Publikationen der Abteilung Moleküle - Signale - Entwicklung

Zeitschriftenartikel (160)

2022
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Blumenstock, S.; Dudanova, I.: Balancing neuronal circuits. Science 377 (6613), S. 1383 - 1384 (2022)
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Ponserre, M.; Fermani, F.; Gaitanos, L.; Klein, R.: Encoding of environmental cues in central amygdala neurons during foraging. The Journal of Neuroscience 42 (18), S. 3783 - 3796 (2022)
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Riera Tur, I.; Schäfer, T.; Hornburg, D.; Mishra, A.; da Silva Padilha, M.; Fernández-Mosquera, L.; Feigenbutz, D.; Auer, P.; Mann, M.; Baumeister, W. et al.; Klein, R.; Meissner, F.; Raimundo, N.; Fernandez-Busnadiego, R.; Dudanova, I.: Amyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicity. Life science alliance 5 (3), e202101185 (2022)
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Saha, I.; Yuste-Checa, P.; da Silva Padilha, M.; Guo, Q.; Körner, R.; Holthusen, H.; Trinkaus, V. A.; Dudanova, I.; Fernández-Busnadiego, R.; Baumeister, W. et al.; Sanders, D. W.; Gautam, S.; Diamond, M. I.; Hartl, F. U.; Hipp, M. S.: The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds. BioRxiv (2022)
2021
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Blumenstock, S.; Schulz-Trieglaff, E. K.; Voelkl, K.; Bolender, A.-L.; Lapios, P.; Lindner, J.; Hipp, M. S.; Hartl, F. U.; Klein, R.; Dudanova, I.: Fluc-EGFP reporter mice reveal differential alterations of neuronal proteostasis in aging and disease. The EMBO Journal 40 (19), e107260 (2021)
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Fleitas, C.; Marfull-Oromi, P.; Chauhan, D.; del Toro, D.; Peguera, B.; Zammou, B.; Rocandio, D.; Klein, R.; Espinet, C.; Egea, J.: FLRT2 and FLRT3 cooperate in maintaining the tangential migratory streams of cortical interneurons during development. The Journal of Neuroscience 41 (35), S. 7350 - 7362 (2021)
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Haimson, B.; Meir, O.; Sudakevitz-Merzbach, R.; Elberg, G.; Friedrich, S.; Lovell V, P.; Paixao, S.; Klein, R.; Mello V, C.; Klar, A.: Natural loss of function of ephrin-B3 shapes spinal flight circuitry in birds. Science Advances 7 (24), eabg5968 (2021)
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Klein, R.; Pasterkamp, R. J.: Recent advances in inter-cellular interactions during neural circuit assembly. Current Opinion in Neurobiology 69, S. 25 - 32 (2021)
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Robinson, R. A.; Griffiths, S. C.; van de Haar, L. L.; Malinauskas, T.; van Battum, E. Y.; Zelina, P.; Schwab, R. A.; Karia, D.; Malinauskaite, L.; Brignani, S. et al.; van den Munkhof, M. H.; Dudukcu, O.; De Ruiter, A. A.; Van den Heuvel, D. M. A.; Bishop, B.; Elegheert, J.; Aricescu, A. R.; Pasterkamp, R. J.; Siebold, C.: Simultaneous binding of guidance cues NET1 and RGM blocks extracellular NEO1 signaling. Cell 184 (8), S. 2103 - 2120.e31 (2021)
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Ruff, T.; Peters, C.; Matsumoto, A.; Ihle, S. J.; Morales, P. A.; Gaitanos, L.; Yonehara, K.; del Toro, D.; Klein, R.: FLRT3 marks direction-selective retinal ganglion cells that project to the medial terminal nucleus. Frontiers in Molecular Neuroscience 14, 790466 (2021)
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Trinkaus, V. A.; Riera Tur, I.; Martinez-Sanchez, A.; Bauerlein, F. J. B.; Guo, Q.; Arzberger, T.; Baumeister, W.; Dudanova, I.; Hipp, M. S.; Hartl, F. U. et al.; Fernandez-Busnadiego, R.: In situ architecture of neuronal alpha-Synuclein inclusions. Nature Communications 12, 2110 (2021)
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Yuste-Checa, P.; Trinkaus, V. A.; Riera Tur, I.; Imamoglu, R.; Schaller, T. F.; Wang, H.; Dudanova, I.; Hipp, M. S.; Bracher, A.; Hartl, F. U.: The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model. Nature Communications 12, 4863 (2021)
2020
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Blumenstock, S.; Dudanova, I.: Cortical and striatal circuits in Huntington's disease. Frontiers in Neuroscience 14, 82 (2020)
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del Toro, D.; Carrasquero-Ordaz, M. A.; Chu, A.; Ruff, T.; Shahin, M.; Jackson, V. A.; Chavent, M.; Berbeira-Santana, M.; Seyit-Bremer, G.; Brignani, S. et al.; Kaufmann, R.; Lowe, E.; Klein, R.; Seiradake, E.: Structural basis of Teneurin-Latrophilin interaction in repulsive guidance of migrating neurons. Cell 180 (2), S. 323 - 339.e19 (2020)
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Escalante, A.; Klein, R.: Spinal inhibitory Ptf1a-derived neurons prevent self-generated itch. Cell Reports 33 (8), 108422 (2020)
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Peters, C.; Bascunan, D.; Burgos, C. F.; Bobadilla, C.; Gonzalez-Sanmiguel, J.; Boopathi, S.; Riffo, N.; Fernandez-Perez, E. J.; Elena Tarnok, M.; Felipe Aguilar, L. et al.; Gonzalez, W.; Aguayo, L. G.: Characterization of a new molecule capable of inhibiting several steps of the amyloid cascade in Alzheimer's disease. Neurobiology of Disease 141, 104938 (2020)
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Ponserre, M.; Peters, C.; Fermani, F.; Conzelmann, K.-K.; Klein, R.: The insula cortex contacts distinct output streams of the central amygdala. The Journal of Neuroscience 40 (46), S. 8870 - 8882 (2020)
2019
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Burgold, J.; Schulz-Trieglaff, E. K.; Voelkl, K.; Gutierrez-Angel, S.; Bader, J. M.; Hosp, F.; Mann, M.; Arzberger, T.; Klein, R.; Liebscher, S. et al.; Dudanova, I.: Cortical circuit alterations precede motor impairments in Huntington's disease mice. Scientific Reports 9, 6634 (2019)
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Cramer, K.; Bolender, A.-L.; Stockmar, I.; Jungmann, R.; Kasper, R.; Shin, J. Y.: Visualization of bacterial protein complexes labeled with fluorescent proteins and nanobody binders for STED microscopy. International Journal of Molecular Sciences 20 (14), 3376 (2019)
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Gong, J.; Gaitanos, T. N.; Luu, O.; Huang, Y.; Gaitanos, L.; Lindner, J.; Winklbauer, R.; Klein, R.: Gulp1 controls Eph/ephrin trogocytosis and is important for cell rearrangements during development. The Journal of Cell Biology 218 (10), S. 3455 - 3471 (2019)
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Paixao, S.; Loschek, L.; Gaitanos, L.; Morales, P. A.; Goulding, M.; Klein, R.: Identification of spinal neurons contributing to the dorsal column projection mediating fine touch and corrective motor movements. Neuron 104 (4), S. 749 - 764.e6 (2019)
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Stuerner, T.; Tatarnikova, A.; Mueller, J.; Schaffran, B.; Cuntz, H.; Zhang, Y.; Nemethova, M.; Bogdan, S.; Small, V.; Tavosanis, G.: Transient localization of the Arp2/3 complex initiates neuronal dendrite branching in vivo. Development 146 (7), dev171397 (2019)
2018
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Klein, R.: Building a better brain: Making new connections. Cell 175 (3), S. 633 - 634 (2018)
2017
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Bäuerlein, F. J. B.; Saha, I.; Mishra, A.; Kalemanov, M.; Martinez-Sanchez, A.; Klein, R.; Dudanova, I.; Hipp, M. S.; Hartl, F. U.; Baumeister, W. et al.; Fernandez-Busnadiego, R.: In situ architecture and cellular interactions of PolyQ inclusions. Cell 171 (1), S. 179 - 187 (2017)
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del Toro, D.; Ruff, T.; Cederfjäll, E.; Villalb, A.; Seyit-Bremer, G.; Borrell, V.; Klein, R.: Regulation of cerebral cortex folding by controlling neuronal migration via FLRT adhesion molecules. Cell 169 (4), S. 621 - 635 (2017)
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Douglass, A. M.; Kucukdereli, H.; Ponserre, M.; Markovic, M.; Gruendemann, J.; Strobel, C.; Alcala Morales, P. L.; Conzelmann, K.-K.; Luethi, A.; Klein, R.: Central amygdala circuits modulate food consumption through a positive-valence mechanism. Nature Neuroscience 20 (10), S. 1384 - 1394 (2017)
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Hosp, F.; Gutiérrez-Ángel, S.; Schaefer, M. H.; Cox, J.; Meissner, F.; Hipp, M. S.; Hartl, F. U.; Klein, R.; Dudanova, I.; Mann, M.: Spatiotemporal proteomic profiling of Huntington’s disease inclusions reveals widespread loss of protein function. Cell Reports 21 (8), S. 2291 - 2303 (2017)
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Hunt, S.; Sun, Y.; Kucukdereli, H.; Klein, R.; Sah, P.: Intrinsic circuits in the lateral central amygdala. eNeuro 4 (1), e0367-16.2017 (2017)
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Itzhak, D. N.; Davies, C.; Tyanova, S.; Mishra, A.; Williamson, J.; Antrobus, R.; Cox, J.; Weekes, M. P.; Borner, G. H. H.: A mass spectrometry-based approach for mapping protein subcellular localization reveals the spatial proteome of mouse primary neurons. Cell Reports 20 (11), S. 2706 - 2718 (2017)
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Kirik, D.; Cederfjall, E.; Halliday, G.; Petersen, A.: Gene therapy for Parkinson's disease: Disease modification by GDNF family of ligands. Neurobiology of Disease 97, S. 179 - 188 (2017)
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Tai-Nagara, I.; Yoshikawa, Y.; Numata, N.; Ando, T.; Okabe, K.; Sugiura, Y.; Ieda, M.; Takakura, N.; Nakagawa, O.; Zhou, B. et al.; Okabayashi, K.; Suematsu, M.; Kitagawa, Y.; Bastmeyer, M.; Sato, K.; Klein, R.; Navankasattusas, S.; Li, D. Y.; Yamagishi, S.; Kubota, Y.: Placental labyrinth formation in mice requires endothelial FLRT2/UNC5B signaling. Development 144 (13), S. 2392 - 2401 (2017)
2016
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Gaitanos, T. N.; Körner, J.; Klein, R.: Tiam-Rac signaling mediates trans-endocytosis of ephrin receptor EphB2 and is important for cell repulsion. The Journal of Cell Biology 214 (6), S. 735 - 752 (2016)
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Gong, J.; Körner, R.; Gaitanos, L.; Klein, R.: Exosomes mediate cell contact-independent ephrin-Eph signaling during axon guidance. The Journal of Cell Biology 214 (1), S. 35 - 44 (2016)
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Jackson, V. A.; Mehmood, S.; Chavent, M.; Roversi, P.; Carrasquero, M.; del Toro, D.; Seyit-Bremer, G.; Ranaivoson, F. M.; Comoletti, D.; Sansom, M. S. P. et al.; Robinson, C. V.; Klein, R.; Seiradake, E.: Super-complexes of adhesion GPCRs and neural guidance receptors. Nature Communications 7, 11184 (2016)
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Kania, A.; Klein, R.: Mechanisms of ephrin-Eph signalling in development, physiology and disease. Nature Reviews Molecular Cell Biology 17 (4), S. 240 - 256 (2016)
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Peuckert, C.; Aresh, B.; Holenya, P.; Adams, D.; Sreedharan, S.; Porthin, A.; Andersson, L.; Pettersson, H.; Wolfl, S.; Klein, R. et al.; Oxburgh, L.; Kullander, K.: Multimodal Eph/Ephrin signaling controls several phases of urogenital development. Kidney International 90 (2), S. 373 - 388 (2016)
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Seiradake, E.; Jones, E. Y.; Klein, R.: Structural perspectives on axon guidance. Annual Review of Cell and Developmental Biology 32, S. 577 - 608 (2016)
2015
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Fleming, M. S.; Vysochan, A.; Paixao, S.; Niu, J.; Klein, R.; Savitt, J. M.; Luo, W.: Cis and trans RET signaling control the survival and central projection growth of rapidly adapting mechanoreceptors. eLife 4, e06828 (2015)
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Howell, O. W.; Schulz-Trieglaff, E. K.; Carassiti, D.; Gentleman, S. M.; Nicholas, R.; Roncaroli, F.; Reynolds, R.: Extensive grey matter pathology in the cerebellum in multiple sclerosis is linked to inflammation in the subarachnoid space. Neuropathology and Applied Neurobiology 41 (6), S. 798 - 813 (2015)
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Jackson, V. A.; del Toro, D.; Carrasquero, M.; Roversi, P.; Harlos, K.; Klein, R.; Seiradake, E.: Structural basis of latrophilin-FLRT interaction. Structure 23 (4), S. 774 - 781 (2015)
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Lutz, J.; Dittmann, K.; Bösl, M. R.; Winkler, T. H.; Wienands, J.; Engels, N.: Reactivation of IgG-switched memory B cells by BCR-intrinsic signal amplification promotes IgG antibody production. Nature Communications 6, 8575 (2015)
2014
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Gatto, G.; Morales, D.; Kania, A.; Klein, R.: EphA4 receptor shedding regulates spinal motor axon guidance. Current Biology 24 (20), S. 2355 - 2365 (2014)
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Herberich, E.; Hassler, C.; Hothorn, T.: Multiple curve comparisons with an application to the formation of the dorsal funiculus of mutant mice. INTERNATIONAL JOURNAL OF BIOSTATISTICS 10 (2), S. 289 - 302 (2014)
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Klein, P.; Müller-Rischart, A. K.; Motori, E.; Schönbauer, C.; Schnorrer, F.; Winklhofer, K. F.; Klein, R.: Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants. The EMBO Journal 33 (4), S. 341 - 355 (2014)
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Klein, R.; Kania, A.: Ephrin signalling in the developing nervous system. Current Opinion in Neurobiology 27, S. 16 - 24 (2014)
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Leyva-Diaz, E.; del Toro, D.; Jose Menal, M.; Cambray, S.; Susin, R.; Tessier-Lavigne, M.; Klein, R.; Egea, J.; Lopez-Bendito, G.: FLRT3 is a Robo1-interacting protein that determines Netrin-1 attraction in developing axons. Current Biology 24 (5), S. 494 - 508 (2014)
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Mishra, A.; Traut, M. H.; Becker, L.; Klopstock, T.; Stein, V.; Klein, R.: Genetic evidence for the adhesion protein IgSF9/Dasm1 to regulate inhibitory synapse development independent of its intracellular domain. The Journal of Neuroscience 34 (12), S. 4187 - 4199 (2014)
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Schaupp, A.; Sabet, O.; Dudanova, I.; Ponserre, M.; Bastiaens, P.; Klein, R.: The composition of EphB2 clusters determines the strength in the cellular repulsion response. The Journal of Cell Biology 204 (3), S. 409 - 422 (2014)
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Schoenberger, M.; Damijonaitis, A.; Zhang, Z.; Nagel, D.; Trauner, D.: Development of a new photochromic ion channel blocker via azologization of fomocaine. ACS Chemical Neuroscience 5 (7), S. 514 - 518 (2014)
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Seiradake, E.; Del Toro Ruiz, D.; Nagel, D.; Cop, F.; Härtl, R.; Ruff, T.; Seyit-Bremer, G.; Harlos, K.; Border, E. C.; Acker-Palmer, A. et al.; Jones, E. Y.; Klein, R.: FLRT structure: Balancing repulsion and cell adhesion in cortical and vascular development. Neuron 84 (2), S. 370 - 385 (2014)
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