Publikationen von R. Klein

Zeitschriftenartikel (186)

2011
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Aron, L.; Klein, R.: Repairing the parkinsonian brain with neurotrophic factors. Trends in Neurosciences 34 (2), S. 88 - 100 (2011)
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Dudanova, I.; Klein, R.: The axon's balancing act: Cis- and trans-interactions between Ephs and Ephrins. Neuron 71 (1), S. 1 - 3 (2011)
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Peng, C.; Aron, L.; Klein, R.; Li, M.; Wurst, W.; Prakash, N.; Le, W.: Pitx3 is a critical mediator of GDNF-induced BDNF expression in nigrostriatal dopaminergic neurons. The Journal of Neuroscience 31 (36), S. 12802 - 12815 (2011)
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Wang, L.; Klein, R.; Zheng, B. H.; Marquardt, T.: Anatomical coupling of sensory and motor nerve trajectory via axon tracking. Neuron 71 (2), S. 263 - 277 (2011)
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Yamagishi, S.; Hampel, F.; Hata, K.; del Toro Ruiz, D.; Schwark, M.; Kvachnina, E.; Bastmeyer, M.; Yamashita, T.; Tarabykin, V.; Klein, R. et al.; Egea, J.: FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons. The EMBO Journal 30 (14), S. 2920 - 2933 (2011)
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Zhai, J.; Zhou, W.; Li, J.; Hayworth, C. R.; Zhang, L.; Misawa, H.; Klein, R.; Scherer, S. S.; Balice-Gordon, R. J.; Kalb, R. G.: The in vivo contribution of motor neuron TrkB receptors to mutant SOD1 motor neuron disease. Human Molecular Genetics 20 (21), S. 4116 - 4131 (2011)
2010
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Aron, L.; Klein, P.; Pham, T. T.; Kramer, E. R.; Wurst, W.; Klein, R.: Pro-survival role for Parkinson's associated gene DJ-1 revealed in trophically impaired dopaminergic neurons. PLoS Biology 8 (4), e1000349 (2010)
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Bashaw, G. J.; Klein, R.: Signaling from axon guidance receptors. Cold Spring Harbor Perspectives in Biology 2 (5), a001941 (2010)
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Dudanova, I.; Gatto, G.; Klein, R.: GDNF acts as a chemoattractant to support ephrinA-induced repulsion of limb motor axons. Current Biology 20 (23), S. 2150 - 2156 (2010)
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Griciuc, A.; Aron, L.; Roux, M. J.; Klein, R.; Giangrande, A.; Ueffing, M.: Inactivation of VCP/ter94 suppresses retinal pathology caused by misfolded Rhodopsin in Drosophila. PLoS Genetics 6 (8), e1001075 (2010)
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Klein, R.: Cell sorting during regenerative tissue formation. Cell 143 (1), S. 32 - 34 (2010)
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Klein, R.: Topography in hippocampal mossy fiber plasticity. Neuron 65 (5), S. 580 - 582 (2010)
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Paixao, S.; Klein, R.: Neuron-astrocyte communication and synaptic plasticity. Current Opinion in Neurobiology 20 (4), S. 466 - 473 (2010)
2009
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Filosa, A.; Paixao, S.; Honsek, S. D.; Carmona, M. A.; Becker, L.; Feddersen, B.; Gaitanos, L.; Rudhard, Y.; Schoepfer, R.; Klopstock, T. et al.; Kullander, K.; Rose, C. R.; Pasquale, E. B.; Klein, R.: Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport. Nature Neuroscience 12 (10), S. 1285 - 1292 (2009)
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Klein, R.: Bidirectional modulation of synaptic functions by Eph/ephrin signaling. Nature Neuroscience 12 (1), S. 15 - 20 (2009)
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Strelau, J.; Strzelczyk, A.; Rusu, P.; Bendner, G.; Wiese, S.; Diella, F.; Altick, A. L.; von Bartheld, C. S.; Klein, R.; Sendtner, M. et al.; Unsicker, K.: Progressive postnatal motoneuron loss in mice lacking GDF-15. The Journal of Neuroscience 29 (43), S. 13640 - 13648 (2009)
2008
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Deininger, K.; Eder, M.; Kramer, E. R.; Zieglgänsberger, W.; Dodt, H. U.; Dornmair, K.; Colicelli, J.; Klein, R.: The Rab5 guanylate exchange factor Rin1 regulates endocytosis of the EphA4 receptor in mature excitatory neurons. Proceedings of the National Academy of Sciences of the United States of America 105 (34), S. 12539 - 12544 (2008)
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Egea, J.; Erlacher, C.; Montanez, E.; Burtscher, I.; Yamagishi, S.; Hess, M.; Hampel, F.; Sanchez, R.; Rodriguez-Manzaneque, M. T.; Bösl, M. R. et al.; Faessler, R.; Lickert, H.; Klein, R.: Genetic ablation of FLRT3 reveals a novel morphogenetic function for the anterior visceral endoderm in suppressing mesoderm differentiation. Genes and Development 22 (23), S. 3349 - 3362 (2008)
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Essmann, C. L.; Martinez, E.; Geiger, J. C.; Zimmer, M.; Traut, M. H.; Stein, V.; Klein, R.; Acker-Palmer, A.: Serine phosphorylation of ephrinB2 regulates trafficking of synaptic AMPA receptors. Nature Neuroscience 11 (9), S. 1035 - 1043 (2008)
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Hulshagen, L.; Krysko, O.; Bottelbergs, A.; Huyghe, S.; Klein, R.; Van Veldhoven, P. P.; De Deyn, P. P.; D'Hooge, R.; Hartmann, D.; Baes, M.: Absence of functional peroxisomes from mouse CNS causes dysmyelination and axon degeneration. The Journal of Neuroscience 28 (15), S. 4015 - 4027 (2008)
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Kappeler, L.; Filho, C. D. M.; Dupont, J.; Leneuve, P.; Cervera, P.; Perin, L.; Loudes, C.; Blaise, A.; Klein, R.; Epelbaum, J. et al.; Le Bouc, Y.; Holzenberger, M.: Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism. PLoS Biology 6 (10), e254, S. 2144 - 2153 (2008)
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Mishra, A.; Knerr, B.; Paixao, S.; Kramer, E. R.; Klein, R.: The protein dendrite arborization and synapse maturation 1 (Dasm-1) is dispensable for dendrite arborization. Molecular and Cellular Biology (Washington, DC) 28 (8), S. 2782 - 2791 (2008)
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Wilkinson, G. A.; Schittny, J. C.; Reinhardt, D. P.; Klein, R.: Role for ephrinB2 in postnatal lung alveolar development and elastic matrix integrity. Developmental Dynamics 237 (8), S. 2220 - 2234 (2008)
2007
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Bouzioukh, F.; Wilkinson, G. A.; Adelmann, G.; Frotscher, M.; Stein, V.; Klein, R.: Tyrosine phosphorylation sites in ephrinB2 are required for hippocampal long-term potentiation but not long-term depression. The Journal of Neuroscience 27 (42), S. 11279 - 11288 (2007)
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Cull-Candy, S.; Klein, R.: Signalling mechanisms. Current Opinion in Neurobiology 17 (3), S. 277 - 280 (2007)
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Egea, J.; Klein, R.: Bidirectional Eph-ephrin signaling during axon guidance. Trends in Cell Biology 17 (5), S. 230 - 238 (2007)
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Ke, Y. H.; Zhang, E. E.; Hagihara, K.; Wu, D. M.; Pang, Y. H.; Klein, R.; Curran, T.; Ranscht, B.; Feng, G. S.: Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethality. Molecular and Cellular Biology (Washington, DC) 27 (19), S. 6706 - 6717 (2007)
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Kowsky, S.; Poppelmeyer, C.; Kramer, E. R.; Falkenburger, B. H.; Kruse, A.; Klein, R.; Schulz, J. B.: RET signaling does not modulate MPTP toxicity but is required for regeneration of dopaminergic axon terminals. Proceedings of the National Academy of Sciences of the United States of America 104 (50), S. 20049 - 20054 (2007)
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Kramer, E. R.; Aron, L.; Ramakers, G. M. J.; Seitz, S.; Zhuang, X. X.; Beyer, K.; Smidt, M. P.; Klein, R.: Absence of ret signaling in mice causes progressive and late degeneration of the nigrostriatal system. PLoS Biology 5 (3), e39, S. 616 - 628 (2007)
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Krysko, O.; Hulshagen, L.; Janssen, A.; Schutz, G.; Klein, R.; De Bruycker, M.; Espeel, M.; Gressens, P.; Baes, M.: Neocortical and cerebellar developmental abnormalities in conditions of selective elimination of peroxisomes from brain or from liver. Journal of Neuroscience Research 85 (1), S. 58 - 72 (2007)
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Wegmeyer, H.; Egea, J.; Rabe, N.; Gezelius, H.; Filosa, A.; Enjin, A.; Varoqueaux, F.; Deininger, K.; Schnuetgen, F.; Brose, N. et al.; Klein, R.; Kullander, K.; Betz, A.: EphA4-dependent axon guidance is mediated by the RacGAP alpha2-chimaerin. Neuron 55 (5), S. 756 - 767 (2007)
2006
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Ambrosino, C.; Iwata, T.; Scafoglio, C.; Mallardo, M.; Klein, R.; Nebreda, A. R.: TEF-1 and C/EBPβ are major p38α MAPK-regulated transcription factors in proliferating cardiomyocytes. Biochemical Journal 396 (1), S. 163 - 172 (2006)
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Angrand, P. O.; Segura, I.; Volkel, P.; Ghidelli, S.; Terry, R.; Brajenovic, M.; Vintersten, K.; Klein, R.; Superti-Furga, G.; Drewes, G. et al.; Kuster, B.; Bouwmeester, T.; Acker-Palmer, A.: Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling. Molecular and Cellular Proteomics 5 (12), S. 2211 - 2227 (2006)
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Dufour, A.; Egea, J.; Kullander, K.; Klein, R.; Vanderhaeghen, P.: Genetic analysis of EphA-dependent signaling mechanisms controlling topographic mapping in vivo. Development 133 (22), S. 4415 - 4420 (2006)
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Ferby, I.; Reschke, M.; Kudlacek, O.; Knyazev, P.; Pante, G.; Amann, K.; Sommergruber, W.; Kraut, N.; Ullrich, A.; Faessler, R. et al.; Klein, R.: Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation. Nature Medicine 12 (5), S. 568 - 573 (2006)
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Kadison, S. R.; Mäkinen, T.; Klein, R.; Henkemeyer, M.; Kaprielian, Z.: EphB receptors and ephrin-B3 regulate axon guidance at the ventral midline of the embryonic mouse spinal cord. The Journal of Neuroscience 26 (35), S. 8909 - 8914 (2006)
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Kramer, E. R.; Knott, L.; Su, F. Y.; Dessaud, E.; Krull, C. E.; Helmbacher, F.; Klein, R.: Cooperation between GDNF/Ret and ephrinA/EphA4 signals for motor-axon pathway selection in the limb. Neuron 50 (1), S. 35 - 47 (2006)
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Lauterbach, J.; Klein, R.: Release of full-length EphB2 receptors from hippocampal neurons to cocultured glial cells. The Journal of Neuroscience 26 (45), S. 11575 - 11581 (2006)
2005
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Diehl, S.; Bruno, R.; Wilkinson, G. A.; Loose, D.; Wilting, J.; Schweigerer, L.; Klein, R.: Altered expression patterns of EphrinB2 and EphB2 in human umbilical vessels and congenital venous malformations. Pediatric Research 57 (4), S. 537 - 544 (2005)
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Egea, J.; Nissen, U. V.; Dufour, A.; Sahin, M.; Greer, P.; Kullander, K.; Mrsic-Flogel, T. D.; Greenberg, M. E.; Kiehn, O.; Vanderhaeghen, P. et al.; Klein, R.: Regulation of EphA4 kinase activity is required for a subset of axon guidance decisions suggesting a key role for receptor clustering in Eph function. Neuron 47 (4), S. 515 - 528 (2005)
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Klein, R.: Axon guidance: Opposing EPHects in the growth cone. Cell 121 (1), S. 4 - 6 (2005)
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Mäkinen, T.; Adams, R. H.; Bailey, J.; Lu, Q.; Ziemiecki, A.; Alitalo, K.; Klein, R.; Wilkinson, G. A.: PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature. Genes and Development 19 (3), S. 397 - 410 (2005)
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Pante, G.; Thompson, J.; Lamballe, F.; Iwata, T.; Ferby, I.; Barr, F. A.; Davies, A. M.; Maina, F.; Klein, R.: Mitogen-inducible gene 6 is an endogenous inhibitor of HGF/Met-induced cell migration and neurite growth. The Journal of Cell Biology 171 (2), S. 337 - 348 (2005)
2004
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Anton, E. S.; Ghashghaei, H. T.; Weber, J. L.; McCann, C.; Fischer, T. M.; Cheung, I. D.; Gassmann, M.; Messing, A.; Klein, R.; Schwab, M. H. et al.; Lloyd, K. C. K.; Lai, C.: Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain. Nature Neuroscience 7 (12), S. 1319 - 1328 (2004)
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Grunwald, I. C.; Korte, M.; Adelmann, G.; Plueck, A.; Kullander, K.; Adams, R. H.; Frotscher, M.; Bonhoeffer, T.; Klein, R.: Hippocampal plasticity requires postsynaptic ephrinBs. Nature Neuroscience 7 (1), S. 33 - 40 (2004)
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Klein, R.: Eph/ephrin signaling in morphogenesis, neural development and plasticity. Current Opinion in Cell Biology 16 (5), S. 580 - 589 (2004)
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Thuret, S.; Alavian, K.N.; Gassmann, M.; Lloyd, C.; Smits, S.M.; Smidt, M.P.; Klein, R.; Dyck, R.H.; Simon, H.: The neuregulin receptor, ErbB4, is not required for normal development and adult maintenance of the substantia nigra pars compacta. Journal of Neurochemistry 91 (6), S. 1302 - 1311 (2004)
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Yang, X. D.; Klein, R.; Tian, X. L.; Cheng, H. T.; Kopan, R.; Shen, J.: Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Developmental Biology 269 (1), S. 81 - 94 (2004)
2003
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Compagni, A.; Logan, M.; Klein, R.; Adams, R.H.: Control of skeletal patterning by ephrinB1-EphB interactions. Developmental Cell 5, S. 217 - 230 (2003)
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Haigh, J. J.; Morelli, P. I.; Gerhardt, H.; Haigh, K.; Tsien, J.; Damert, A.; Miquerol, L.; Muhlner, U.; Klein, R.; Ferrara, N. et al.; Wagner, E. F.; Betsholtz, C.; Nagy, A.: Cortical and retinal defects caused by dosage-dependent reductions in VEGF-A paracrine signaling. Developmental Biology 26 (2), S. 225 - 241 (2003)
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