meinl, E.; Derfuss, T.; Krumbholz, M.; Pröbstel, A. K.; Hohlfeld, R.: Humoral autoimmunity in multiple sclerosis. Journal of the Neurological Sciences 306 (1-2), pp. 180 - 182 (2011)

Pellkofer, H. L.; Krumbholz, M.; Berthele, A.; Hemmer, B.; Gerdes, L. A.; Havla, J.; Bittner, R.; Canis, M.; Meinl, E.; Hohlfeld, R. et al.; Kuempfel, T.: Long-term follow-up of patients with neuromyelitis optica after repeated therapy with rituximab. Neurology 76 (15), pp. 1310 - 1315 (2011)

Pröbstel, A.-K.; Dornmair, K.; Bittner, R.; Sperl, P.; Jenne, D. E.; Magalhaes, S.; Villalobos, A.; Breithaupt, C.; Weissert, R.; Jacob, U. et al.; Krumbholz, M.; Kuempfel, T.; Blaschek, A.; Stark, W.; Gaertner, J.; Pohl, D.; Rostasy, K.; Weber, F.; Forne, I.; Khademi, M.; Olsson, T.; Brilot, F.; Tantsis, E.; Dale, R. C.; Wekerle, H.; Hohlfeld, R.; Banwell, B.; Bar-Or, A.; Meinl, E.; Derfuss, T.: Antibodies to MOG are transient in childhood acute disseminated encephalomyelitis. Neurology 77 (6), pp. 580 - 588 (2011)

Mohan, H.; Krumbholz, M.; Sharma, R.; Eisele, S.; Junker, A.; Sixt, M.; Newcombe, J.; Wekerle, H.; Hohlfeld, R.; Lassmann, H. et al.; Meinl, E.: Extracellular matrix in multiple sclerosis lesions: Fibrillar collagens, biglycan and decorin are upregulated and associated with infiltrating immune cells. Brain Pathology 20 (5), pp. 966 - 975 (2010)

Schankin, C. J.; Krumbholz, M.; Sostak, P.; Reinisch, V. M.; Goldbrunner, R.; Straube, A.: Headache in patients with a meningioma correlates with a bone-invasive growth pattern but not with cytokine expression. Cephalalgia 30 (4), pp. 413 - 424 (2010)

Derfuss, T.; Parikh, K.; Velhin, S.; Braun, M.; Mathey, E.; Krumbholz, M.; Kümpfel, T.; Moldenhauer, A.; Rader, C.; Sonderegger, P. et al.; Pöllmann, W.; Tiefenthaller, C.; Bauer, J.; Lassmann, H.; Wekerle, H.; Karagogeos, D.; Hohlfeld, R.; Linington, C.; Meinl, E.: Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals. Proceedings of the National Academy of Sciences of the United States of America 106 (20), pp. 8302 - 8307 (2009)

Junker, A.; Krumbholz, M.; Eisele, S.; Mohan, H.; Augstein, F.; Bittner, R.; Lassmann, H.; Wekerle, H.; Hohlfeld, R.; Meinl, E.: MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47. Brain 132, pp. 3342 - 3352 (2009)

Kessenbrock, K.; Krumbholz, M.; Schönermarck, U.; Back, W.; Gross, W. L.; Werb, Z.; Gröne, H. J.; Brinkmann, V.; Jenne, D. E.: Netting neutrophils in autoimmune small-vessel vasculitis. Nature Medicine 15 (6), pp. 623 - 625 (2009)

Krumbholz, M.; Faber, H.; Steinmeyer, F.; Hoffmann, L. A.; Kümpfel, T.; Pellkofer, H.; Derfuss, T.; Ionescu, C.; Starck, M.; Hafner, C. et al.; Hohlfeld, R.; Meinl, E.: Interferon-β increases BAFF levels in multiple sclerosis: Implications for B cell autoimmunity. Brain 131, pp. 1455 - 1463 (2008)

Krumbholz, M.; Meinl, I.; Kümpfel, T.; Hohlfeld, R.; Meinl, E.: Natalizumab disproportionately increases circulating pre-B and B cells in multiple sclerosis. Neurology 71 (17), pp. 1350 - 1354 (2008)

Meinl, E.; Krumbholz, M.; Derfuss, T.; Junker, A.; Hohlfeld, R.: Compartmentalization of inflammation in the CNS: A major mechanism driving progressive multiple sclerosis. Journal of Neurological Sciences 274 (1-2), pp. 42 - 44 (2008)

Hoffmann, L. A.; Krumbholz, M.; Faber, H.; Kuempfel, T.; Starck, M.; Pöllmann, W.; Meinl, E.; Hohlfeld, R.: Multiple sclerosis: Relating MxA transcription to anti-interferon-β-neutralizing antibodies. Neurology 68 (12), pp. 958 - 959 (2007)

Krumbholz, M.; Pellkofer, H.; Gold, R.; Hoffmann, L.; Hohlfeld, R.; Kümpfel, T.: Delayed allergic reaction to natalizumab associated with early formation of neutralizing antibodies. Archives of Neurology 64, pp. 1331 - 1333 (2007)

Krumbholz, M.; Theil, D.; Steinmeyer, F.; Cepok, S.; Hemmer, B.; Hofbauer, M.; Farina, C.; Derfuss, T.; Junker, A.; Arzberger, T. et al.; Sinicina, I.; Hartle, C.; Newcombe, J.; Hohlfeld, R.; Meinl, E.: CCL19 is constitutively expressed in the CNS, up-regulated in neuroinflammation, active and also inactive multiple sclerosis lesions. Journal of Neuroimmunology 190 (1-2), pp. 72 - 79 (2007)

Krumbholz, M.; Theil, D.; Cepok, S.; Hemmer, B.; Kivisakk, P.; Ransohoff, R. M.; Hofbauer, M.; Farina, C.; Derfuss, T.; Hartle, C. et al.; Newcombe, J.; Hohlfeld, R.; Meinl, E.: Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment. Brain 129, pp. 200 - 211 (2006)

Meinl, E.; Krumbholz, M.; Hohlfeld, R.: B lineage cells in inflammatory central nervous system - Reply. Annals of Neurology 60 (4), p. 487 - 487 (2006)

Meinl, E.; Krumbholz, M.; Hohlfeld, R.: B lineage cells in the inflammatory central nervous system environment: Migration, maintenance, local antibody production, and therapeutic modulation. Annals of Neurology 59 (6), pp. 880 - 892 (2006)

Farina, C.; Krumbholz, M.; Giese, T.; Hartmann, G.; Aloisi, F.; Meinl, E.: Preferential expression and function of Toll-like receptor 3 in human astrocytes. Journal of Neuroimmunology 159 (1-2), pp. 12 - 19 (2005)

Krumbholz, M.; Specks, U.; Wick, M.; Kalled, S. L.; Jenne, D. E.; Meinl, E.: BAFF is elevated in serum of patients with Wegener's granulomatosis. Journal of Autoimmunity 25 (4), pp. 298 - 302 (2005)

Krumbholz, M.; Theil, D.; Derfuss, T.; Rosenwald, A.; Schrader, F.; Monoranu, C. M.; Kalled, S. L.; Hess, D. M.; Serafini, B.; Aloisi, F. et al.; Wekerle, H.; Hohlfeld, R.; Meinl, E.: BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma. Journal of Experimental Medicine 201 (2), pp. 195 - 200 (2005)

Vargas-Leal, V.; Bruno, R.; Derfuss, T.; Krumbholz, M.; Hohlfeld, R.; Meinl, E.: Expression and function of glial cell line-derived neurotrophic factor (GDNF) family ligands and their receptors on human immune cells. Journal of Immunology 175 (4), pp. 2301 - 2308 (2005)