Max Planck Institute for Biological Intelligence

Publications of the department "Molecules - Signaling - Development"

Journal Article (173)

2026

Journal Article

Blumenstock, S.; Arakelyan, D.; del Grosso, N.; Schneider, S.; Shao, Y.; Gjoni, E.; Klein, R.; Dudanova, I.; Komiyama, T.: Optogenetic restoration of neuron subtype-specific cortical activity ameliorates motor deficits in Huntington’s Disease mice. bioRxiv: the preprint server for biology (2026)

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Bright, A. R.; Kotlyarenko, Y.; Neuhaus, F.; Rodrigues, D.; Feng, C.; Peters, C.; Vitali, I.; Dönmez, E.; Myoga, M.; Dvoretskova, E. et al.; Mayer, C.: NFIB influences progenitor competence in maturation of GABAergic neurons in mice. bioRxiv: the preprint server for biology (2026)

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da Silva Padilha, M.; Koyuncu, S.; Chabanis, E.; Ryazanov, S.; Leonov, A.; Vilchez, D.; Klein, R.; Giese, A.; Griesinger, C.; Dudanova, I.: Anle138b ameliorates pathological phenotypes in mouse and cellular models of Huntington's disease. bioRxiv: the preprint server for biology (2026)

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2025

Journal Article

Bright, A. R.; Kotlyarenko, Y.; Neuhaus, F.; Rodrigues, D.; Feng, C.; Peters, C.; Vitali, I.; Dönmez, E.; Myoga, M.; Dvoretskova, E. et al.; Mayer, C.: Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice. Nature Neuroscience 28 (8), pp. 1663 - 1675 (2025)

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Chun, S. H.; Yoon, D. E.; Diaz Almeida, D. S.; Todorov, M. I.; Straub, T.; Ruff, T.; Shao, W.; Yang, J.; Seyit-Bremer, G.; Shen, Y.-R. et al.; Ertürk, A.; del Toro, D.; Shi, S.; Klein, R.: Cortex folding by combined progenitor expansion and adhesion-controlled neuronal migration. Nature Communications 16, 8048 (2025)

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Fermani, F.; Chang, S.; Mastrodicasa, Y.; Peters, C.; Gaitanos, L.; Alcala Morales, P. L.; Ramakrishnan, C.; Deisseroth, K.; Klein, R.: Food and water intake are regulated by distinct central amygdala circuits revealed using intersectional genetics. Nature Communications 16, 3072 (2025)

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Journal Article

Murcia-Belmonte, V.; Chauvin, G.; Coca, Y.; Escalante, A.; Klein, R.; Herrera, E.: EphA4 mediates ephrinB1-dependent adhesion in retinal ganglion cells. The Journal of Neuroscience 45 (4), e0043242024 (2025)

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Shen, C.-J.; Chen, H.-C.; Lin, C.-L.; Thakur, A.; Onuku, R.; Chen, I.-C.; Li, H.-Y.; Chang, K.-Y.; Chuang, J.-Y.; Yang, W.-B. et al.; Lin, H.-Y.; Shen, Y.-R.; Liou, J.-P.; Chang, W.-C.; Hsu, T.-I.: Contribution of prostaglandin E2-induced neuronal excitation to drug resistance in glioblastoma countered by a novel blood–brain barrier crossing celecoxib derivative. Advanced Science 12 (38), e06336 (2025)

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Journal Article

Sitron, C. S.; Trinkaus, V. A.; Galesic, A.; Garhammer, M.; Yuste-Checa, P.; Dransfeld, U.; Feigenbutz, D.; Zhang, J.; Ivashko, L.; Dudanova, I. et al.; Harper, J. W.; Hartl, F. U.: α-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation. Molecular Cell 85 (18), pp. 3505 - 3523 (2025)

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2024

Journal Article

Ding, W.; Weltzien, H.; Peters, C.; Klein, R.: Nausea-induced suppression of feeding is mediated by central amygdala Dlk1-expressing neurons. Cell Reports 43 (4), 113990 (2024)

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Journal Article

Lim, H.; Zhang, Y.; Peters, C.; Straub, T.; Mayer, J. L.; Klein, R.: Genetically- and spatially-defined basolateral amygdala neurons control food consumption and social interaction. Nature Communications 15, 6868 (2024)

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Journal Article

Shen, Y.-R.; Zaballa, S.; Bech, X.; Sancho-Balsells, A.; Rodriguez-Navarro, I.; Cifuentes-Diaz, C.; Seyit-Bremer, G.; Chun, S. H.; Straub, T.; Abante, J. et al.; Merino-Valverde, I.; Richart, L.; Gupta, V.; Li, H.-Y.; Ballasch, I.; Alcazar, N.; Alberch, J.; Canals, J. M.; Abad, M.; Serrano, M.; Klein, R.; Giralt, A.; del Toro, D.: Expansion of the neocortex and protection from neurodegeneration by in vivo transient reprogramming. Cell Stem Cell 31 (12), pp. 1741 - 1759 (2024)

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2023

Journal Article

Peters, C.; He, S.; Fermani, F.; Lim, H.; Mayer, C.; Klein, R.: Transcriptomics reveals amygdala neuron regulation by fasting and ghrelin thereby promoting feeding. Science Advances 9 (21), eadf6521 (2023)

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publisher-version

Journal Article

Saha, I.; Yuste-Checa, P.; da Silva Padilha, M.; Guo, Q.; Korner, R.; Holthusen, H.; Trinkaus, V. A.; Dudanova, I.; Fernandez-Busnadiego, R.; Baumeister, W. et al.; Sanders, D. W.; Gautam, S.; Diamond, M. I.; Hartl, F. U.; Hipp, M. S.: The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system. Nature Communications 14, 560 (2023)

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Journal Article

Voelkl, K.; Gutiérrez-Ángel, S.; Keeling, S.; Koyuncu, S.; da Silva Padilha, M.; Feigenbutz, D.; Arzberger, T.; Vilchez, D.; Klein, R.; Dudanova, I.: Neuroprotective effects of hepatoma-derived growth factor in models of Huntington's disease. Life science alliance 6 (11), e202302018 (2023)

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2022

Journal Article

Chang, S.; Fermani, F.; Lao, C.-L.; Huang, L.; Jakovcevski, M.; Di Giaimo, R.; Gagliardi, M.; Menegaz, D.; Hennrich, A. A.; Ziller, M. et al.; Eder, M.; Klein, R.; Cai, N.; Deussing, J. M.: Tripartite extended amygdala-basal ganglia CRH circuit drives locomotor activation and avoidance behavior. Science Advances 8 (46), eabo1023 (2022)

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Journal Article

Ponserre, M.; Fermani, F.; Gaitanos, L.; Klein, R.: Encoding of environmental cues in central amygdala neurons during foraging. The Journal of Neuroscience 42 (18), pp. 3783 - 3796 (2022)

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publisher-version

Journal Article

Riera Tur, I.; Schäfer, T.; Hornburg, D.; Mishra, A.; da Silva Padilha, M.; Fernández-Mosquera, L.; Feigenbutz, D.; Auer, P.; Mann, M.; Baumeister, W. et al.; Klein, R.; Meissner, F.; Raimundo, N.; Fernandez-Busnadiego, R.; Dudanova, I.: Amyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicity. Life science alliance 5 (3), e202101185 (2022)

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publisher-version

Journal Article

Voelkl, K.; Schulz-Trieglaff, K.; Klein, R.; Dudanova, I.: Distinct histological alterations of cortical interneuron types in mouse models of Huntington’s disease. Frontiers in Neuroscience 16, 1022251 (2022)

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2021

Journal Article

Blumenstock, S.; Schulz-Trieglaff, E. K.; Voelkl, K.; Bolender, A.-L.; Lapios, P.; Lindner, J.; Hipp, M. S.; Hartl, F. U.; Klein, R.; Dudanova, I.: Fluc-EGFP reporter mice reveal differential alterations of neuronal proteostasis in aging and disease. The EMBO Journal 40 (19), e107260 (2021)

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Journal Article

Fleitas, C.; Marfull-Oromi, P.; Chauhan, D.; del Toro, D.; Peguera, B.; Zammou, B.; Rocandio, D.; Klein, R.; Espinet, C.; Egea, J.: FLRT2 and FLRT3 cooperate in maintaining the tangential migratory streams of cortical interneurons during development. The Journal of Neuroscience 41 (35), pp. 7350 - 7362 (2021)

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Journal Article

Haimson, B.; Meir, O.; Sudakevitz-Merzbach, R.; Elberg, G.; Friedrich, S.; Lovell V, P.; Paixao, S.; Klein, R.; Mello V, C.; Klar, A.: Natural loss of function of ephrin-B3 shapes spinal flight circuitry in birds. Science Advances 7 (24), eabg5968 (2021)

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Journal Article

Robinson, R. A.; Griffiths, S. C.; van de Haar, L. L.; Malinauskas, T.; van Battum, E. Y.; Zelina, P.; Schwab, R. A.; Karia, D.; Malinauskaite, L.; Brignani, S. et al.; van den Munkhof, M. H.; Dudukcu, O.; De Ruiter, A. A.; Van den Heuvel, D. M. A.; Bishop, B.; Elegheert, J.; Aricescu, A. R.; Pasterkamp, R. J.; Siebold, C.: Simultaneous binding of guidance cues NET1 and RGM blocks extracellular NEO1 signaling. Cell 184 (8), pp. 2103 - 2120.e31 (2021)

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Journal Article

Ruff, T.; Peters, C.; Matsumoto, A.; Ihle, S. J.; Alcala Morales, P. L.; Gaitanos, L.; Yonehara, K.; del Toro, D.; Klein, R.: FLRT3 marks direction-selective retinal ganglion cells that project to the medial terminal nucleus. Frontiers in Molecular Neuroscience 14, 790466 (2021)

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publisher-version

Journal Article

Trinkaus, V. A.; Riera Tur, I.; Martinez-Sanchez, A.; Bauerlein, F. J. B.; Guo, Q.; Arzberger, T.; Baumeister, W.; Dudanova, I.; Hipp, M. S.; Hartl, F. U. et al.; Fernandez-Busnadiego, R.: In situ architecture of neuronal α-Synuclein inclusions. Nature Communications 12, 2110 (2021)

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Journal Article

Yuste-Checa, P.; Trinkaus, V. A.; Riera Tur, I.; Imamoglu, R.; Schaller, T. F.; Wang, H.; Dudanova, I.; Hipp, M. S.; Bracher, A.; Hartl, F. U.: The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model. Nature Communications 12, 4863 (2021)

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2020

Journal Article

Blumenstock, S.; Dudanova, I.: Cortical and striatal circuits in Huntington's disease. Frontiers in Neuroscience 14, 82 (2020)

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publisher-version

Journal Article

del Toro, D.; Carrasquero-Ordaz, M. A.; Chu, A.; Ruff, T.; Shahin, M.; Jackson, V. A.; Chavent, M.; Berbeira-Santana, M.; Seyit-Bremer, G.; Brignani, S. et al.; Kaufmann, R.; Lowe, E.; Klein, R.; Seiradake, E.: Structural basis of Teneurin-Latrophilin interaction in repulsive guidance of migrating neurons. Cell 180 (2), pp. 323 - 339.e19 (2020)

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publisher-version

supplementary-material

Journal Article

Escalante, A.; Klein, R.: Spinal inhibitory Ptf1a-derived neurons prevent self-generated itch. Cell Reports 33 (8), 108422 (2020)

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Journal Article

Peters, C.; Bascunan, D.; Burgos, C. F.; Bobadilla, C.; Gonzalez-Sanmiguel, J.; Boopathi, S.; Riffo, N.; Fernandez-Perez, E. J.; Elena Tarnok, M.; Felipe Aguilar, L. et al.; Gonzalez, W.; Aguayo, L. G.: Characterization of a new molecule capable of inhibiting several steps of the amyloid cascade in Alzheimer's disease. Neurobiology of Disease 141, 104938 (2020)

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publisher-version

Journal Article

Ponserre, M.; Peters, C.; Fermani, F.; Conzelmann, K.-K.; Klein, R.: The insula cortex contacts distinct output streams of the central amygdala. The Journal of Neuroscience 40 (46), pp. 8870 - 8882 (2020)

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publisher-version

2019

Journal Article

Burgold, J.; Schulz-Trieglaff, E. K.; Voelkl, K.; Gutierrez-Angel, S.; Bader, J. M.; Hosp, F.; Mann, M.; Arzberger, T.; Klein, R.; Liebscher, S. et al.; Dudanova, I.: Cortical circuit alterations precede motor impairments in Huntington's disease mice. Scientific Reports 9, 6634 (2019)

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publisher-version

supplementary-material

Journal Article

Cramer, K.; Bolender, A.-L.; Stockmar, I.; Jungmann, R.; Kasper, R.; Shin, J. Y.: Visualization of bacterial protein complexes labeled with fluorescent proteins and nanobody binders for STED microscopy. International Journal of Molecular Sciences 20 (14), 3376 (2019)

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publisher-version

supplementary-material

Journal Article

Gong, J.; Gaitanos, T. N.; Luu, O.; Huang, Y.; Gaitanos, L.; Lindner, J.; Winklbauer, R.; Klein, R.: Gulp1 controls Eph/ephrin trogocytosis and is important for cell rearrangements during development. The Journal of Cell Biology 218 (10), pp. 3455 - 3471 (2019)

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publisher-version

supplementary-material

Journal Article

Paixao, S.; Loschek, L. F.; Gaitanos, L.; Alcala Morales, P. L.; Goulding, M.; Klein, R.: Identification of spinal neurons contributing to the dorsal column projection mediating fine touch and corrective motor movements. Neuron 104 (4), pp. 749 - 764.e6 (2019)

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Journal Article

Stuerner, T.; Tatarnikova, A.; Mueller, J.; Schaffran, B.; Cuntz, H.; Zhang, Y.; Nemethova, M.; Bogdan, S.; Small, V.; Tavosanis, G.: Transient localization of the Arp2/3 complex initiates neuronal dendrite branching in vivo. Development 146 (7), dev171397 (2019)

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2018

Journal Article

Klein, R.: Building a better brain: Making new connections. Cell 175 (3), pp. 633 - 634 (2018)

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2017

Journal Article

Bäuerlein, F. J. B.; Saha, I.; Mishra, A.; Kalemanov, M.; Martinez-Sanchez, A.; Klein, R.; Dudanova, I.; Hipp, M. S.; Hartl, F. U.; Baumeister, W. et al.; Fernandez-Busnadiego, R.: In situ architecture and cellular interactions of PolyQ inclusions. Cell 171 (1), pp. 179 - 187 (2017)

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Journal Article

del Toro, D.; Ruff, T.; Cederfjäll, E.; Villalb, A.; Seyit-Bremer, G.; Borrell, V.; Klein, R.: Regulation of cerebral cortex folding by controlling neuronal migration via FLRT adhesion molecules. Cell 169 (4), pp. 621 - 635 (2017)

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Journal Article

Douglass, A. M.; Kucukdereli, H.; Ponserre, M.; Markovic, M.; Gruendemann, J.; Strobel, C.; Alcala Morales, P. L.; Conzelmann, K.-K.; Luethi, A.; Klein, R.: Central amygdala circuits modulate food consumption through a positive-valence mechanism. Nature Neuroscience 20 (10), pp. 1384 - 1394 (2017)

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Journal Article

Hosp, F.; Gutiérrez-Ángel, S.; Schaefer, M. H.; Cox, J.; Meissner, F.; Hipp, M. S.; Hartl, F. U.; Klein, R.; Dudanova, I.; Mann, M.: Spatiotemporal proteomic profiling of Huntington’s disease inclusions reveals widespread loss of protein function. Cell Reports 21 (8), pp. 2291 - 2303 (2017)

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publisher-version

Journal Article

Hunt, S.; Sun, Y.; Kucukdereli, H.; Klein, R.; Sah, P.: Intrinsic circuits in the lateral central amygdala. eNeuro 4 (1), 0367-16.2017 (2017)

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publisher-version

Journal Article

Itzhak, D. N.; Davies, C.; Tyanova, S.; Mishra, A.; Williamson, J.; Antrobus, R.; Cox, J.; Weekes, M. P.; Borner, G. H. H.: A mass spectrometry-based approach for mapping protein subcellular localization reveals the spatial proteome of mouse primary neurons. Cell Reports 20 (11), pp. 2706 - 2718 (2017)

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publisher-version

Journal Article

Kirik, D.; Cederfjall, E.; Halliday, G.; Petersen, A.: Gene therapy for Parkinson's disease: Disease modification by GDNF family of ligands. Neurobiology of Disease 97, pp. 179 - 188 (2017)

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Journal Article

Tai-Nagara, I.; Yoshikawa, Y.; Numata, N.; Ando, T.; Okabe, K.; Sugiura, Y.; Ieda, M.; Takakura, N.; Nakagawa, O.; Zhou, B. et al.; Okabayashi, K.; Suematsu, M.; Kitagawa, Y.; Bastmeyer, M.; Sato, K.; Klein, R.; Navankasattusas, S.; Li, D. Y.; Yamagishi, S.; Kubota, Y.: Placental labyrinth formation in mice requires endothelial FLRT2/UNC5B signaling. Development 144 (13), pp. 2392 - 2401 (2017)

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2016

Journal Article

Gaitanos, T. N.; Körner, J.; Klein, R.: Tiam-Rac signaling mediates trans-endocytosis of ephrin receptor EphB2 and is important for cell repulsion. The Journal of Cell Biology 214 (6), pp. 735 - 752 (2016)

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Journal Article

Gong, J.; Körner, R.; Gaitanos, L.; Klein, R.: Exosomes mediate cell contact-independent ephrin-Eph signaling during axon guidance. The Journal of Cell Biology 214 (1), pp. 35 - 44 (2016)

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Journal Article

Jackson, V. A.; Mehmood, S.; Chavent, M.; Roversi, P.; Carrasquero, M.; del Toro, D.; Seyit-Bremer, G.; Ranaivoson, F. M.; Comoletti, D.; Sansom, M. S. P. et al.; Robinson, C. V.; Klein, R.; Seiradake, E.: Super-complexes of adhesion GPCRs and neural guidance receptors. Nature Communications 7, 11184 (2016)

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Journal Article

Kania, A.; Klein, R.: Mechanisms of ephrin-Eph signalling in development, physiology and disease. Nature Reviews Molecular Cell Biology 17 (4), pp. 240 - 256 (2016)

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Journal Article

Peuckert, C.; Aresh, B.; Holenya, P.; Adams, D.; Sreedharan, S.; Porthin, A.; Andersson, L.; Pettersson, H.; Wolfl, S.; Klein, R. et al.; Oxburgh, L.; Kullander, K.: Multimodal Eph/Ephrin signaling controls several phases of urogenital development. Kidney International 90 (2), pp. 373 - 388 (2016)

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