Publikationen von Rüdiger Klein

Zeitschriftenartikel

Riera Tur, I.; Schäfer, T.; Hornburg, D.; Mishra, A.; da Silva Padilha, M.; Fernández-Mosquera, L.; Feigenbutz, D.; Auer, P.; Mann, M.; Baumeister, W. et al.; Klein, R.; Meissner, F.; Raimundo, N.; Fernandez-Busnadiego, R.; Dudanova, I.: Amyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicity. Life science alliance 5 (3), e202101185 (2022)

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Zeitschriftenartikel

Voelkl, K.; Schulz-Trieglaff, K.; Klein, R.; Dudanova, I.: Distinct histological alterations of cortical interneuron types in mouse models of Huntington’s disease. Frontiers in Neuroscience 16, 1022251 (2022)

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2021

Zeitschriftenartikel

Blumenstock, S.; Schulz-Trieglaff, E. K.; Voelkl, K.; Bolender, A.-L.; Lapios, P.; Lindner, J.; Hipp, M. S.; Hartl, F. U.; Klein, R.; Dudanova, I.: Fluc-EGFP reporter mice reveal differential alterations of neuronal proteostasis in aging and disease. The EMBO Journal 40 (19), e107260 (2021)

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Zeitschriftenartikel

Fleitas, C.; Marfull-Oromi, P.; Chauhan, D.; del Toro, D.; Peguera, B.; Zammou, B.; Rocandio, D.; Klein, R.; Espinet, C.; Egea, J.: FLRT2 and FLRT3 cooperate in maintaining the tangential migratory streams of cortical interneurons during development. The Journal of Neuroscience 41 (35), S. 7350 - 7362 (2021)

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Zeitschriftenartikel

Haimson, B.; Meir, O.; Sudakevitz-Merzbach, R.; Elberg, G.; Friedrich, S.; Lovell V, P.; Paixao, S.; Klein, R.; Mello V, C.; Klar, A.: Natural loss of function of ephrin-B3 shapes spinal flight circuitry in birds. Science Advances 7 (24), eabg5968 (2021)

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Zeitschriftenartikel

Klein, R.; Pasterkamp, R. J.: Recent advances in inter-cellular interactions during neural circuit assembly. Current Opinion in Neurobiology 69, S. 25 - 32 (2021)

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Zeitschriftenartikel

Ruff, T.; Peters, C.; Matsumoto, A.; Ihle, S. J.; Morales, P. A.; Gaitanos, L.; Yonehara, K.; del Toro, D.; Klein, R.: FLRT3 marks direction-selective retinal ganglion cells that project to the medial terminal nucleus. Frontiers in Molecular Neuroscience 14, 790466 (2021)

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2020

Zeitschriftenartikel

del Toro, D.; Carrasquero-Ordaz, M. A.; Chu, A.; Ruff, T.; Shahin, M.; Jackson, V. A.; Chavent, M.; Berbeira-Santana, M.; Seyit-Bremer, G.; Brignani, S. et al.; Kaufmann, R.; Lowe, E.; Klein, R.; Seiradake, E.: Structural basis of Teneurin-Latrophilin interaction in repulsive guidance of migrating neurons. Cell 180 (2), S. 323 - 339.e19 (2020)

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supplementary-material

Zeitschriftenartikel

Escalante, A.; Klein, R.: Spinal inhibitory Ptf1a-derived neurons prevent self-generated itch. Cell Reports 33 (8), 108422 (2020)

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ZIP

Zeitschriftenartikel

Ponserre, M.; Peters, C.; Fermani, F.; Conzelmann, K.-K.; Klein, R.: The insula cortex contacts distinct output streams of the central amygdala. The Journal of Neuroscience 40 (46), S. 8870 - 8882 (2020)

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2019

Zeitschriftenartikel

Burgold, J.; Schulz-Trieglaff, E. K.; Voelkl, K.; Gutierrez-Angel, S.; Bader, J. M.; Hosp, F.; Mann, M.; Arzberger, T.; Klein, R.; Liebscher, S. et al.; Dudanova, I.: Cortical circuit alterations precede motor impairments in Huntington's disease mice. Scientific Reports 9, 6634 (2019)

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supplementary-material

Zeitschriftenartikel

Gong, J.; Gaitanos, T. N.; Luu, O.; Huang, Y.; Gaitanos, L.; Lindner, J.; Winklbauer, R.; Klein, R.: Gulp1 controls Eph/ephrin trogocytosis and is important for cell rearrangements during development. The Journal of Cell Biology 218 (10), S. 3455 - 3471 (2019)

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supplementary-material

Zeitschriftenartikel

Paixao, S.; Loschek, L.; Gaitanos, L.; Morales, P. A.; Goulding, M.; Klein, R.: Identification of spinal neurons contributing to the dorsal column projection mediating fine touch and corrective motor movements. Neuron 104 (4), S. 749 - 764.e6 (2019)

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Abstr

2018

Zeitschriftenartikel

Klein, R.: Building a better brain: Making new connections. Cell 175 (3), S. 633 - 634 (2018)

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2017

Zeitschriftenartikel

Bäuerlein, F. J. B.; Saha, I.; Mishra, A.; Kalemanov, M.; Martinez-Sanchez, A.; Klein, R.; Dudanova, I.; Hipp, M. S.; Hartl, F. U.; Baumeister, W. et al.; Fernandez-Busnadiego, R.: In situ architecture and cellular interactions of PolyQ inclusions. Cell 171 (1), S. 179 - 187 (2017)

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Zeitschriftenartikel

del Toro, D.; Ruff, T.; Cederfjäll, E.; Villalb, A.; Seyit-Bremer, G.; Borrell, V.; Klein, R.: Regulation of cerebral cortex folding by controlling neuronal migration via FLRT adhesion molecules. Cell 169 (4), S. 621 - 635 (2017)

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Zeitschriftenartikel

Douglass, A. M.; Kucukdereli, H.; Ponserre, M.; Markovic, M.; Gruendemann, J.; Strobel, C.; Alcala Morales, P. L.; Conzelmann, K.-K.; Luethi, A.; Klein, R.: Central amygdala circuits modulate food consumption through a positive-valence mechanism. Nature Neuroscience 20 (10), S. 1384 - 1394 (2017)

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Zeitschriftenartikel

Hosp, F.; Gutiérrez-Ángel, S.; Schaefer, M. H.; Cox, J.; Meissner, F.; Hipp, M. S.; Hartl, F. U.; Klein, R.; Dudanova, I.; Mann, M.: Spatiotemporal proteomic profiling of Huntington’s disease inclusions reveals widespread loss of protein function. Cell Reports 21 (8), S. 2291 - 2303 (2017)

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Zeitschriftenartikel

Hunt, S.; Sun, Y.; Kucukdereli, H.; Klein, R.; Sah, P.: Intrinsic circuits in the lateral central amygdala. eNeuro 4 (1), e0367-16.2017 (2017)

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Zeitschriftenartikel

Tai-Nagara, I.; Yoshikawa, Y.; Numata, N.; Ando, T.; Okabe, K.; Sugiura, Y.; Ieda, M.; Takakura, N.; Nakagawa, O.; Zhou, B. et al.; Okabayashi, K.; Suematsu, M.; Kitagawa, Y.; Bastmeyer, M.; Sato, K.; Klein, R.; Navankasattusas, S.; Li, D. Y.; Yamagishi, S.; Kubota, Y.: Placental labyrinth formation in mice requires endothelial FLRT2/UNC5B signaling. Development 144 (13), S. 2392 - 2401 (2017)

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2016

Zeitschriftenartikel

Gaitanos, T. N.; Körner, J.; Klein, R.: Tiam-Rac signaling mediates trans-endocytosis of ephrin receptor EphB2 and is important for cell repulsion. The Journal of Cell Biology 214 (6), S. 735 - 752 (2016)

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Zeitschriftenartikel

Gong, J.; Körner, R.; Gaitanos, L.; Klein, R.: Exosomes mediate cell contact-independent ephrin-Eph signaling during axon guidance. The Journal of Cell Biology 214 (1), S. 35 - 44 (2016)

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Zeitschriftenartikel

Jackson, V. A.; Mehmood, S.; Chavent, M.; Roversi, P.; Carrasquero, M.; del Toro, D.; Seyit-Bremer, G.; Ranaivoson, F. M.; Comoletti, D.; Sansom, M. S. P. et al.; Robinson, C. V.; Klein, R.; Seiradake, E.: Super-complexes of adhesion GPCRs and neural guidance receptors. Nature Communications 7, 11184 (2016)

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Zeitschriftenartikel

Kania, A.; Klein, R.: Mechanisms of ephrin-Eph signalling in development, physiology and disease. Nature Reviews Molecular Cell Biology 17 (4), S. 240 - 256 (2016)

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Zeitschriftenartikel

Peuckert, C.; Aresh, B.; Holenya, P.; Adams, D.; Sreedharan, S.; Porthin, A.; Andersson, L.; Pettersson, H.; Wolfl, S.; Klein, R. et al.; Oxburgh, L.; Kullander, K.: Multimodal Eph/Ephrin signaling controls several phases of urogenital development. Kidney International 90 (2), S. 373 - 388 (2016)

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Zeitschriftenartikel

Seiradake, E.; Jones, E. Y.; Klein, R.: Structural perspectives on axon guidance. Annual Review of Cell and Developmental Biology 32, S. 577 - 608 (2016)

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2015

Zeitschriftenartikel

Fleming, M. S.; Vysochan, A.; Paixao, S.; Niu, J.; Klein, R.; Savitt, J. M.; Luo, W.: Cis and trans RET signaling control the survival and central projection growth of rapidly adapting mechanoreceptors. eLife 4, e06828 (2015)

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Zeitschriftenartikel

Jackson, V. A.; del Toro, D.; Carrasquero, M.; Roversi, P.; Harlos, K.; Klein, R.; Seiradake, E.: Structural basis of latrophilin-FLRT interaction. Structure 23 (4), S. 774 - 781 (2015)

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2014

Zeitschriftenartikel

Gatto, G.; Morales, D.; Kania, A.; Klein, R.: EphA4 receptor shedding regulates spinal motor axon guidance. Current Biology 24 (20), S. 2355 - 2365 (2014)

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Zeitschriftenartikel

Klein, P.; Müller-Rischart, A. K.; Motori, E.; Schönbauer, C.; Schnorrer, F.; Winklhofer, K. F.; Klein, R.: Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants. The EMBO Journal 33 (4), S. 341 - 355 (2014)

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Zeitschriftenartikel

Klein, R.; Kania, A.: Ephrin signalling in the developing nervous system. Current Opinion in Neurobiology 27, S. 16 - 24 (2014)

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Zeitschriftenartikel

Leyva-Diaz, E.; del Toro, D.; Jose Menal, M.; Cambray, S.; Susin, R.; Tessier-Lavigne, M.; Klein, R.; Egea, J.; Lopez-Bendito, G.: FLRT3 is a Robo1-interacting protein that determines Netrin-1 attraction in developing axons. Current Biology 24 (5), S. 494 - 508 (2014)

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Zeitschriftenartikel

Mishra, A.; Traut, M. H.; Becker, L.; Klopstock, T.; Stein, V.; Klein, R.: Genetic evidence for the adhesion protein IgSF9/Dasm1 to regulate inhibitory synapse development independent of its intracellular domain. The Journal of Neuroscience 34 (12), S. 4187 - 4199 (2014)

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Zeitschriftenartikel

Schaupp, A.; Sabet, O.; Dudanova, I.; Ponserre, M.; Bastiaens, P.; Klein, R.: The composition of EphB2 clusters determines the strength in the cellular repulsion response. The Journal of Cell Biology 204 (3), S. 409 - 422 (2014)

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Zeitschriftenartikel

Seiradake, E.; Del Toro Ruiz, D.; Nagel, D.; Cop, F.; Härtl, R.; Ruff, T.; Seyit-Bremer, G.; Harlos, K.; Border, E. C.; Acker-Palmer, A. et al.; Jones, E. Y.; Klein, R.: FLRT structure: Balancing repulsion and cell adhesion in cortical and vascular development. Neuron 84 (2), S. 370 - 385 (2014)

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Zeitschriftenartikel

Serradj, N.; Paixao, S.; Sobocki, T.; Feinberg, M.; Klein, R.; Kullander, K.; Martin, J. H.: EphA4-mediated ipsilateral corticospinal tract misprojections are necessary for bilateral voluntary movements but not bilateral stereotypic locomotion. The Journal of Neuroscience 34 (15), S. 5211 - 5221 (2014)

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2013

Zeitschriftenartikel

Dimidschstein, J.; Passante, L.; Dufour, A.; van den Ameele, J.; Tiberi, L.; Hrechdakian, T.; Adams, R.; Klein, R.; Lie, D. C.; Jossin, Y. et al.; Vanderhaeghen, P.: Ephrin-B1 controls the columnar distribution of cortical pyramidal neurons by restricting their tangential migration. Neuron 79 (6), S. 1123 - 1135 (2013)

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Zeitschriftenartikel

Dudanova, I.; Klein, R.: Integration of guidance cues: Parallel signaling and crosstalk. Trends in Neurosciences 36 (5), S. 295 - 304 (2013)

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Zeitschriftenartikel

Gatto, G.; Dudanova, I.; Suetterlin, P.; Davies, A. M.; Drescher, U.; Bixby, J. L.; Klein, R.: Protein tyrosine phosphatase receptor type O inhibits trigeminal axon growth and rranching by repressing TrkB and ret signaling. The Journal of Neuroscience 33 (12), S. 5399 - 5410 (2013)

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Zeitschriftenartikel

Paixao, S.; Balijepalli, A.; Serradj, N.; Niu, J.; Luo, W.; Martin, J. H.; Klein, R.: EphrinB3/EphA4-mediated guidance of ascending and descending spinal tracts. Neuron 80 (6), S. 1407 - 1420 (2013)

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Zeitschriftenartikel

Seiradake, E.; Schaupp, A.; Del Toro Ruiz, D.; Kaufmann, R.; Mitakidis, N.; Harlos, K.; Aricescu, A. R.; Klein, R.; Jones, E. Y.: Structurally encoded intraclass differences in EphA clusters drive distinct cell responses. Nature Structural and Molecular Biology 20 (8), S. 958 - 964 (2013)

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2012

Zeitschriftenartikel

Dudanova, I.; Kao, T.-J.; Herrmann, J. E.; Zheng, B.; Kania, A.; Klein, R.: Genetic evidence for a contribution of EphA: EphrinA reverse signaling to motor axon guidance. The Journal of Neuroscience 32 (15), S. 5209 - 5215 (2012)

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Zeitschriftenartikel

Fontana, X.; Hristova, M.; Da Costa, C.; Patodia, S.; Thei, L.; Makwana, M.; Spencer-Dene, B.; Latouche, M.; Mirsky, R.; Jessen, K. R. et al.; Klein, R.; Raivich, G.; Behrens, A.: C-Jun in Schwann cells promotes axonal regeneration and motoneuron survival via paracrine signaling. The Journal of Cell Biology 198 (1), S. 127 - 141 (2012)

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Zeitschriftenartikel

Klein, R.: Eph/ephrin signalling during development. Development 139 (22), S. 4105 - 4109 (2012)

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2011

Zeitschriftenartikel

Aron, L.; Klein, R.: Repairing the parkinsonian brain with neurotrophic factors. Trends in Neurosciences 34 (2), S. 88 - 100 (2011)

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Zeitschriftenartikel

Dudanova, I.; Klein, R.: The axon's balancing act: Cis- and trans-interactions between Ephs and Ephrins. Neuron 71 (1), S. 1 - 3 (2011)

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Zeitschriftenartikel

Peng, C.; Aron, L.; Klein, R.; Li, M.; Wurst, W.; Prakash, N.; Le, W.: Pitx3 is a critical mediator of GDNF-induced BDNF expression in nigrostriatal dopaminergic neurons. The Journal of Neuroscience 31 (36), S. 12802 - 12815 (2011)

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Zeitschriftenartikel

Wang, L.; Klein, R.; Zheng, B. H.; Marquardt, T.: Anatomical coupling of sensory and motor nerve trajectory via axon tracking. Neuron 71 (2), S. 263 - 277 (2011)

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Zeitschriftenartikel

Yamagishi, S.; Hampel, F.; Hata, K.; Del Toro Ruiz, D.; Schwark, M.; Kvachnina, E.; Bastmeyer, M.; Yamashita, T.; Tarabykin, V.; Klein, R. et al.; Egea, J.: FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons. The EMBO Journal 30 (14), S. 2920 - 2933 (2011)

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