Publications of H. Wekerle

Journal Article (100)

2009
Journal Article
Bauer, M.; Brakebusch, C.; Coisne, C.; Sixt, M.; Wekerle, H.; Engelhardt, B.; Fässler, R.: beta(1) integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity. Proceedings of the National Academy of Sciences of the United States of America 106 (6), pp. 1920 - 1925 (2009)
Journal Article
Derfuss, T.; Parikh, K.; Velhin, S.; Braun, M.; Mathey, E.; Krumbholz, M.; Kümpfel, T.; Moldenhauer, A.; Rader, C.; Sonderegger, P. et al.; Pöllmann, W.; Tiefenthaller, C.; Bauer, J.; Lassmann, H.; Wekerle, H.; Karagogeos, D.; Hohlfeld, R.; Linington, C.; Meinl, E.: Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals. Proceedings of the National Academy of Sciences of the United States of America 106 (20), pp. 8302 - 8307 (2009)
Journal Article
Junker, A.; Krumbholz, M.; Eisele, S.; Mohan, H.; Augstein, F.; Bittner, R.; Lassmann, H.; Wekerle, H.; Hohlfeld, R.; Meinl, E.: MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47. Brain 132, pp. 3342 - 3352 (2009)
Journal Article
Krishnamoorthy, G.; Saxena, A.; Mars, L. T.; Domingues, H. S.; Ben-Nun, A.; Lassmann, H.; Dornmair, K.; Mentele, R.; Kurschus, F. C.; Liblau, R. S. et al.; Wekerle, H.: Myelin-specific T cells also recognize neuronal autoantigen in a transgenic mouse model of multiple sclerosis. Nature Medicine 15 (6), pp. 626 - 632 (2009)
Journal Article
Krishnamoorthy, G.; Wekerle, H.: EAE: An immunologist's magic eye. European Journal of Immunology 39 (8), pp. 2031 - 2035 (2009)
Journal Article
Pöllinger, B.; Krishnamoorthy, G.; Berer, K.; Lassmann, H.; Bösl, M. R.; Dunn, R.; Domingues, H. S.; Holz, A.; Kurschus, F. C.; Wekerle, H.: Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells. Journal of Experimental Medicine 206 (6), pp. 1303 - 1316 (2009)
2008
Journal Article
Hohlfeld, R.; Wekerle, H.: Reflections on the "intrathymic pathogenesis" of myasthenia gravis. Journal of Neuroimmunology 201-202, pp. 21 - 27 (2008)
Journal Article
Obermeier, B.; Malotka, J.; Kellermann, J.; Kümpfel, T.; Wekerle, H.; Lottspeich, F.; Mentele, R.; Hohlfeld, R.; Dornmair, K.: Matching of oligoclonal immunoglobulin transcriptomes and proteomes of cerebrospinal fluid in multiple sclerosis. Nature Medicine 14 (6), pp. 688 - 693 (2008)
2007
Journal Article
Grundtner, R.; Dornmair, K.; Dahm, R.; Flügel, A.; Kawakami, N.; Zeitelhofer, M.; Schoderboeck, L.; Nosov, M.; Selzer, E.; Willheim, M. et al.; Kiebler, M.; Wekerle, H.; Lassmann, H.; Bradl, M.: Transition from enhanced T cell infiltration to inflammation in the myelin-degenerative central nervous system. Neurobiology of Disease 28 (3), pp. 261 - 275 (2007)
Journal Article
Junker, A.; Ivanidze, J.; Malotka, J.; Eiglmeier, I.; Lassmann, H.; Wekerle, H.; Meinl, E.; Hohlfeld, R.; Dornmair, K.: Multiple sclerosis: T-cell receptor expression in distinct brain regions. Brain 130, pp. 2789 - 2799 (2007)
Journal Article
Krishnamoorthy, G.; Holz, A.; Wekerle, H.: Experimental models of spontaneous in the central nervous system. Journal of Molecular Medicine-JMM 85 (11), pp. 1161 - 1173 (2007)
Journal Article
Odoardi, F.; Kawakami, N.; Klinkert, W. E. F.; Wekerle, H.; Flügel, A.: Blood-borne soluble protein antigen intensifies T cell activation in autoimmune CNS lesions and exacerbates clinical disease. Proceedings of the National Academy of Sciences of the United States of America 104 (47), pp. 18625 - 18630 (2007)
Journal Article
Odoardi, F.; Kawakami, N.; Li, Z. X.; Cordiglieri, C.; Streyl, K.; Nosov, M.; Klinkert, W. E. F.; Ellwart, J. W.; Bauer, J.; Lassmann, H. et al.; Wekerle, H.; Flügel, A.: Instant effect of soluble antigen on effector T cells in peripheral immune organs during immunotherapy of autoimmune encephalomyelitis. Proceedings of the National Academy of Sciences of the United States of America 104 (3), pp. 920 - 925 (2007)
Journal Article
Wekerle, H.: L'énigme de l'entrée des lymphocytes T auto-immuns dans les tissus nerveux centraux et de leur attaque contre les structures de myéline. Comptes Rendus Biologies 330, pp. 1 - 12 (2007)
2006
Journal Article
Hohlfeld, R.; Kerschensteiner, M.; Stadelmann, C.; Lassmann, H.; Wekerle, H.: The neuroprotective effect of inflammation: Implications for the therapy of multiple sclerosis. Neurological Sciences 27, pp. S1 - S7 (2006)
Journal Article
Krishnamoorthy, G.; Lassmann, H.; Wekerle, H.; Holz, A.: Spontaneous opticospinal encephalomyelitis in a double-transgenic mouse model of autoimmune T cell B cell cooperation. Journal of Clinical Investigation 116 (9), pp. 2385 - 2392 (2006)
Journal Article
Seitz, S.; Schneider, C. K.; Malotka, J.; Nong, X.; Engel, A. G.; Wekerle, H.; Hohlfeld, R.; Dornmair, K.: Reconstitution of paired T cell receptor alpha- and beta-chains from microdissected single cells of human inflammatory tissues. Proceedings of the National Academy of Sciences of the United States of America 103 (32), pp. 12057 - 12062 (2006)
Journal Article
Wekerle, H.; Kurschus, F. C.: Animal models of multiple sclerosis. Drug Discovery Today: Disease Models 3 (4), pp. 359 - 367 (2006)
Journal Article
Wekerle, H.; Linington, C.: Organ specific autoantigens and the autoreactive T cell repertoire: The case of myelin oligodendrocyte glycoprotein. European Journal of Immunology 36 (3), pp. 512 - 515 (2006)
2005
Journal Article
Bradl, M.; Bauer, J.; Flügel, A.; Wekerle, H.; Lassmann, H.: Complementary contribution of CD4 and CD8 T lymphocytes to T-cell infiltration of the intact and the degenerative spinal cord. American Journal of Pathology 166 (5), pp. 1441 - 1450 (2005)
Journal Article
Farina, C.; Weber, M. S.; Meinl, E.; Wekerle, H.; Hohlfeld, R.: Glatiramer acetate in multiple sclerosis: update on potential mechanisms of action. Lancet Neurology 4 (9), pp. 567 - 575 (2005)
Journal Article
Hohlfeld, R.; Wekerle, H.: Drug insight: Using monoclonal antibodies to treat multiple sclerosis. Nature Clinical Practice Neurology 1, pp. 34 - 44 (2005)
Journal Article
Kawakami, N.; Nägerl, U. V.; Odoardi, F.; Bonhoeffer, T.; Wekerle, H.; Flügel, A.: Live imaging of effector cell trafficking and autoantigen recognition within the unfolding autoimmune encephalomyelitis lesion. Journal of Experimental Medicine 201 (11), pp. 1805 - 1814 (2005)
Journal Article
Kawakami, N.; Odoardi, F.; Ziemssen, T.; Bradl, M.; Ritter, T.; Neuhaus, O.; Lassmann, H.; Wekerle, H.; Flügel, A.: Autoimmune CD4(+) T cell memory: Lifelong persistence of encephalitogenic T cell clones in healthy immune repertoires. Journal of Immunology 175 (1), pp. 69 - 81 (2005)
Journal Article
Krumbholz, M.; Theil, D.; Derfuss, T.; Rosenwald, A.; Schrader, F.; Monoranu, C. M.; Kalled, S. L.; Hess, D. M.; Serafini, B.; Aloisi, F. et al.; Wekerle, H.; Hohlfeld, R.; Meinl, E.: BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma. Journal of Experimental Medicine 201 (2), pp. 195 - 200 (2005)
Journal Article
Wekerle, H.: Immune pathogenesis of multiple sclerosis. Neurological Sciences 26 (1), pp. S1 - S2 (2005)
Journal Article
Wekerle, H.: Planting and pruning in the brain: MHC antigens involved in synaptic plasticity? Proceedings of the National Academy of Sciences of the United States of America 102 (1), pp. 3 - 4 (2005)
2004
Journal Article
Aboul-Enein, F.; Bauer, J.; Klein, M.; Schubart, A.; Flügel, A.; Ritter, T.; Kawakami, N.; Siedler, F.; Linington, C.; Wekerle, H. et al.; Lassmann, H.; Bradl, M.: Selective and antigen-dependent effects of myelin degeneration on central nervous system inflammation. Journal of Neuropathology and Experimental Neurology 63 (12), pp. 1284 - 1296 (2004)
Journal Article
Hohlfeld, R.; Wekerle, H.: Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: From pipe dreams to (therapeutic) pipelines. Proceedings of the National Academy of Sciences of the United States of America 101 (Suppl. Suppl. 2), pp. 14599 - 14606 (2004)
Journal Article
Kawakami, N.; Lassmann, S.; Li, Z. X.; Odoardi, F.; Ritter, T.; Ziemssen, T.; Klinkert, W. E. F.; Ellwart, J. W.; Bradl, M.; Krivacic, K. et al.; Lassmann, H.; Ransohoff, R. M.; Volk, H. D.; Wekerle, H.; Linington, C.; Flügel, A.: The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of autoimmune encephalomyelitis. Journal of Experimental Medicine 199 (2), pp. 185 - 197 (2004)
Journal Article
Kawakami, N.; Nägerl, U. V.; Wekerle, H.; Flügel, A.: Live-imaging of encephalitogenic T lymphocytes in the living target tissue. Journal of Neuroimmunology 154 (1-2 Sp. Iss. Sp. Iss. SI), p. 224 - 224 (2004)
Journal Article
Skulina, C.; Schmidt, S.; Dornmair, K.; Babbe, H.; Roers, A.; Rajewsky, K.; Wekerle, H.; Hohlfeld, R.; Goebels, N.: Multiple sclerosis: Brain-infiltrating CD8(+) T cells persist as clonal expansions in the cerebrospinal fluid and blood. Proceedings of the National Academy of Sciences of the United States of America 101 (8), pp. 2428 - 2433 (2004)
2003
Journal Article
Dornmair, K.; Goebels, N.; Weltzien, H. U.; Wekerle, H.; Hohlfeld, R.: T-cell-mediated autoimmunity - Novel techniques to characterize autoreactive T-cell receptors. American Journal of Pathology 163 (4), pp. 1215 - 1226 (2003)
Journal Article
Hofbauer, M.; Wiesener, S.; Babbe, H.; Roers, A.; Wekerle, H.; Dornmair, K.; Goebels, N.: Clonal tracking of autoaggressive T cells in polymyositis by combining laser microdissection, single-cell PCR, and CDR3-spectratype analysis. Proceedings of the National Academy of Sciences U S A 100 (7), pp. 4090 - 4095 (2003)
Journal Article
Kerschensteiner, M.; Stadelmann, C.; Dechant, G.; Wekerle, H.; Hohlfeld, R.: Neurotrophic cross-talk between the nervous and immune systems: Implications for neurological diseases. Annals of Neurology 53 (3), pp. 292 - 304 (2003)
Journal Article
Wekerle, H.; Hohlfeld, R.: Molecular mimicry in multiple sclerosis. New England Journal of Medicine 349 (2), pp. 185 - 186 (2003)
2002
Journal Article
Bauer, J.; Bradl, M.; Klein, M.; Leisser, M.; Deckwerth, T. L.; Wekerle, H.; Lassmann, H.: Endoplasmic reticulum stress in PLP-overexpressing transgenic rats: Gray matter oligodendrocytes are more vulnerable than white matter oligodendrocytes. Journal of Neuropathology and Experimental Neurology 61 (1), pp. 12 - 22 (2002)
Journal Article
Neumann, H.; Schweigreiter, R.; Yamashita, T.; Rosenkranz, K.; Wekerle, H.; Barde, Y. A.: Tumor necrosis factor inhibits neurite outgrowth and branching of hippocampal neurons by a Rho-dependent mechanism. The Journal of Neuroscience 22 (3), pp. 854 - 862 (2002)
Journal Article
Wekerle, H.: Immune protection of the brain - Efficient and delicate. The Journal of Infectious Diseases 186 (Suppl. 2), pp. S140 - S144 (2002)
Journal Article
Wekerle, H.: Medicine - Tackling multiple sclerosis. Nature 420 (6911), pp. 39 - 40 (2002)
Journal Article
Wiendl, H.; Malotka, J.; Holzwarth, B.; Weltzien, H. U.; Wekerle, H.; Hohlfeld, R.; Dornmair, K.: An autoreactive gamma delta TCR derived from a polymyositis lesion. Journal of Immunology 169 (1), pp. 515 - 521 (2002)
2001
Journal Article
Flugel, A.; Matsumuro, K.; Neumann, H.; Klinkert, W. E. F.; Birnbacher, R.; Lassmann, H.; Otten, U.; Wekerle, H.: Anti-inflammatory activity of nerve growth factor in experimental autoimmune encephalomyelitis: Inhibition of monocyte transendothelial migration. European Journal of Immunology 31 (1), pp. 11 - 22 (2001)
Journal Article
Medana, I.; Martinic, M. A.; Wekerle, H.; Neumann, H.: Transection of major histocompatibility complex class I-induced neurites by cytotoxic T lymphocytes. American Journal of Pathology 159 (3), pp. 809 - 815 (2001)
2000
Journal Article
Hohlfeld, R.; Kerschensteiner, M.; Stadelmann, C.; Lassmann, H.; Wekerle, H.: The neuroprotective effect of inflammation: Implications for the therapy of multiple sclerosis. Journal of Neuroimmunology 107 (2), pp. 161 - 166 (2000)
1999
Journal Article
Bradl, M.; Bauer, J.; Inomata, T.; Zielasek, J.; Nave, K. A.; Toyka, K.; Lassmann, H.; Wekerle, H.: Transgenic Lewis rats overexpressing the proteolipid protein gene: myelin degeneration and its effect on T cell-mediated experimental autoimmune encephalomyelitis. Acta Neuropathologica 97 (6), pp. 595 - 606 (1999)
Journal Article
Kerschensteiner, M.; Gallmeier, E.; Behrens, L.; Vargas-Leal, V.; Misgeld, T.; Klinkert, W. E. F.; Kolbeck, R.; Hoppe, E.; Oropeza-Wekerle, R. L.; Bartke, I. et al.; Stadelmann, C.; Lassmann, H.; Wekerle, H.; Hohlfeld, R.: Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: A neuroprotective role of inflammation? Journal of Experimental Medicine 189 (5), pp. 865 - 870 (1999)
1998
Journal Article
Bauer, J.; Bradl, M.; Hickey, W. F.; Forss-Petter, S.; Breitschopf, H.; Linington, C.; Wekerle, H.; Lassmann, H.: T-cell apoptosis in inflammatory brain lesions - Destruction of T cells does not depend on antigen recognition. American Journal of Pathology 153 (3), pp. 715 - 724 (1998)
Journal Article
Behrens, L.; Kerschensteiner, M.; Misgeld, T.; Goebels, N.; Wekerle, H.; Hohlfeld, R.: Human muscle cells express a functional costimulatory molecule distinct from B7,1 (CD80) and B7,2 (CD86) in vitro and in inflammatory lesions. The Journal of Immunology 161 (11), pp. 5943 - 5951 (1998)
Journal Article
Litzenburger, T.; Fässler, R.; Bauer, J.; Lassmann, H.; Linington, C.; Wekerle, H.; Iglesias, A.: B lymphocytes producing demyelinating autoantibodies: Development and function in gene-targeted transgenic mice. Journal of Experimental Medicine 188 (1), pp. 169 - 180 (1998)
Journal Article
Wekerle, H.: The viral triggering of autoimmune disease. Nature Medicine 4 (7), pp. 770 - 771 (1998)
Go to Editor View