Pepe Alcami

Behavioural Neurobiology
+49 8157 932-387

Main Focus

My research aims at understanding how cells communicate with each other in the brain, how this communication underlies computation and coding in neural networks and how it ultimately determines behavior. I am currently investigating these questions in the song-related brain circuits in songbirds at the Max Planck for Ornithology (Seewiesen) in the laboratory of Prof. Manfred Gahr and at the LMU in Munich (Martinsried) in the laboratory of Prof. Benedikt Grothe.
If you would like to learn more about ongoing projects and join, please don’t hesitate to contact me! Internships for motivated bachelor and master students are available!! Currently Maximilian Franck is doing his master thesis on synaptic plasticity in canaries.

1. Electrical transmission in the vertebrate nervous system

Electrical and chemical synapses co-exist in most brain regions. Electrical synapses have a powerful and unique impact on network computation that is largely overlooked. I have previously studied their contribution to passive properties of interneurons in the cerebellum and the connectivity of interneuron networks connected by electrical synapses (Alcami and Marty, 2013). I also showed that electrical synapses decrease the excitability of neurons but comparatively enhance firing in response to coincident and sequential excitatory inputs (Alcami, 2018).

I am now studying the impact of electrical synapses on the computational abilities of coupled networks in songbirds and rodents. Ongoing projects aim at investigating:

• the interactions between electrical synapses and chemical synapses
• the interactions between electrical synapses and intrinsic properties of neurons
• the plasticity of electrical transmission and its impact on network computation and on behavior.

2. Neurobiological correlate of behavioral plasticity in songbirds

Songbirds learn their beautiful songs from their parents, so-called tutors. They sing owing to dedicated specific neural circuits involved in song learning and production (the so-called 'song system'). I am investigating the neurobiological basis of song production and learning in canaries and zebra finches. Songbirds are a great model to link synapses, cells, circuits and behavior.

3. Social modulation of singing

Singing is a social behavior. However, it has often been studied out of its social context. I am studying how songbirds interact during singing and how social interactions influence their singing behavior with the help of telemetry in freely-behaving birds.

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